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Terminated Phase 3 Interventional Results available

A Study of Lanabecestat (LY3314814) in Early Alzheimer's Disease Dementia

ClinicalTrials.gov ID: NCT02972658

Public ClinicalTrials.gov record NCT02972658. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 3, 2026, 9:09 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Double-Blind, Delayed-Start Study of LY3314814 (AZD3293) in Early Alzheimer's Disease Dementia (Extension of Study AZES, The AMARANTH Study)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study is an extension of study I8D-MC-AZES (NCT02245737), the AMARANTH study. The purpose of this study is to evaluate the effectiveness of the study drug lanabecestat in participants with early Alzheimer's disease dementia at the time of entry into study I8D-MC-AZES.

Study identification

NCT ID
NCT02972658
Recruitment status
Terminated
Study type
Interventional
Phase
Phase 3
Lead sponsor
AstraZeneca
Industry
Enrollment
421 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
55 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Mar 15, 2017 (Actual)
Primary completion
Oct 2, 2018 (Actual)
Completion
Oct 2, 2018 (Actual)
Last update posted
Dec 3, 2019

2017 – 2018

United States locations

U.S. sites
31
U.S. states
19
U.S. cities
31
Facility City State ZIP Site status
Banner Alzheimer's Institute Phoenix Arizona 85006 —
Territory Neurology & Research Institute Tucson Arizona 85704 —
Pacific Research Network Inc San Diego California 92103 —
Mile High Research Center Denver Colorado 80218 —
Institute for Neurodegenerative Disorders New Haven Connecticut 06510 —
Georgetown University Medical Center Washington D.C. District of Columbia 20057 —
Brain Matters Research Delray Beach Florida 33445 —
Compass Research Orlando Florida 32806 —
IMIC, Inc. Palmetto Bay Florida 33157 —
Roskamp Institute Sarasota Florida 34243 —
Suncoast Neuroscience Associates St. Petersburg Florida 33713 —
Premiere Research Institute at Palm Beach Neurology West Palm Beach Florida 33407 —
The Multiple Sclerosis Center of Atlanta Atlanta Georgia 30327 —
University of Chicago Medical Center Chicago Illinois 60637 —
Community Clinical Research Center Anderson Indiana 46011 —
Boston Center for Memory Newton Massachusetts 02459 —
Hattiesburg Clinic Hattiesburg Mississippi 39401 —
Memory Enhancement Center of America, Inc. Eatontown New Jersey 07724 —
The Cognitive and Research Center of NJ Springfield New Jersey 07081 —
Advanced Memory Research Institute of New Jersey Toms River New Jersey 08755 —
Integrative Clinical Trials, LLC Brooklyn New York 11229 —
Columbia University Medical Center New York New York 10032 —
University of Rochester School of Medicine Rochester New York 14620 —
Valley Medical Primary Care Centerville Ohio 45459 —
Lindner Research Center Cincinnati Ohio 45219 —
Ohio State University Medical Center Columbus Ohio 43210 —
Lehigh Valley Hospital Allentown Pennsylvania 18103 —
Rhode Island Mood & Memory Research Institute East Providence Rhode Island 02914 —
Radiant Research Greer South Carolina 29651 —
Quillen College of Medicine, East TN State University Johnson City Tennessee 37604 —
The Memory Clinic Bennington Vermont 05201 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 102 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT02972658, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Dec 3, 2019 · Synced Oct 3, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT02972658 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →