A Study of RO7123520 to Evaluate the Safety and Efficacy in Participants With Moderately To Severely Active Rheumatoid Arthritis (RA) Who Are Inadequately Responding to Anti-Tumor Necrosis Factor (TNF)-Alpha Therapy
Public ClinicalTrials.gov record NCT03001219. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Phase II Study to Evaluate The Safety and Efficacy of RO7123520 as Adjunct Treatment in Patients With Moderately to Severely Active Rheumatoid Arthritis and an Inadequate Response to TNF-alpha Inhibitors
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase IIa/b double-blind, placebo-controlled, randomized, parallel group, multicenter study to evaluate the safety and efficacy of RO7123520 as adjunctive therapy in participants with RA who are inadequately responding to standard-of-care (methotrexate and anti-TNF-alpha therapy). Part 1 of the study will evaluate safety. Part 2 will evaluate efficacy and safety. Part 3 will evaluate dose-ranging efficacy. Participants will have the option of continuing to the extension period of the study.
Study identification
- NCT ID
- NCT03001219
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 109 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 21, 2016
- Primary completion
- Nov 5, 2018
- Completion
- Nov 5, 2018
- Last update posted
- Jan 28, 2020
2016 – 2018
United States locations
- U.S. sites
- 32
- U.S. states
- 14
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group; Llc, Central | Anniston | Alabama | 36207 | — |
| Arizona Arthritis & Rheumatology Associates, P.C. | Glendale | Arizona | 85306 | — |
| Arizona Arthritis and Rheuma | Mesa | Arizona | 85202 | — |
| Arizona Arthritis & Rheumatology Research, PLLC | Phoenix | Arizona | 85037 | — |
| Medvin Clinical Research | Covina | California | 91723 | — |
| University of California San Diego | La Jolla | California | 92093 | — |
| Advanced Medical Research, LLC | Lakewood | California | 90712 | — |
| Stanford hospital & Clinics; Investigational Drug Services | Stanford | California | 94304 | — |
| Omega Research Consultants LLC | DeBary | Florida | 32713-1817 | — |
| San Marcus Research Clinic, Inc. | Hialeah | Florida | 33015-5110 | — |
| Millenium Research | Ormond Beach | Florida | 32174 | — |
| Clinical Pharmacology Study Group | Worcester | Massachusetts | 01610 | — |
| Shores Rheumatology PC | Saint Clair Shores | Michigan | 48080 | — |
| Arthritis & Osteoporosis Associates | Freehold | New Jersey | — | — |
| Atlantic Coast Rheumatology | Toms River | New Jersey | 08755 | — |
| Ocean Rheumatology | Toms River | New Jersey | 08775 | — |
| Albuquerque Center For Rheumatology | Albuquerque | New Mexico | 87102 | — |
| Albuquerque Clinical Trials | Albuquerque | New Mexico | 87102 | — |
| Saint Lawrence Health System; Rheumatology | Canton | New York | 13617 | — |
| Paramount Medical Research | Middleburg Heights | Ohio | 44130 | — |
| Altoona Center For Clinical Research | Duncansville | Pennsylvania | 16635 | — |
| Advanced Rheumatology & Arthritis Research Center | Wexford | Pennsylvania | 15090 | — |
| Low Country Rheumatology, PA | Charleston | South Carolina | 29406 | — |
| Columbia Arthritis Center (Partnership Practice) | Columbia | South Carolina | 29204 | — |
| West Tennessee Research Institute | Jackson | Tennessee | 38305 | — |
| Adriana Pop-Moody MD Clinic PA | Corpus Christi | Texas | 78404 | — |
| Metroplex Clinical Research | Dallas | Texas | 75231 | — |
| Pioneer Research Solutions | Houston | Texas | 077099 | — |
| Accurate Clinical Research | Houston | Texas | 77058-3675 | — |
| Accurate Clinical Research | Houston | Texas | 77089 | — |
| Southwest Rheumatology | Mesquite | Texas | 75150 | — |
| Accurate Clinical Research, Inc | Stafford | Texas | 77477 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 49 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03001219, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 28, 2020 · Synced Sep 10, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03001219 live on ClinicalTrials.gov.