ClinicalTrials.gov record
Comparing an Operation to Monitoring, With or Without Endocrine Therapy (COMET) Trial For Low Risk DCIS
ClinicalTrials.gov ID: NCT02926911
Public ClinicalTrials.gov record NCT02926911. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Comparing an Operation to Monitoring, With or Without Endocrine Therapy (COMET) Trial For Low Risk DCIS: A Phase III Prospective Randomized Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study looks at the risks and benefits of active monitoring (AM) compared to surgery in the setting of a pragmatic prospective randomized trial for low risk DCIS. Our overarching hypothesis is that management of low-risk Ductal Carcinoma in Situ (DCIS) using an AM approach does not yield inferior cancer or quality of life outcomes compared to surgery.
Study identification
- NCT ID
- NCT02926911
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 997 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years to 99 Years
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 22, 2017 (Actual)
- Primary completion
- Jun 27, 2024 (Actual)
- Completion
- Jul 2030 (Estimated)
- Last update posted
- May 12, 2026
2017 – 2030
United States locations
- U.S. sites
- 141
- U.S. states
- 40
- U.S. cities
- 120
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Providence Alaska Medical Center | Anchorage | Alaska | 99508 | — |
| Mayo Clinic | Phoenix | Arizona | 85054 | — |
| City of Hope | Duarte | California | 91010 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Sharp Memorial Hospital | San Diego | California | 92123 | — |
| Kaiser Permanente Medical Center | Vallejo | California | 94589 | — |
| Colorado Cancer Research Program | Denver | Colorado | 80222 | — |
| Saint Joseph Hospital- Cancer Centers of Colorado | Lafayette | Colorado | 80026 | — |
| Smilow Cancer Hospital at Yale-New Haven | New Haven | Connecticut | 06510 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Memorial Healthcare System | Hollywood | Florida | 33021 | — |
| Mayo Clinic Florida | Jacksonville | Florida | 32224 | — |
| University of Hawaii Cancer Center | Honolulu | Hawaii | 96813 | — |
| Kootenai Health | Post Falls | Idaho | 83854 | — |
| John H Stroger Jr Hospital of Cook County | Chicago | Illinois | 60612 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Advocate Illinois Masonic Medical Center | Chicago | Illinois | 60657 | — |
| NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | 60201 | — |
| Ingalls Memorial Hospital | Harvey | Illinois | 60426 | — |
| Illinois Cancer Care | Peoria | Illinois | 61615 | — |
| OSF Saint Anthony Medical Center | Rockford | Illinois | 61108 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Medical Oncology and Hematology Associates - Des Moines | Des Moines | Iowa | 50314 | — |
| University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | 52242 | — |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| St. Elizabeth Healthcare Edgewood | Edgewood | Kentucky | 41017 | — |
| University of Kentucky/Markey Cancer Center | Lexington | Kentucky | 40536 | — |
| Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | 70809 | — |
| Ochsner Medical Center Jefferson | New Orleans | Louisiana | 70121 | — |
| Eastern Maine Medical Center Cancer Care | Brewer | Maine | 04412 | — |
| Maine Center for Cancer Medicine-Scarborough | Scarborough | Maine | 04074 | — |
| New England Cancer Specialists | Scarborough | Maine | 04074 | — |
| Anne Arundel Medical Center | Annapolis | Maryland | 21401 | — |
| University of Maryland - Greenebaum Comprehensive Cancer Center | Baltimore | Maryland | 21201 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Saint Joseph Mercy Hospital | Ann Arbor | Michigan | 48197 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Cancer Research Consortium of West Michigan | Grand Rapids | Michigan | 49503 | — |
| Beaumont NCORP | Royal Oak | Michigan | 48073 | — |
| Masonic Cancer Center, University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Metro MN Community Oncology Research Consortium (MMCORC) | Saint Louis Park | Minnesota | 55416 | — |
| Washington University - Siteman Cancer Center | St Louis | Missouri | 63110 | — |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | — |
| Billings Clinic | Billings | Montana | 59101 | — |
| Bozeman Health | Bozeman | Montana | 59715 | — |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Kalispell Regional Medical Center | Kalispell | Montana | 59901 | — |
| Community Medical Center | Missoula | Montana | 59804 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| New Hampshire Oncology Hematology PA | Hooksett | New Hampshire | 03106 | — |
| Englewood Hospital and Medical Center | Englewood | New Jersey | 07631 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Atlantic Health System / Morristown Medical Center | Morristown | New Jersey | 07960 | — |
| Jersey Shore University Medical Center | Neptune City | New Jersey | 07753 | — |
| The Valley Hospital - Luckow Pavilion | Paramus | New Jersey | 07652 | — |
| New Mexico Cancer Care Alliance | Albuquerque | New Mexico | 87106 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| New York-Presbyterian Weill Cornell Medical Center | New York | New York | 10065 | — |
| Mount Sinai Hospital | New York | New York | 60608 | — |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | — |
| Montefiore-Einstein Center for Cancer Care at Montefiore Medical Park | The Bronx | New York | 10461 | — |
| UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | 27599 | — |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | — |
