ClinicalTrials.gov record
A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC)
ClinicalTrials.gov ID: NCT03006068
Public ClinicalTrials.gov record NCT03006068. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Multicenter, Long-Term Extension Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) in Subjects With Ulcerative Colitis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is designed to evaluate the long-term safety and efficacy of Upadacitinib in participants with ulcerative colitis (UC) who have not responded at the end of the induction period in Study M14-234 Substudy 1, who have had loss of response during the maintenance period of Study M14-234 Substudy 3, or who have successfully completed Study M14-234 Substudy 3.
Study identification
- NCT ID
- NCT03006068
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 950 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 16 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 31, 2017 (Actual)
- Primary completion
- Jul 2027 (Estimated)
- Completion
- Jul 2027 (Estimated)
- Last update posted
- Jan 12, 2026
2017 – 2027
United States locations
- U.S. sites
- 147
- U.S. states
- 37
- U.S. cities
- 114
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| East View Medical Research, LLC /ID# 171184 | Mobile | Alabama | 36606 | — |
| CB Flock Research Corporation /ID# 165986 | Mobile | Alabama | 36608 | — |
| Delsol Research Management, Ll /Id# 170130 | Chandler | Arizona | 85224 | — |
| Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211886 | Mesa | Arizona | 85206 | — |
| Duplicate_Arizona Arthritis & Rheumatology Research, PLLC /ID# 169823 | Sun City | Arizona | 85306 | — |
| Adobe Clinical Research LLC /ID# 155249 | Tucson | Arizona | 85712 | — |
| Duplicate_University of Arizona /ID# 150568 | Tucson | Arizona | 85724 | — |
| Citrus Valley Gastroenterology /ID# 151915 | Covina | California | 91722-3797 | — |
| Newport Huntington Medical Group /ID# 217006 | Huntington Beach | California | 92648-5994 | — |
| UC San Diego Health System /ID# 155187 | La Jolla | California | 92037 | — |
| United Medical Doctors /ID# 207467 | Los Alamitos | California | 90720-3309 | — |
| TLC Clinical Research Inc /ID# 216830 | Los Angeles | California | 90048 | — |
| Gastrointestinal Biosciences Clinical Trials, LLC /ID# 157082 | Los Angeles | California | 90067-2001 | — |
| Facey Medical Foundation /ID# 203135 | Mission Hills | California | 91345 | — |
| United Medical Doctors - Murrieta /ID# 151213 | Murrieta | California | 92563 | — |
| Ventura County Gastroenterology Medical Group /ID# 163417 | Oxnard | California | 93030-0190 | — |
| Inland Empire Clinical Trials, LLC /ID# 216163 | Rialto | California | 92377 | — |
| San Diego Clinical Trials /ID# 212121 | San Diego | California | 92120 | — |
| Medical Assoc Research Grp /ID# 169149 | San Diego | California | 92123 | — |
| Univ of California San Francis /ID# 164583 | San Francisco | California | 94158 | — |
| Delta Waves, Inc. /ID# 151727 | Colorado Springs | Colorado | 80918 | — |
| South Denver Gastroenterology /ID# 151224 | Lone Tree | Colorado | 80124 | — |
| Western States Clinical Res /ID# 158078 | Wheat Ridge | Colorado | 80033-2896 | — |
| Duplicate_Western Connecticut Medical Group /ID# 169211 | Danbury | Connecticut | 06810 | — |
| Gastroenterology Center of Connecticut /ID# 150534 | Hamden | Connecticut | 06518 | — |
| West Central Gastroenterology /ID# 155242 | Clearwater | Florida | 33762 | — |
| Moonshine Research Center, Inc /ID# 152534 | Doral | Florida | 33166 | — |
| Universal Axon Clinical Research /ID# 213463 | Doral | Florida | 33166 | — |
| Palmetto Research, LLC /ID# 151724 | Hialeah | Florida | 33016 | — |
| Nature Coast Clinical Research - Inverness /ID# 154070 | Inverness | Florida | 34452-4717 | — |
| Encore Borland-Groover Clinical Research /Id# 170913 | Jacksonville | Florida | 32256 | — |
| SIH Research Mumtaz, Inc /ID# 163199 | Kissimmee | Florida | 34741-4161 | — |
| Cfagi Llc /Id# 202018 | Maitland | Florida | 32751-6108 | — |
| Duplicate_University of Miami /ID# 215443 | Miami | Florida | 33136 | — |
