A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-02)
Public ClinicalTrials.gov record NCT02943564. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
A Randomized, Double-blind, Placebo-controlled, Multicenter Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the efficacy, safety, and tolerability of two doses of rapastinel, 225 milligrams (mg) and 450 mg, compared to placebo adjunctive to antidepressant therapy (ADT) in patients with major depressive disorder (MDD) who have a partial response to ADT.
Study identification
- NCT ID
- NCT02943564
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 658 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 1, 2016 (Actual)
- Primary completion
- Dec 12, 2018 (Actual)
- Completion
- Dec 18, 2018 (Actual)
- Last update posted
- Dec 27, 2019
2016 – 2018
United States locations
- U.S. sites
- 66
- U.S. states
- 24
- U.S. cities
- 59
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| University of Arizona Department of Psychiatry | Tucson | Arizona | 85724 | — |
| Woodland International Research Group | Little Rock | Arkansas | 72211 | — |
| Woodland Research Northwest | Rogers | Arkansas | 72758 | — |
| California Pharmaceutical Research Institute, Inc | Anaheim | California | 92804 | — |
| ProScience Research Group | Culver City | California | 90230 | — |
| Behavioral Research Specialists, LLC | Glendale | California | 91206 | — |
| Synergy Clinical Research Center of Escondido | Lemon Grove | California | 91945 | — |
| Pacific Research Partners; LLC. | Oakland | California | 94607 | — |
| CITrials | Riverside | California | 92506 | — |
| Artemis Institute for Clinical Research | San Diego | California | 92103 | — |
| PCSD Feighner Research | San Diego | California | 92108 | — |
| Sarkis Clinical Trials | Gainesville | Florida | 32607 | — |
| Reliable Clinical Research | Hialeah | Florida | 33012 | — |
| Advanced Research Institute of Miami | Homestead | Florida | 33030 | — |
| Innovative Clinical Research, Inc | Lauderhill | Florida | 33319 | — |
| International Research Associates, LLC | Miami | Florida | 33183 | — |
| Sarkis Clinical Trials | Ocala | Florida | 34474 | — |
| Medical Research Group of Central Florida | Orange City | Florida | 32763 | — |
| Clinical Neuroscience Solutions, Inc | Orlando | Florida | 32801 | — |
| Millenia Psychiatry & Research, Inc | Orlando | Florida | 32839 | — |
| iResearch Atlanta, LLC | Decatur | Georgia | 30030 | — |
| IRIS Research | Smyrna | Georgia | 30080 | — |
| Great Lakes Clinical Trials | Chicago | Illinois | 60640 | — |
| Alexian Brothers Center for Psychiatric Research | Hoffman Estates | Illinois | 60169 | — |
| Capstone Clinical Research | Libertyville | Illinois | 60048 | — |
| Phoenix Medical Research | Prairie Village | Kansas | 66208 | — |
| Heartland Research Associates | Wichita | Kansas | 67207 | — |
| Lake Charles Clinical Trials | Lake Charles | Louisiana | 70629 | — |
| J Gary Booker, MD APMC | Shreveport | Louisiana | 71104 | — |
| Pharmasite Research, Inc | Baltimore | Maryland | 21208 | — |
| CBH Health | Rockville | Maryland | 20850 | — |
| Boston Clinical Trials | Boston | Massachusetts | 02131 | — |
| ActivMed Practices & Research, Inc. | Methuen | Massachusetts | 01844 | — |
| BTC of New Bedford | New Bedford | Massachusetts | 02740 | — |
| Coastal Research Associates | Weymouth | Massachusetts | 02190 | — |
| Precise Research Centers | Flowood | Mississippi | 39232 | — |
| Millennium Psychiatric Associates | Olivette | Missouri | 63132 | — |
| Center for Emotional Fitness | Cherry Hill | New Jersey | 08002 | — |
| Pharmaceutical Research Associates Inc | Marlton | New Jersey | 08053 | — |
| The Medical Research Network, LLC | New York | New York | 10128 | — |
| Richmond Behavioral Associates | Staten Island | New York | 10312 | — |
| Richard H. Weisler, MD, PA | Raleigh | North Carolina | 27609 | — |
| Patient Priority Clinical Site, LLC | Cincinnati | Ohio | 45215 | — |
| The Ohio State University Department of Psychiatry | Columbus | Ohio | 43210 | — |
| Charak Clinical Research Center | Garfield Heights | Ohio | 44125 | — |
| Lindner Center of Hope | Mason | Ohio | 45040 | — |
| Professional Psychiatric Services | Mason | Ohio | 45040 | — |
| Red River Medical Research Center, LLC | Oklahoma City | Oklahoma | 73112 | — |
| Sooner Clinical Research, Inc | Oklahoma City | Oklahoma | 73112 | — |
| Paradigm Research Professionals | Oklahoma City | Oklahoma | 73118 | — |
| Summit Research Network | Portland | Oregon | 97210 | — |
| Lehigh Center for Clinical Research | Allentown | Pennsylvania | 18104 | — |
| Suburban Research Associates | Media | Pennsylvania | 19063 | — |
| Carolina Clinical Trials, Inc. | Charleston | South Carolina | 29407 | — |
| Coastal Carolina Research Center, Inc. | Mt. Pleasant | South Carolina | 29464 | — |
| Community Clinical Research, Inc. | Austin | Texas | 78754 | — |
| BioBehavioral Research of Austin | Austin | Texas | 78759 | — |
| Relaro Medical Trials | Dallas | Texas | 75243 | — |
| El Campo Clinical Trials | El Campo | Texas | 77347 | — |
| Earle Research | Houston | Texas | 77058 | — |
| Red Oak Psychiatry Associates, PA | Houston | Texas | 77090 | — |
| Family Psychiatry of The Wood | The Woodlands | Texas | 77381 | — |
| PRA Health Sciences | Salt Lake City | Utah | 84106 | — |
| Pacific Institute of Medical Sciences | Bothell | Washington | 98011 | — |
| Eastside Therapeutic Resource | Everett | Washington | 98201 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02943564, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 27, 2019 · Synced Nov 7, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02943564 live on ClinicalTrials.gov.