| Novant Health Presbyterian Medical Center | Charlotte | North Carolina | 28204 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Cape Fear Valley Health System | Fayetteville | North Carolina | 28304 | — |
| Southeastern Medical Oncology Center | Goldsboro | North Carolina | 27534 | — |
| Cone Health Cancer Center | Greensboro | North Carolina | 27403 | — |
| Novant Health Breast Surgery - Greensboro | Greensboro | North Carolina | 27403 | — |
| East Carolina University | Greenville | North Carolina | 27834 | — |
| Carolina East Medical Center | New Bern | North Carolina | 28561 | — |
| Rex Cancer Center | Raleigh | North Carolina | 27607 | — |
| Wake Forest Baptist Medical Center | Winston-Salem | North Carolina | 27157 | — |
| Strecker Cancer Center - Belpre | Belpre | Ohio | 45714 | — |
| Dayton Physicians-Miami Valley Hospital South | Centerville | Ohio | 45459 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43202 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Mount Carmel East Hospital | Columbus | Ohio | 43213 | — |
| Columbus Oncology & Hematology INC | Columbus | Ohio | 43214 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Grant Medical Center | Columbus | Ohio | 43215 | — |
| MidOhio Oncology Hematology, Mark H. Zangmeister Center | Columbus | Ohio | 43219 | — |
| Mount Carmel West Hospital | Columbus | Ohio | 43223 | — |
| Doctors Hospital | Columbus | Ohio | 43228 | — |
| Dayton Physicians-Miami Valley Hospital North | Dayton | Ohio | 45415 | — |
| Grady Hospital | Delaware | Ohio | 43015 | — |
| OhioHealth Grady - Delaware Health Center | Delaware | Ohio | 43015 | — |
| Armes Family Cancer Center | Findlay | Ohio | 45840 | — |
| Dayton Physicians-Atrium | Franklin | Ohio | 45005 | — |
| Wayne Hospital | Greenville | Ohio | 45331 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| OhioHealth Mansfield Hospital | Mansfield | Ohio | 44903 | — |
| Marietta Memorial Hospital | Marietta | Ohio | 45750 | — |
| OhioHealth Marion General Hospital | Marion | Ohio | 43302 | — |
| Licking Memorial Hospital | Newark | Ohio | 43055 | — |
| St. Ann's Hospital | Westerville | Ohio | 43081 | — |
| St. Elizabeth Youngstown Hospital | Youngstown | Ohio | 44501 | — |
| Genesis Health Care System | Zanesville | Ohio | 43701 | — |
| Cancer Centers of Southwest Oklahoma | Lawton | Oklahoma | 73505 | — |
| Saint Charles Health System | Bend | Oregon | 97701 | — |
| Magee-Womens Hospital of UPMC | Pittsburgh | Pennsylvania | 15213 | — |
| Guthrie Medical Group PC-Robert Packer Hospital | Sayre | Pennsylvania | 18840 | — |
| WellSpan Health York Cancer Center | York | Pennsylvania | 17403 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02906 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Georgetown Hospital System | Georgetown | South Carolina | 29440 | — |
| Greenville Memorial Hospital | Greenville | South Carolina | 29605 | — |
| Baptist Cancer Care | Memphis | Tennessee | 38120 | — |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | 75235 | — |
| Baylor University Medical Center | Dallas | Texas | 75246 | — |
| MD Anderson Cancer Center | Houston | Texas | 60586 | — |
| Doctors Hospital of Laredo | Laredo | Texas | 78045 | — |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | — |
| The University of Vermont Medical Center | Burlington | Vermont | 05401 | — |
| West Virginia University Medicine | Morgantown | Virginia | 26506 | — |
| Sentara Norfolk General Hospital | Norfolk | Virginia | 23507 | — |
| Virginia Commonwealth University Massey Cancer Center | Richmond | Virginia | 23298 | — |
| Overlake Hospital Medical Center | Bellevue | Washington | 98004 | — |
| ThedaCare Regional Cancer Center -Appleton | Appleton | Wisconsin | 54911 | — |
| Aurora Health Care, Aurora Cancer Care | Burlington | Wisconsin | 53105 | — |
| Aurora Health Center - Fond du Lac | Fond du Lac | Wisconsin | 54937 | — |
| Aurora Health Care, Germantown Health Center | Germantown | Wisconsin | 53022 | — |
| Aurora Health Care, Aurora Cancer Care | Grafton | Wisconsin | 53024 | — |
| Saint Vincent Hospital | Green Bay | Wisconsin | 54301 | — |
| BayCare Aurora LLC, Aurora Cancer Care | Green Bay | Wisconsin | 54311 | — |
| Aurora Health Care, Aurora Cancer Care | Kenosha | Wisconsin | 49408 | — |
| University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | 53792 | — |
| Aurora Bay Area Medical Group - Cancer Care Clinic | Marinette | Wisconsin | 54143 | — |
| Aurora Health Care, Aurora Cancer Care | Marinette | Wisconsin | 54143 | — |
| Aurora Health Care, Aurora Cancer Care | Milwaukee | Wisconsin | 53209 | — |
| Vince Lombardi Cancer Clinic of Aurora St. Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
| Froedtert and the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Aurora Health Care, Aurora Cancer Care | Milwaukee | Wisconsin | 53233 | — |
| Aurora Health Care, Aurora Cancer Care | Oshkosh | Wisconsin | 54904 | — |
| Aurora Health Care, Aurora Cancer Care | Racine | Wisconsin | 53406 | — |
| Aurora Health Care, Aurora Cancer Care | Sheboygan | Wisconsin | 53081 | — |
| Aurora Health Care, Aurora Cancer Care | Summit | Wisconsin | 53066 | — |
| Aurora Health Care, Aurora Cancer Care | Two Rivers | Wisconsin | 54241 | — |
| Aurora Health Care, Aurora Cancer Care | Wauwatosa | Wisconsin | 53226 | — |
| Aurora Health Care, Aurora Cancer Care | West Allis | Wisconsin | 53227 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02926911, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 12, 2026 · Synced Oct 16, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02926911 live on ClinicalTrials.gov.