Investigating the Use of Genetics to Guide Pharmacologic Therapy for Hypertension
Public ClinicalTrials.gov record NCT02988245. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
Prospective Randomized Controlled Trial Investigating the Use of Genetic Predisposition to Guide Pharmacologic Therapy for Hypertension
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Hypertension is one of the most important preventable contributors to disease and death in the United States and represents the most common condition seen in the primary care setting. Approximately 78 million adults living in the U.S. have hypertension with more than 5 million new diagnoses made each year. Unfortunately, despite a significant impulse in the medical community to move towards an "individualized medicine" approach to patient centered treatment, the current clinical treatment strategy is based on a set algorithm which does not take into account individual patient differences. As a result hypertension is often sub-optimally treated based on "population averages", rather than a person's genetic make-up, with significant burden on our health care system. In fact, 40% of patients who are adherent to their blood pressure therapy (taking their medicines as prescribed by their clinician) do not have their blood pressure under control. Previous work has demonstrated significant functional polymorphisms within the kidney, vessels, and heart that will likely predict a patient's response to blood pressure pharmacotherapy. Previous work by our group, utilizing a retrospective design, has determined that the addition of genetic knowledge to prescribing can improve therapeutic guidance and decrease the time to blood pressure control significantly. Despite this, to date, there are no prospective trials to guide blood pressure therapy using multiple organ systems that are important in the three most common classes of drugs: diuretics, vasodilators, and beta-blockers. The objective of this clinical trial is to determine the efficacy of genetically guided therapeutic options for pharmacologic treatment of essential hypertension in newly diagnosed patients.
Study identification
- NCT ID
- NCT02988245
- Recruitment status
- Not listed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 1,000 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 30 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2022 (Estimated)
- Primary completion
- May 2023 (Estimated)
- Completion
- Dec 2023 (Estimated)
- Last update posted
- Feb 2, 2022
2022 – 2023
United States locations
- U.S. sites
- 15
- U.S. states
- 1
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Fairview Health Clinics - Andover | Andover | Minnesota | 55304 | — |
| Fairview Health Clinics - Blaine | Blaine | Minnesota | 55449 | — |
| Fairview Health Clinics - Bloomington, Oxboro | Bloomington | Minnesota | 55420 | — |
| Fairview Clinics - Brooklyn Park | Brooklyn Park | Minnesota | 55443 | — |
| Fairview Clinics- Burnsville | Burnsville | Minnesota | 55337 | — |
| Fairview Clinics - Columbia Heights | Columbia Heights | Minnesota | 55421 | — |
| Fairview Health Clinics - Edina | Edina | Minnesota | 55345 | — |
| Fairview Health Clinics - Elk River | Elk River | Minnesota | 55330 | — |
| Fairview Clinics - Fridley | Fridley | Minnesota | 55432 | — |
| Fairview Clinics - Lino Lakes | Lino Lakes | Minnesota | 55014 | — |
| Fairview Clinics - Hiawatha | Minneapolis | Minnesota | 55406 | — |
| Fairview Clinic - New Brighton | New Brighton | Minnesota | 55112 | — |
| Fairview Clinics - North Branch | North Branch | Minnesota | 55056 | — |
| Fairview Clinics - Wyoming | Wyoming | Minnesota | 55092 | — |
| Fairview Health Services - Zimmerman | Zimmerman | Minnesota | 55398 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02988245, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 2, 2022 · Synced Nov 9, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02988245 live on ClinicalTrials.gov.