ClinicalTrials.gov record
Study To Compare Avelumab In Combination With Standard of Care Chemoradiotherapy (SoC CRT) Versus SoC CRT for Definitive Treatment In Patients With Locally Advanced Squamous Cell Carcinoma Of The Head And Neck (JAVELIN HEAD AND NECK 100)
ClinicalTrials.gov ID: NCT02952586
Public ClinicalTrials.gov record NCT02952586. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 19, 2026, 8:24 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A RANDOMIZED DOUBLE-BLIND PHASE 3 STUDY OF AVELUMAB IN COMBINATION WITH STANDARD OF CARE CHEMORADIOTHERAPY (CISPLATIN PLUS DEFINITIVE RADIATION THERAPY) VERSUS STANDARD OF CARE CHEMORADIOTHERAPY IN THE FRONT-LINE TREATMENT OF PATIENTS WITH LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK
Study identification
- NCT ID
- NCT02952586
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 697 participants
Conditions and interventions
Conditions
Interventions
- Avelumab Drug
- Chemoradiation Other
Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 27, 2016
- Primary completion
- Dec 22, 2019
- Completion
- Aug 24, 2020
- Last update posted
- Sep 21, 2021
2016 – 2020
United States locations
- U.S. sites
- 139
- U.S. states
- 25
- U.S. cities
- 94
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Highlands Oncology Group | Fayetteville | Arkansas | 72703 | — |
| Highlands Oncology Group | Rogers | Arkansas | 72758 | — |
| Highlands Oncology Group | Springdale | Arkansas | 72762 | — |
| The Oncology Institute of Hope and Innovation | Anaheim | California | 92801 | — |
| CBCC Global Research, Inc. at Comprehensive Blood and Cancer Center | Bakersfield | California | 93309 | — |
| Beverly Hills Cancer Center | Beverly Hills | California | 90211 | — |
| Tower Hematology Oncology Medical Group | Beverly Hills | California | 90211 | — |
| UCSD Radiation Oncology South Bay, Cancer Treatment Centers | Chula Vista | California | 91914 | — |
| City of Hope Corona | Corona | California | 92879 | — |
| Compassionate Care Research Group, Inc. at Compassionate Cancer Care Medical Group, Inc. | Corona | California | 92879 | — |
| The Oncology Institute of Hope and Innovation | Downey | California | 90241 | — |
| City of Hope (City of Hope National Medical Center, City of Hope Medical Center) | Duarte | California | 91010 | — |
| The Oncology Institute of Hope and Innovation | Glendale | California | 91204 | — |
| UC San Diego Medical Center- La Jolla (Thornton Hospital) | La Jolla | California | 92037 | — |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| City of Hope Antelope Valley | Lancaster | California | 93534 | — |
| The Oncology Institute of Hope and Innovation | Long Beach | California | 90805 | — |
| The Oncology Institute of Hope and Innovation | Los Angeles | California | 90033 | — |
| Cedars Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute | Los Angeles | California | 90048 | — |
| The Oncology Institute of Hope and Innovation | Lynwood | California | 90262 | — |
| The Oncology Institute of Hope and Innovation | Montebello | California | 90640 | — |
| UC Irvine Medical Center | Orange | California | 92868-3201 | — |
| Compassionate Care Research Group, Inc. at Compassionate Cancer Care Medical Group, Inc. | Riverside | California | 92501 | — |
| UC San Diego Medical Center- Hillcrest | San Diego | California | 92103 | — |
| The Oncology Institute of Hope and Innovation | Santa Ana | California | 92705 | — |
| City of Hope South Pasadena | South Pasadena | California | 91030 | — |
| The Oncology Institute of Hope and Innovation | Torrance | California | 90503 | — |
| The Oncology Institute of Hope and Innovation | West Covina | California | 91790 | — |
| The Oncology Institute of Hope and Innovation | Whittier | California | 90602 | — |
| Rocky Mountain Lions Eye Institute | Aurora | Colorado | 80045 | — |
| University of Colorado Denver CTO/CTRC | Aurora | Colorado | 80045 | — |
| University of Colorado Hospital - Anschutz Inpatient Pavilion | Aurora | Colorado | 80045 | — |
