A Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder (RAP-MD-03)
Public ClinicalTrials.gov record NCT02943577. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-controlled, Multicenter Study of Rapastinel as Adjunctive Therapy in Major Depressive Disorder
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the efficacy, safety, and tolerability of rapastinel 450 milligrams (mg) compared to placebo adjunctive to antidepressant therapy (ADT) in patients with major depressive disorder (MDD) who have a partial response to ADT.
Study identification
- NCT ID
- NCT02943577
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 429 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 2, 2016 (Actual)
- Primary completion
- Oct 26, 2018 (Actual)
- Completion
- Nov 21, 2018 (Actual)
- Last update posted
- Nov 13, 2019
2016 – 2018
United States locations
- U.S. sites
- 40
- U.S. states
- 23
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Harmonex Neuroscience Research | Dothan | Alabama | 36303 | — |
| NoesisPharma | Phoenix | Arizona | 85016 | — |
| Sun Valley Research Center | Imperial | California | 92251 | — |
| Irvine Center for Clinical Research, Inc | Irvine | California | 92614 | — |
| NRC Research Institute | Orange | California | 92868 | — |
| Asclepes Research Centers | Panorama City | California | 91402 | — |
| Artemis Institute for Clinical Research | San Marcos | California | 92078 | — |
| MCB Clinical Research Center | Colorado Springs | Colorado | 80910 | — |
| Gulfcoast Clinical Research Center | Fort Myers | Florida | 33912 | — |
| Research Centers of America | Hollywood | Florida | 33024 | — |
| Innova Clinical Trials Inc. | Miami | Florida | 33133 | — |
| Combined Research Orlando Phase I-IV | Orlando | Florida | 32807 | — |
| Olympian Clinical Research | Tampa | Florida | 33609 | — |
| The University of South Florida Board of Trustees, A public Body Corporate, for University of South Florida | Tampa | Florida | 33613 | — |
| Northwest Behavioral Research Center | Marietta | Georgia | 30060 | — |
| AMR - Baber Research, Inc. | Naperville | Illinois | 60563 | — |
| Psychiatric Associates | Overland Park | Kansas | 66211 | — |
| Louisiana Clinical Research | Shreveport | Louisiana | 71101 | — |
| Sheppard Pratt Health System | Baltimore | Maryland | 21204 | — |
| University of Massachusetts Medical School | Worcester | Massachusetts | 01655 | — |
| Psychiatric Care and Research Center | O'Fallon | Missouri | 63368 | — |
| St. Charles Psychiatric Associates - Midwest Research Group | Saint Charles | Missouri | 63304 | — |
| Alivation Research | Lincoln | Nebraska | 68526 | — |
| Healthy Perspectives - Innovative Mental Health Services. PLLC | Nashua | New Hampshire | 03060 | — |
| Hassman Research Institute, LLC | Berlin | New Jersey | 08009 | — |
| Global Medical Institute, LLC | Princeton | New Jersey | 08540 | — |
| Bio Behavioral Health | Toms River | New Jersey | 08755 | — |
| Albuquerque Neuroscience, Inc | Albuquerque | New Mexico | 87109 | — |
| SPRI Clinical Trials, Inc | Brooklyn | New York | 11235 | — |
| Manhattan Behavioral Medicine | New York | New York | 10036 | — |
| Fieve Clinical Research | New York | New York | 10168 | — |
| New Hope Clinical Research Inc. | Charlotte | North Carolina | 28211 | — |
| Dr. Cherian Verghese | Norristown | Pennsylvania | 20006 | — |
| Research Strategies of Memphis, LLC | Memphis | Tennessee | 38119 | — |
| Houston Clinical Trials, LLC | Bellaire | Texas | 77401 | — |
| North Texas Clinical Trials | Fort Worth | Texas | 76104 | — |
| Grayline Clinical Drug Trials | Wichita Falls | Texas | 76309 | — |
| Psychiatric and Behavioral Solutions | Salt Lake City | Utah | 84105 | — |
| Department of Psychiatry and Neurobehavioral Sciences, University of Virginia | Charlottesville | Virginia | 22903 | — |
| Psychiatric Alliance of the Blue Ridge, Inc. | Charlottesville | Virginia | 22903 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02943577, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 13, 2019 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02943577 live on ClinicalTrials.gov.