A Neoadjuvant Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Versus Chemotherapy Alone in Early Stage Non-Small Cell Lung Cancer (NSCLC)
Public ClinicalTrials.gov record NCT02998528. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized, OpenLabel, Phase 3 Trial of Nivolumab Plus Ipilimumab or Nivolumab Plus Platinum Doublet Chemotherapy Versus Platinum Doublet Chemotherapy in Early Stage NSCLC
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this neoadjuvant study is to compare nivolumab plus chemotherapy and chemotherapy alone in terms of safety and effectiveness, and to describe nivolumab plus ipilimumab's safety and effectiveness in treating resectable NSCLC. This study has multiple primary endpoints.
Study identification
- NCT ID
- NCT02998528
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 505 participants
Conditions and interventions
Conditions
Interventions
- Nivolumab Biological
- Cisplatin Drug
- Vinorelbine Drug
- Gemcitabine Drug
- Docetaxel Drug
- Pemetrexed Drug
- Carboplatin Drug
- Paclitaxel Drug
- Ipilimumab Biological
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 4, 2017 (Actual)
- Primary completion
- Sep 8, 2021 (Actual)
- Completion
- Dec 6, 2024 (Actual)
- Last update posted
- Jan 6, 2026
2017 – 2024
United States locations
- U.S. sites
- 57
- U.S. states
- 28
- U.S. cities
- 51
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 0121 | Glendale | Arizona | 85308 | — |
| Local Institution - 0081 | Los Angeles | California | 90017 | — |
| Local Institution - 0025 | Denver | Colorado | 80218 | — |
| Local Institution - 0007 | Plainville | Connecticut | 06062 | — |
| Local Institution - 0173 | Hollywood | Florida | 33021 | — |
| Local Institution - 0136 | Miami | Florida | 33136 | — |
| Local Institution - 0054 | Orlando | Florida | 32804 | — |
| Orlando Health, Inc. | Orlando | Florida | 32806 | — |
| Indian River Medical Center | Vero Beach | Florida | 32960 | — |
| Northwest Georgia Oncology Center, P.C. | Marietta | Georgia | 30060 | — |
| Local Institution - 0015 | Chicago | Illinois | 60611 | — |
| Local Institution - 0002 | Chicago | Illinois | 60637 | — |
| Illinois Cancer Specialists | Niles | Illinois | 60714 | — |
| Local Institution - 0171 | Fort Wayne | Indiana | 46804 | — |
| Local Institution - 0170 | Lexington | Kentucky | 40536 | — |
| Local Institution - 0186 | Louisville | Kentucky | 40202 | — |
| University Medical Center New Orleans | New Orleans | Louisiana | 70112 | — |
| Local Institution - 0151 | Baltimore | Maryland | 21237 | — |
| Local Institution - 0001 | Baltimore | Maryland | 21287 | — |
| Local Institution - 0008 | Boston | Massachusetts | 02215 | — |
| Southcoast Center For Cancer | Fairhaven | Massachusetts | 02719 | — |
| Local Institution - 0006 | Newton | Massachusetts | 02459 | — |
| Local Institution - 0012 | Detroit | Michigan | 48202-2608 | — |
| Local Institution - 0090 | Hattiesburg | Mississippi | 39401 | — |
| St Vincent Frontier Cancer Center | Billings | Montana | 59102 | — |
| Local Institution - 0032 | Las Vegas | Nevada | 89128 | — |
| Local Institution - 0009 | Hackensack | New Jersey | 07601 | — |
| Valley Hospital Luckow Pavili | Westwood | New Jersey | 07675 | — |
| Local Institution - 0027 | Albany | New York | 12208 | — |
| Local Institution - 0011 | New York | New York | 10016 | — |
| Local Institution - 0140 | High Point | North Carolina | 27262 | — |
| Christ Hospital | Cincinnati | Ohio | 45219 | — |
| MetroHealth Medical Center | Cleveland | Ohio | 44109 | — |
| Local Institution - 0149 | Zanesville | Ohio | 43701 | — |
| Kaiser Permanente | Portland | Oregon | 97227 | — |
| Local Institution - 0139 | Portland | Oregon | 97239 | — |
| Local Institution - 0010 | Philadelphia | Pennsylvania | 19111 | — |
| Local Institution - 0018 | Pittsburgh | Pennsylvania | 15212 | — |
| Local Institution - 0013 | Charleston | South Carolina | 29414 | — |
| Local Institution - 0021 | Charleston | South Carolina | 29425 | — |
| Local Institution - 0146 | Greenville | South Carolina | 29607 | — |
| Local Institution - 0092 | Nashville | Tennessee | 37203 | — |
| Local Institution - 0005 | Nashville | Tennessee | 37232 | — |
| Local Institution - 0035 | Austin | Texas | 78745 | — |
| Texas Oncology | Bedford | Texas | 76022 | — |
| Local Institution - 0153 | Fort Bliss | Texas | 79918 | — |
| Local Institution - 0106 | Houston | Texas | 77090 | — |
| Southwest Cancer Center | Lubbock | Texas | 79415 | — |
| Texas Cancer Center - Sherman | Sherman | Texas | 75090-0504 | — |
| Local Institution - 0143 | Tyler | Texas | 75701 | — |
| Local Institution - 0026 | Waco | Texas | 76712 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| Local Institution - 0003 | Salt Lake City | Utah | 84112 | — |
| Southwest Regional Cancer Clinic | St. George | Utah | 84770 | — |
| Local Institution - 0135 | Burlington | Vermont | 05405 | — |
| Local Institution - 0125 | Fairfax | Virginia | 22031 | — |
| Local Institution - 0198 | Fredericksburg | Virginia | 22408 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 81 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT02998528, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 6, 2026 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT02998528 live on ClinicalTrials.gov.