Edoxaban Compared to Standard Care After Heart Valve Replacement Using a Catheter in Patients With Atrial Fibrillation (ENVISAGE-TAVI AF)
Public ClinicalTrials.gov record NCT02943785. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Edoxaban Versus Standard of Care and Their Effects on Clinical Outcomes in Patients Having Undergone Transcatheter Aortic Valve Implantation (TAVI) - in Atrial Fibrillation
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
When the upper chambers of a person's heart receive or generate irregular electrical signals, it causes abnormal rhythm in the heartbeat. This is called atrial fibrillation. Atrial fibrillation goes along with blood clots that may cause mainly strokes and less often other diseases, such as a heart attack. Some patients with atrial fibrillation have other heart disease, such as heart valves that may need to be replaced using catheters. Often doctors give patients drugs that reduce those blood clots. These are either vitamin K antagonist (VKA) or direct anticoagulants, such as edoxaban. In these patients, it is unclear which of the drugs is better for reducing stroke without increasing severe bleedings.
Study identification
- NCT ID
- NCT02943785
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,426 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 21, 2017 (Actual)
- Primary completion
- Feb 28, 2021 (Actual)
- Completion
- Feb 28, 2021 (Actual)
- Last update posted
- Mar 24, 2022
2017 – 2021
United States locations
- U.S. sites
- 66
- U.S. states
- 32
- U.S. cities
- 63
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| University of Arizona Sarver Heart Center | Tucson | Arizona | 85724 | — |
| Arkansas Site Management Services | Little Rock | Arkansas | 72211 | — |
| Loma Linda University Medical Center | Loma Linda | California | 92354 | — |
| Cedar-Sinai Heart Institute | Los Angeles | California | 90048 | — |
| UCLA Cardiovascular Center | Los Angeles | California | 90095 | — |
| University of California - San Francisco | San Francisco | California | 94143 | — |
| Santa Barbara Cottage Hospital | Santa Barbara | California | 93105-4365 | — |
| Medstar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Medical Facility Associates | Washington D.C. | District of Columbia | 20037 | — |
| Cardiology Associate Research | Daytona Beach | Florida | 32117 | — |
| International Research Partners, LLC. | Doral | Florida | 33166 | — |
| Memorial Healthcare Systems | Hollywood | Florida | 33021 | — |
| UF Health Jacksonville | Jacksonville | Florida | 32209 | — |
| Watson Clinic Center for Research | Lakeland | Florida | 33805 | — |
| Tallahassee Research Institute, Inc. | Tallahassee | Florida | 32308 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Carle Foundation Hospital | Urbana | Illinois | 61801 | — |
| St. Vincent Heart Center | Indianapolis | Indiana | 77030 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| Maine Medical Center | Scarborough | Maine | 04074-7133 | — |
| Washington Adventist Hospital | Takoma Park | Maryland | 20912 | — |
| Baystate Health | Springfield | Massachusetts | 01199 | — |
| University of Massachusetts Memorial Medical Center | Worcester | Massachusetts | 01655 | — |
| Sparrow Clinical Research Institute | Lansing | Michigan | 48912 | — |
| MidMichigan Medical Center Midland | Midland | Michigan | 48670 | — |
| Michigan Heart, St. Joseph Mercy Health System | Ypsilanti | Michigan | 48197 | — |
| Essentia Health | Duluth | Minnesota | 55805 | — |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905 | — |
| HealthEast Medical Research Institute | Saint Paul | Minnesota | 55104 | — |
| Jackson Heart Clinic | Jackson | Mississippi | 39216 | — |
| Clinical Investigators LLC | St Louis | Missouri | 63119 | — |
| Renown Regional Medical Center | Reno | Nevada | 89502 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| The Valley Hospital | Paramus | New Jersey | 07652 | — |
| New Mexico Heart Institute | Albuquerque | New Mexico | 87102 | — |
| NY Presbyterian - Brooklyn Methodist Hospital | Brooklyn | New York | 11215 | — |
| St. Francis Hospital | East Hills | New York | 11548 | — |
| St. Joseph's Physicians | East Syracuse | New York | 13057 | — |
| Rochester General Hospital | Geneva | New York | 14456 | — |
| Northshore Community Hospital | Manhasset | New York | 11030 | — |
| Mt. Sinai Hospital | New York | New York | 10029 | — |
| Stony Brook University Medical Center | Stony Brook | New York | 11794-8167 | — |
| Moses H. Cone Memorial Hospital Operating Corporation d/b/a Cone Health | Greensboro | North Carolina | 27401 | — |
| East Carolina Heart Institute | Greenville | North Carolina | 27834 | — |
| Promedica Toledo Hospital | Toledo | Ohio | 43615 | — |
| Oklahoma Heart Hospital Research Foundation | Oklahoma City | Oklahoma | 73120 | — |
| Southern Oregon Cardiology | Medford | Oregon | 97504 | — |
| Providence Heart and Vascular Institute | Portland | Oregon | 97225 | — |
| St. Luke's University Health Network | Bethlehem | Pennsylvania | 18015 | — |
| Doylestown Health Cardiothoracic Surgery | Doylestown | Pennsylvania | 18901 | — |
| Penn State Health, Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Geisinger Wyoming Valley Medical Center | Wilkes-Barre | Pennsylvania | 18711 | — |
| Pinnacle Health | Wormleysburg | Pennsylvania | 17043 | — |
| WellSpan York Hospital | York | Pennsylvania | 17403 | — |
| Black Hills Cardiovascular Research | Rapid City | South Dakota | 57701 | — |
| SCRI - Centennial Medical Center | Nashville | Tennessee | 37203 | — |
| Seton Heart Institute | Austin | Texas | 78745 | — |
| Houston Methodist Research Institute | Houston | Texas | 77030 | — |
| University of Texas Health Science Center Houston | Houston | Texas | 77030 | — |
| Legacy Heart Center | Plano | Texas | 75024 | — |
| Inova Heart and Vascular Institute | Falls Church | Virginia | 22042 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| Providence Sacred Heart Medical Research Center | Spokane | Washington | 99208 | — |
| CAMC Memorial Hospital | Charleston | West Virginia | 25404 | — |
| Aurora St. Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 164 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02943785, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 24, 2022 · Synced Nov 2, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02943785 live on ClinicalTrials.gov.