| University of Colorado Hospital - Anschutz Outpatient Pavilion | Aurora | Colorado | 80045 | — |
| University Of Colorado Hospital Cancer Center | Aurora | Colorado | 80045 | — |
| Cypress Hematology & Oncology | Denver | Colorado | 80210 | — |
| Cypress Hematology and Oncology | Parker | Colorado | 80138 | — |
| Sylvester at Coral Gables | Coral Gables | Florida | 33146 | — |
| Sylvester at Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| Specialist Global LLC | Hialeah | Florida | 33012 | — |
| Memorial Cancer Institute at Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Hollis Cancer Center | Lakeland | Florida | 33805 | — |
| Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | — |
| Memorial Cancer Institute at Memorial Hospital West | Pembroke Pines | Florida | 33028 | — |
| Sylvester at Plantation | Plantation | Florida | 33324 | — |
| H. Lee Moffitt Cancer Center and Research Institute | Tampa | Florida | 33612 | — |
| Primary Healthcare Associates | Flossmoor | Illinois | 60422 | — |
| Ingalls Memorial Hospital | Harvey | Illinois | 60426 | — |
| Primary Healthcare Associates | Harvey | Illinois | 60426 | — |
| Primary Healthcare Associates | Tinley Park | Illinois | 60477 | — |
| IU Health Arnett Cancer Center | Lafayette | Indiana | 47904 | — |
| Kansas City VA Radiation Oncology Clinic | Overland Park | Kansas | 66212 | — |
| Ashland-Bellefonte Cancer Center | Ashland | Kentucky | 41101 | — |
| Norton Cancer Institute | Louisville | Kentucky | 40202 | — |
| Norton Hospital | Louisville | Kentucky | 40202 | — |
| University Medical Center, Inc. | Louisville | Kentucky | 40202 | — |
| Norton Brownsboro Hospital | Louisville | Kentucky | 40241 | — |
| Norton Cancer Institute | Louisville | Kentucky | 40241 | — |
| Highlands Cancer Center | Prestonsburg | Kentucky | 41653 | — |
| Maryland Proton Treatment Center | Baltimore | Maryland | 21201 | — |
| University of Maryland School of Medicine | Baltimore | Maryland | 21201 | — |
| University of Maryland, Greenebaum Comprehensive Cancer Center | Baltimore | Maryland | 21201 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Karmanos Cancer Institute | Farmington Hills | Michigan | 48334 | — |
| Herbert-Herman Cancer Center, Sparrow Hospital | Lansing | Michigan | 48912 | — |
| Siteman Cancer Center- St. Peters | City of Saint Peters | Missouri | 63376 | — |
| University of Missouri- Ellis Fischel Cancer Center | Columbia | Missouri | 65212 | — |
| Siteman Cancer Center - West County | Creve Coeur | Missouri | 63141 | — |
| Kansas City VA Medical Center | Kansas City | Missouri | 64128 | — |
| Barnes-Jewish Hospital | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine Siteman Cancer Center | St Louis | Missouri | 63110 | — |
| Siteman Cancer Center - South County | St Louis | Missouri | 63129 | — |
| Department of Radiation Oncology Methodist Hospital | Omaha | Nebraska | 68114 | — |
| Oncology Hematology West, PC dba Nebraska Cancer Specialists | Omaha | Nebraska | 68114 | — |
| Memorial Sloan Kettering Cancer Center-Basking Ridge | Basking Ridge | New Jersey | 07920 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| John Theurer Cancer Center at Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Memorial Sloan Kettering Cancer Center- Monmouth | Middletown | New Jersey | 07748 | — |
| Memorial Sloan Kettering Cancer Center- Bergen | Montvale | New Jersey | 07645 | — |
| University of New Mexico Comprehensive Cancer Center | Albuquerque | New Mexico | 87131 | — |
| Memorial Sloan Kettering Cancer Center Commack | Commack | New York | 11725 | — |
| Memorial Sloan Kettering Cancer Center Westchester | Harrison | New York | 10604 | — |
| Bellevue Hospital Center | New York | New York | 10016 | — |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | 10016 | — |
| NYU Langone Medical Center | New York | New York | 10016 | — |
| NYU Langone Radiology | New York | New York | 10016 | — |
