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Completed Phase 1Phase 2 Interventional Results available

Enapotamab Vedotin (HuMax-AXL-ADC) Safety Study in Patients With Solid Tumors

ClinicalTrials.gov ID: NCT02988817

Public ClinicalTrials.gov record NCT02988817. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 31, 2026, 7:29 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

First-in-human, Open-label, Dose-escalation Trial With Expansion Cohorts to Evaluate Safety of Axl-specific Antibody-drug Conjugate (Enapotamab Vedotin, HuMax®-AXL-ADC) in Patients With Solid Tumors

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of the trial is to determine the maximum tolerated dose and to establish the safety profile of HuMax-AXL-ADC in a mixed population of patients with specified solid tumors

Study identification

NCT ID
NCT02988817
Recruitment status
Completed
Study type
Interventional
Phase
Phase 1, Phase 2
Lead sponsor
Genmab
Industry
Enrollment
306 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Nov 23, 2016 (Actual)
Primary completion
Nov 12, 2021 (Actual)
Completion
Nov 12, 2021 (Actual)
Last update posted
Aug 1, 2023

2016 – 2021

United States locations

U.S. sites
20
U.S. states
16
U.S. cities
19
Facility City State ZIP Site status
Mayo Clinic - Phoenix Phoenix Arizona 85054 —
University of Colorado Hospital Aurora Colorado 80045 —
Yale University, Smilow Cancer Center at Yale New Haven Hospital New Haven Connecticut 06520 —
Mayo Clinic Jacksonville Jacksonville Florida 32224 —
Moffitt Cancer Center Tampa Florida 33612 —
Emory University School of Medicine, Winship Cancer Institute Atlanta Georgia 30322 —
University of Iowa Iowa City Iowa 52242 —
Dana-Farber Cancer Institute Boston Massachusetts 02115 —
University of Michigan Comprehensive Cancer Center Ann Arbor Michigan 48109 —
Mayo Clinic Rochester Rochester Minnesota 55905 —
Washington University St Louis Missouri 63110 —
Roswell Park Comprehensive Cancer Center Buffalo New York 14263 —
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York 10016 —
Herbert Irving Comprehensive Cancer Center New York New York 10034 —
Duke Cancer Institute Durham North Carolina 27710 —
Fox Chase Cancer Center Philadelphia Pennsylvania 19111 —
Mary Crowley Cancer Research Center Dallas Texas 75230 —
University of Texas MD Anderson Cancer Center Houston Texas 77030 —
University of Utah Huntsman Cancer Institute Salt Lake City Utah 84112 —
University of Wisconsin Carbone Cancer Center Madison Wisconsin 53792 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 21 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT02988817, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 1, 2023 · Synced Oct 31, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT02988817 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →