Efficacy of Eluxadoline in the Treatment of Irritable Bowel Syndrome With Diarrhea in Patients With Inadequate Control of Symptoms With Prior Loperamide Use
Public ClinicalTrials.gov record NCT02959983. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 4 Multicenter, Multinational, Prospective, Randomized, Placebo-Controlled, Double-Blinded Parallel Group Study to Assess Efficacy of Eluxadoline in the Treatment of Irritable Bowel Syndrome With Diarrhea (IBS-D) in Patients Who Report Inadequate Control of IBS-D Symptoms With Prior Loperamide Use (RELIEF)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the efficacy and safety of eluxadoline 100 milligrams (mg) twice a day (BID) versus placebo for the treatment of patients with Irritable Bowel Syndrome with Diarrhea (IBS-D) who report that the use of loperamide in the prior 12 months failed to provide control of their IBS-D symptoms.
Study identification
- NCT ID
- NCT02959983
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 346 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 25, 2016 (Actual)
- Primary completion
- Jan 22, 2018 (Actual)
- Completion
- Jan 22, 2018 (Actual)
- Last update posted
- Feb 15, 2019
2016 – 2018
United States locations
- U.S. sites
- 76
- U.S. states
- 26
- U.S. cities
- 69
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clinical Research Associates, LLC | Huntsville | Alabama | 35801 | — |
| The Center for Clinical Trials | Saraland | Alabama | 36571 | — |
| Elite Clinical Studies | Phoenix | Arizona | 85018 | — |
| Arkansas Gastroenterology | North Little Rock | Arkansas | 72117 | — |
| Med Investigations | Carmichael | California | 95608 | — |
| GW Research Inc | Chula Vista | California | 91910 | — |
| Diagnamics Inc | Encinitas | California | 92024 | — |
| Behavioral Research Specialists, LLC | Irvine | California | 92606 | — |
| Providence Clinical Research | North Hollywood | California | 91606 | — |
| Shahram Jacobs MD INC. | Sherman Oaks | California | 91403 | — |
| Westlake Medical Research | Thousand Oaks | California | 91360 | — |
| Upland Clinical Research | Upland | California | 91786 | — |
| Advanced RX Clinicial Research Group, Inc. | Westminster | California | 92683 | — |
| Connecticut Clinical Research Foundation | Bristol | Connecticut | 06010 | — |
| Medical Research Center of Connecticut, LLC | Hamden | Connecticut | 06518 | — |
| Innovative Research of West Florida, Inc. | Clearwater | Florida | 33756 | — |
| Digestive Care of N. Broward | Coral Springs | Florida | 33065 | — |
| Homestead Medical Research | Homestead | Florida | 33030 | — |
| Clinical Neuroscience Solutions Inc. | Jacksonville | Florida | 32256 | — |
| Health Awareness, Inc. | Jupiter | Florida | 33458 | — |
| Precision Clinical Research LLC | Lauderdale Lakes | Florida | 33319 | — |
| Pharmax Research Clinic Inc. | Miami | Florida | 33126 | — |
| Well Pharma Medical Research, Corp. | Miami | Florida | 33143 | — |
| Ocean Blue Medical Research Center, Inc | Miami Springs | Florida | 33166 | — |
| Bravo Health Care Center | North Bay Village | Florida | 33141 | — |
| Clinical Neuroscience Solutions Inc. | Orlando | Florida | 32801 | — |
| Clinical Research of West Florida Inc. | Tampa | Florida | 33603 | — |
| Meridien Research | Tampa | Florida | 33634 | — |
| Emory University School of Medicine | Atlanta | Georgia | 30322 | — |
| RNA America, LLC | Buford | Georgia | 30518 | — |
| Northwestern University Feinbery School of Medicine | Chicago | Illinois | 606611 | — |
| Pharmakon Inc | Evergreen Park | Illinois | 60805 | — |
| Investigators Research | Brownsburg | Indiana | 46112 | — |
| Radiant Research, Inc. | Evansville | Indiana | 47714 | — |
| Clinical Research Advantage Inc/Radiant Research Inc. | Evansville | Indiana | 47725 | — |
| Gtc Research | Shawnee Mission | Kansas | 66218 | — |
| Investigative Clinical Research | Annapolis | Maryland | 21401 | — |
| MGG Group Co. Inc. Chevy Chase Clinical Research | Chevy Chase | Maryland | 20815 | — |
| MedVadis Research Corporation | Watertown | Massachusetts | 02472 | — |
| Clinical Research Insititute of Michigan LLC | Chesterfield | Michigan | 48047 | — |
| Gastroenterology Associates of Western Michigan, PLC | Wyoming | Michigan | 49519 | — |
| The Center for Clinical Trials | Biloxi | Mississippi | 39531 | — |
| Women's Clinic of Lincoln, P.C. | Lincoln | Nebraska | 68510 | — |
| Quality Clinical Research Inc. | Omaha | Nebraska | 68114 | — |
| Advanced Biomedical Research of America | Las Vegas | Nevada | 89123 | — |
| Advanced Research Institute | Reno | Nevada | 89511 | — |
| Drug Trials Brooklyn | Brooklyn | New York | 11230 | — |
| NY Scientific | Brooklyn | New York | 11235 | — |
| Long Island Gastrointestinal Group LLP | Great Neck | New York | 11023 | — |
| IMA Medical Research, PC | Kew Gardens | New York | 11415 | — |
| Charlotte Gastroenterology & Hepatology, PLLC | Charlotte | North Carolina | 28207 | — |
| Peters Medical Research LLC | High Point | North Carolina | 27265 | — |
| North State Clincial Research PLLC | Lenoir | North Carolina | 28645 | — |
| Wake Research Associates LLC | Raleigh | North Carolina | 27612 | — |
| Trial Management Associates, LLC | Wilmington | North Carolina | 28403 | — |
| Clinical Inquest Center Ltd | Beavercreek | Ohio | 45431 | — |
| Hometown Urgent Care and Research | Cincinnati | Ohio | 45215 | — |
| Buckeye Health and Research | Columbus | Ohio | 43207 | — |
| Hometown Urgent Care and Research | Columbus | Ohio | 43214 | — |
| Hometown Urgent Care and Research | Huber Heights | Ohio | 45424 | — |
| Central Sooner Research | Norman | Oklahoma | 73071 | — |
| The Oregon Center for Clinical Investigations, INC. | Salem | Oregon | 97301 | — |
| Partners in Clinical Research | Cumberland | Rhode Island | 02864 | — |
| WR-ClinSearch, LLC | Chattanooga | Tennessee | 37421 | — |
| New Phase Research & Development | Knoxville | Tennessee | 37909 | — |
| CNS Healthcare | Memphis | Tennessee | 38119 | — |
| Premier Family Physicians | Austin | Texas | 78735 | — |
| Family Medicine Associate of Texas | Carrollton | Texas | 75010 | — |
| Multi-Phase Trials LLC | San Antonio | Texas | 78217 | — |
| Health Texas Research Institute | San Antonio | Texas | 78228 | — |
| Discovery Clinical Trials - Stone Oak | San Antonio | Texas | 78258 | — |
| Carl Meisner Medical Clinic | Sugar Land | Texas | 77478 | — |
| Advanced Research Institute - Ogden | Ogden | Utah | 84405 | — |
| Wasatch Clinical Research, LLC | Salt Lake City | Utah | 84107 | — |
| Gastroenterology Associates of Northern Virginia | Fairfax | Virginia | 22031 | — |
| Blue Ridge Medical Research | Lynchburg | Virginia | 24502 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02959983, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 15, 2019 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02959983 live on ClinicalTrials.gov.