Transformative Research in Diabetic Nephropathy

ClinicalTrials.gov ID: NCT02986984

Public ClinicalTrials.gov record NCT02986984. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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Official title

Transformative Research In DiabEtic NephropaThy

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a prospective, observational, cohort study of patients with a clinical diagnosis of diabetes who are undergoing clinically indicated kidney biopsy. The intent is to collect, process, and study kidney tissue and to harvest blood, urine and genetic materials to elucidate molecular pathways and link them to biomarkers that characterize those patients have a rapid decline in kidney function (\> 5 mL/min/1.73m2/year) from those with lesser degrees of kidney function change over the period of observation. High through-put genomic analysis associated with genetic and biomarker testing will serve to identify key potential therapeutic targets for DKD by comparing patients with rapid and slow progression patterns. Each participating clinical site will search for, consent, harvest the biopsy sample, and enroll the participants as required for the TRIDENT protocol.

Study identification

NCT ID: NCT02986984
Recruitment status: Recruiting
Study type: Observational
Phase: Not listed
Lead sponsor: University of Pennsylvania; Other
Enrollment: 400 participants

Conditions and interventions

Conditions

Interventions

There is no intervention Other

Other

Eligibility (public fields only)

Age range: 18 Years to 100 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Nov 30, 2016
Primary completion: May 31, 2027
Completion: May 31, 2027
Last update posted: Feb 26, 2026

2016 – 2027

United States locations

U.S. sites: 17
U.S. states: 13
U.S. cities: 16

Facility	City	State	ZIP	Site status
University of Arkansas for Medical Sciences	Little Rock	Arkansas	72205	Recruiting
University of Southern California	Los Angeles	California	90033	Active, not recruiting
Stanford University	Palo Alto	California	—	Recruiting
Yale University	New Haven	Connecticut	06510	Recruiting
Northwestern University	Chicago	Illinois	60611	Recruiting
University of Michigan	Ann Arbor	Michigan	48109	Active, not recruiting
University of New Mexico	Albuquerque	New Mexico	87131	Recruiting
Mount Sinai Hospital	New York	New York	10029	Recruiting
Columbia University	New York	New York	10032	Active, not recruiting
Albert Einstein College of Medicine	The Bronx	New York	10461	Active, not recruiting
University of North Carolina	Chapel Hill	North Carolina	27599	Recruiting
Ohio State University	Columbus	Ohio	43210	Recruiting
Oregon Health & Science University	Portland	Oregon	97239	Recruiting
Lehigh Valley Health Network	Allentown	Pennsylvania	18103	Recruiting
University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
University of Texas Health Science Center at San Antonio	San Antonio	Texas	78229	Recruiting
University of Virginia	Charlottesville	Virginia	22908	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT02986984, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 26, 2026 · Synced Sep 6, 2026

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