A Study to Evaluate Efficacy and Safety of SAGE-547 in Participants With Severe Postpartum Depression (547-PPD-202B)
Public ClinicalTrials.gov record NCT02942004. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study Evaluating the Efficacy, Safety, and Pharmacokinetics of SAGE-547 Injection in the Treatment of Adult Female Subjects With Severe Postpartum Depression and Adult Female Subjects With Moderate Postpartum Depression
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study was to determine if SAGE-547 Injection infused intravenously at up to 90 micrograms per kilogram per hour (μg/kg/h) for 60 hours reduces depressive symptoms in participants with severe postpartum depression (PPD) compared to placebo injection as assessed by the change from baseline in Hamilton Rating Scale for Depression (HAM-D) total score.
Study identification
- NCT ID
- NCT02942004
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 138 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 45 Years
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 1, 2016 (Actual)
- Primary completion
- Sep 24, 2017 (Actual)
- Completion
- Oct 19, 2017 (Actual)
- Last update posted
- Oct 14, 2025
2016 – 2017
United States locations
- U.S. sites
- 32
- U.S. states
- 17
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Sage Investigational Site | Chandler | Arizona | 85226 | — |
| Sage Investigational Site | Rogers | Arkansas | 72758 | — |
| Sage Investigational Site | Lemon Grove | California | 91945 | — |
| Sage Investigational Site | Orange | California | 92868 | — |
| Sage Investigational Site | Ventura | California | 93003 | — |
| Sage Investigational Site | Gainesville | Florida | 32607 | — |
| Sage Investigational Site | Miami | Florida | 33147 | — |
| Sage Investigational Site | Miramar | Florida | 33027 | — |
| Sage Investigational Site | Orlando | Florida | 32807 | — |
| Sage Investigational Site | Pensacola | Florida | 32502 | — |
| Sage Investigational Site | Pinellas Park | Florida | 33782 | — |
| Sage Investigational Site | Atlanta | Georgia | 30331 | — |
| Sage Investigational Site | Hoffman Estates | Illinois | 60169 | — |
| Sage Investigational Site | Wichita | Kansas | 67226 | — |
| Sage Investigational Site | Edgewood | Kentucky | 41017 | — |
| Sage Investigational Site | Owensboro | Kentucky | 42303 | — |
| Sage Investigational Site | Boston | Massachusetts | 02114 | — |
| Sage Investigational Site | Boston | Massachusetts | 02115 | — |
| Sage Investigational Site | Flowood | Mississippi | 39232 | — |
| Sage Investigational Site | Marlton | New Jersey | 08053 | — |
| Sage Investigational Site | Glen Oaks | New York | 11004 | — |
| Sage Investigational Site | Chapel Hill | North Carolina | 27514 | — |
| Sage Investigational Site | Charlotte | North Carolina | 28211 | — |
| Sage Investigational Site | Raleigh | North Carolina | 27612 | — |
| Sage Investigational Site | Columbus | Ohio | 43210 | — |
| Sage Investigational Site | Dayton | Ohio | 45417 | — |
| Sage Investigational Site | Philadelphia | Pennsylvania | 19104 | — |
| Sage Investigational Site | Houston | Texas | 77030 | — |
| Sage Investigational Site | Houston | Texas | 77058 | — |
| Sage Investigational Site | Richardson | Texas | 75080 | — |
| Sage Investigational Site | San Antonio | Texas | 78229 | — |
| Sage Investigational Site | Orem | Utah | 84058 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02942004, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 14, 2025 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02942004 live on ClinicalTrials.gov.