A 24-Month Study to Evaluate the Efficacy and Safety of Elenbecestat (E2609) in Participants With Early Alzheimer's Disease
Public ClinicalTrials.gov record NCT02956486. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Placebo-Controlled, Double-Blind, Parallel-Group, 24 Month Study With an Open-Label Extension Phase to Evaluate the Efficacy and Safety of Elenbecestat (E2609) in Subjects With Early Alzheimer's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The name of this trial is MissionAD1. This phase 3 study consists of a Core and Open Label Extension (OLE) Phase in participants with Early Alzheimer's Disease (EAD), and will be conducted to evaluate the efficacy and safety of E2609. The Core is a 24-month treatment, multicenter, double blind, placebo controlled parallel group study. The OLE is a 24-month treatment, one group study. The data for the studies E2609-G000-301 (NCT02956486, MissionAD1) and E2609-G000-302 (NCT03036280, MissionAD2) will be pooled.
Study identification
- NCT ID
- NCT02956486
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,212 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 20, 2016 (Actual)
- Primary completion
- Jan 15, 2020 (Actual)
- Completion
- Jan 15, 2020 (Actual)
- Last update posted
- Feb 3, 2021
2016 – 2020
United States locations
- U.S. sites
- 88
- U.S. states
- 25
- U.S. cities
- 71
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Facility #1 | Chandler | Arizona | 85226 | — |
| Facility #1 | Colton | California | 92324 | — |
| Facility #1 | Costa Mesa | California | 92626 | — |
| Facility #1 | Fullerton | California | 92835 | — |
| Facility #1 | Imperial | California | 92251 | — |
| Facility #1 | Irvine | California | 92618 | — |
| Facility #1 | Lemon Grove | California | 91945 | — |
| Facility #1 | Oceanside | California | 92054 | — |
| Facility #2 | Oceanside | California | 92054 | — |
| Facility #1 | Oxnard | California | 93030 | — |
| Facility #1 | Panorama City | California | 91402 | — |
| Facility #1 | San Diego | California | 92123 | — |
| Facility #1 | Denver | Colorado | 80218 | — |
| Facility #1 | Atlantis | Florida | 33462 | — |
| Facility #1 | Aventura | Florida | 33187 | — |
| Facility #2 | Aventura | Florida | 33187 | — |
| Facility #1 | Boynton Beach | Florida | 33437 | — |
| Facility #1 | Coral Gables | Florida | 33134 | — |
| Facility #2 | Coral Gables | Florida | 33134 | — |
| Facility #1 | Delray Beach | Florida | 33445 | — |
| Facility #1 | Doral | Florida | 33122 | — |
| Facility #1 | Hialeah | Florida | 33016 | — |
| Facility #2 | Miami | Florida | 33122 | — |
| Facility #11 | Miami | Florida | 33125 | — |
| Facility #9 | Miami | Florida | 33125 | — |
| Facility #10 | Miami | Florida | 33126 | — |
| Facility #4 | Miami | Florida | 33133 | — |
| Facility #1 | Miami | Florida | 33137 | — |
| Facility #6 | Miami | Florida | 33144 | — |
| Facility #3 | Miami | Florida | 33155 | — |
| Facility #7 | Miami | Florida | 33174 | — |
| Facility #8 | Miami | Florida | 33176 | — |
| Facility #2 | Orlando | Florida | 32801 | — |
| Facility #1 | Orlando | Florida | 32806 | — |
| Facility #3 | Orlando | Florida | 32807 | — |
| Facility #1 | Palm Beach Gardens | Florida | 33410 | — |
| Facility #1 | Pompano Beach | Florida | 33064 | — |
| Facility #1 | Port Charlotte | Florida | 33952 | — |
| Facility #1 | Port Orange | Florida | 32127 | — |
| Facility #1 | Spring Hill | Florida | 34609 | — |
| Facility #1 | Tampa | Florida | 33613 | — |
| Facility #2 | Tampa | Florida | 33614 | — |
| Facility #1 | The Villages | Florida | 32162 | — |
| Facility #1 | Atlanta | Georgia | 30328 | — |
| Facility #1 | Columbus | Georgia | 31909 | — |
| Facility #1 | Decatur | Georgia | 30033 | — |
| Facility #1 | Suwanee | Georgia | 30024 | — |
| Facility #1 | Meridian | Idaho | 83642 | — |
| Facility #1 | Northbrook | Illinois | 60062 | — |
| Facility #2 | Wichita | Kansas | 67214 | — |
| Facility #1 | Boston | Massachusetts | 2115 | — |
| Facility #1 | Farmington Hills | Michigan | 48334 | — |
| Facility #1 | Chesterfield | Missouri | 63005 | — |
| Facility #1 | City of Saint Peters | Missouri | 63303 | — |
| Facility #1 | O'Fallon | Missouri | 63368 | — |
| Facility #2 | St Louis | Missouri | 63104 | — |
| Facility #1 | Mount Arlington | New Jersey | 7856 | — |
| Facility #2 | Springfield | New Jersey | 7081 | — |
| Facility #1 | West Long Branch | New Jersey | 7764 | — |
| Facility #1 | Amherst | New York | 14226 | — |
| Facility #1 | Brooklyn | New York | 11229 | — |
| Facility #1 | New York | New York | 10032 | — |
| Facility #1 | Canton | Ohio | 44718 | — |
| Facility #1 | Centerville | Ohio | 45459 | — |
| Facility #1 | Cleveland | Ohio | 44195 | — |
| Facility #1 | Dayton | Ohio | 45459 | — |
| Facility #1 | Lakewood | Ohio | 44107 | — |
| Facility #1 | Westerville | Ohio | 43081 | — |
| Facility #1 | Oklahoma City | Oklahoma | 73116 | — |
| Facility #1 | Portland | Oregon | 97210 | — |
| Facility #1 | Jenkintown | Pennsylvania | 19046 | — |
| Facility #1 | Media | Pennsylvania | 19063 | — |
| Facility #1 | Philadelphia | Pennsylvania | 19104 | — |
| Facility #1 | East Providence | Rhode Island | 02914 | — |
| Facility #1 | Providence | Rhode Island | 2906 | — |
| Facility #1 | Port Royal | South Carolina | 29935 | — |
| Facility #1 | Cordova | Tennessee | 38018 | — |
| Facility #2 | Nashville | Tennessee | 37203 | — |
| Facility #1 | Nashville | Tennessee | 37212 | — |
| Facility #1 | Austin | Texas | 78757 | — |
| Facility #1 | Dallas | Texas | 75231 | — |
| Facility #1 | Houston | Texas | 77084 | — |
| Facility #1 | San Antonio | Texas | 78229-3900 | — |
| Facility #3 | San Antonio | Texas | 78240 | — |
| Facility #1 | Salt Lake City | Utah | 84108 | — |
| Facility #1 | Bennington | Vermont | 5201 | — |
| Facility #1 | Hampton | Virginia | 23666 | — |
| Facility #1 | Madison | Wisconsin | 53705 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 170 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02956486, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 3, 2021 · Synced Oct 29, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02956486 live on ClinicalTrials.gov.