| NYU Langone Radiology - Ambulatory Care Center East 41st Street | New York | New York | 10017 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10022 | — |
| Memorial Sloan Kettering Cancer Center: Breast and Imaging Center | New York | New York | 10065 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| Stony Brook University | Stony Brook | New York | 11794-7007 | — |
| Stony Brook Cancer Center | Stony Brook | New York | 11794 | — |
| Montefiore-Einstein Center for Cancer Care | The Bronx | New York | 10461 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| Memorial Sloan Kettering Cancer Center- Nassau | Uniondale | New York | 11553 | — |
| Oncology Specialists of Charlotte, PA | Charlotte | North Carolina | 28204 | — |
| DJL Clinical Research, PLLC | Charlotte | North Carolina | 28210 | — |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27157 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| OU Medical Center | Oklahoma City | Oklahoma | 73104 | — |
| Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104 | — |
| University of Oklahoma Health Sciences Center- Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104 | — |
| Lehigh Valley Health Network Cancer Center Pharmacy | Allentown | Pennsylvania | 18103 | — |
| Lehigh Valley Health Network-Cedar Crest | Allentown | Pennsylvania | 18103 | — |
| Radiation Oncology Cancer Services | Allentown | Pennsylvania | 18103 | — |
| Lehigh Valley Health Network-Muhlenberg | Bethlehem | Pennsylvania | 18017 | — |
| Precision Cancer Research / Gettysburg Cancer Center | Gettysburg | Pennsylvania | 17325 | — |
| PinnacleHealth Cancer Institute | Harrisburg | Pennsylvania | 17109 | — |
| PinnacleHealth Cancer Institute | Jacksville | Pennsylvania | 17050 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC Shadyside Radiation Oncology | Pittsburgh | Pennsylvania | 15232 | — |
| MUSC- Rutledge Tower | Charleston | South Carolina | 29403 | — |
| Medical University of South Carolina- Hollings Cancer Center | Charleston | South Carolina | 29425 | — |
| MUSC SCTR Research Nexus Clinical Science Building | Charleston | South Carolina | 29425 | — |
| MUSC- Ashley River Tower | Charleston | South Carolina | 29425 | — |
| MUSC- Radiation Oncology | Charleston | South Carolina | 29425 | — |
| MUSC- University Hospital | Charleston | South Carolina | 29425 | — |
| GHS Cancer Institute | Easley | South Carolina | 29640 | — |
| GHS Cancer Institute | Greenville | South Carolina | 29605 | — |
| GHS Cancer Institute | Greenville | South Carolina | 29615 | — |
| GHS Cancer Institute | Greer | South Carolina | 29650 | — |
| GHS Cancer Institute | Seneca | South Carolina | 29672 | — |
| GHS Cancer Institute | Spartanburg | South Carolina | 29307 | — |
| The West Clinic, PC dba West Cancer Center | Germantown | Tennessee | 38138 | — |
| The West Clinic PC dba West Cancer Center | Memphis | Tennessee | 38104 | — |
| Henry-Joyce Cancer Clinic | Nashville | Tennessee | 37232 | — |
| Texas Oncology El Paso Cancer Treatment Center | El Paso | Texas | 79902 | — |
| William Beaumont Army Medical Center | El Paso | Texas | 79920-5001 | — |
| William Beaumont Army Medical Center | El Paso | Texas | 79920 | — |
| University of Texas Medical Branch | Galveston | Texas | 77555 | — |
| Memorial Hermann Hospital - TMC | Houston | Texas | 77030 | — |
| UTHealth/Memorial Hermann Cancer Center | Houston | Texas | 77030 | — |
| UTMB Cancer Center at Victory Lakes | League City | Texas | 77573 | — |
| Utah Cancer Specialists | Murray | Utah | 84157 | — |
| Utah Cancer Specialists | Salt Lake City | Utah | 84106 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| VA Puget Sound Health Care System | Seattle | Washington | 98108 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 177 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02952586, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 21, 2021 · Synced May 19, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT02952586 live on ClinicalTrials.gov.