| Advanced Pharma CR, LLC /ID# 151723 | Miami | Florida | 33147 | — |
| New Horizon Research Center /ID# 152475 | Miami | Florida | 33165-3372 | — |
| Crystal Pharmacology Research /ID# 151848 | Miami | Florida | 33165 | — |
| Coral Research Clinic /ID# 150524 | Miami | Florida | 33186-4643 | — |
| Advanced Research Institute, Inc /ID# 163093 | New Port Richey | Florida | 34653 | — |
| Endoscopic Research, Inc. /ID# 151725 | Orlando | Florida | 32803 | — |
| Omega Research Group /ID# 200271 | Orlando | Florida | 32808 | — |
| Clinical Research Trials of Florida, Inc. /ID# 201791 | Tampa | Florida | 33607 | — |
| Duplicate_University of South Florida /ID# 214494 | Tampa | Florida | 33612 | — |
| Duplicate_AdventHealth Tampa /ID# 200274 | Tampa | Florida | 33613-4680 | — |
| Gastroenterology Associates of Central Georgia, LLC /ID# 165783 | Macon | Georgia | 31201 | — |
| Infinite Clinical Trials /ID# 215342 | Riverdale | Georgia | 30274 | — |
| Atlanta Gastroenterology Spec /ID# 150565 | Suwanee | Georgia | 30024 | — |
| Next Innovative Clinical Research - Chicago /ID# 217323 | Chicago | Illinois | 60605-2168 | — |
| Duplicate_The University of Chicago DCAM /ID# 150564 | Chicago | Illinois | 60637 | — |
| Duplicate_NorthShore University HealthSystem /ID# 150570 | Evanston | Illinois | 60201 | — |
| Northwest Health Care Associates /ID# 151591 | Hoffman Estates | Illinois | 60169 | — |
| Carle Foundation Hospital /ID# 151155 | Urbana | Illinois | 61801 | — |
| MediSphere Medical Research Center /ID# 152080 | Evansville | Indiana | 47714-8011 | — |
| Indianapolis Gastroenterology /ID# 162914 | Indianapolis | Indiana | 46237 | — |
| University of Iowa Hospitals and Clinics /ID# 157059 | Iowa City | Iowa | 52242 | — |
| Cotton O'Neil Clinical Research Center, Digestive Health /ID# 167183 | Topeka | Kansas | 66606 | — |
| Tri-State Gastroenterology /ID# 169812 | Crestview Hills | Kentucky | 41017 | — |
| Houma Digestive Health Special /ID# 151851 | Houma | Louisiana | 70360 | — |
| Nola Research Works, LLC /ID# 153365 | New Orleans | Louisiana | 70115 | — |
| Louisiana Research Center, LLC /ID# 150526 | Shreveport | Louisiana | 71105-6800 | — |
| University of Maryland, Baltimore /ID# 150529 | Baltimore | Maryland | 21201 | — |
| Gastro Center of Maryland /ID# 200024 | Columbia | Maryland | 21045 | — |
| Massachusetts General Hospital /ID# 165678 | Boston | Massachusetts | 02114 | — |
| University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 151158 | Ann Arbor | Michigan | 48109 | — |
| Huron Gastroenterology Assoc /ID# 152712 | Ann Arbor | Michigan | 48197 | — |
| Clin Res Inst of Michigan, LLC /ID# 153031 | Chesterfield | Michigan | 48047 | — |
| Clin Res Inst of Michigan, LLC /ID# 161983 | Chesterfield | Michigan | 48047 | — |
| Revival Research Institute, LLC /ID# 207281 | Southfield | Michigan | 48034-1659 | — |
| Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 157487 | Wyoming | Michigan | 49519 | — |
| Mayo Clinic - Rochester /ID# 151681 | Rochester | Minnesota | 55905-0001 | — |
| Minnesota Gastroenterology PA /ID# 151682 | Saint Paul | Minnesota | 55114 | — |
| University of Mississippi Medical Center /ID# 213140 | Jackson | Mississippi | 39216-4500 | — |
| Southern Therapy and Advanced Research (STAR) LLC /ID# 170713 | Jackson | Mississippi | 39216 | — |
| Washington University-School of Medicine /ID# 150537 | St Louis | Missouri | 63110 | — |
| Vector Clinical Trials /ID# 153052 | Las Vegas | Nevada | 89128 | — |
| Dartmouth-Hitchcock Medical Center /ID# 150566 | Lebanon | New Hampshire | 03756 | — |
| Cooper Gastroenterology at Fire Road /ID# 153048 | Egg Harbor | New Jersey | 08234 | — |
| Atlantic Digestive Health Inst /ID# 150527 | Morristown | New Jersey | 07960 | — |
| Rutgers Robert Wood Johnson /ID# 155247 | New Brunswick | New Jersey | 08901 | — |
| Duplicate_University of New Mexico Department of Internal Medicine /ID# 214399 | Albuquerque | New Mexico | 87131 | — |
| NY Scientific /ID# 152708 | Brooklyn | New York | 11235 | — |
| Duplicate_NYU Langone Long Island Clinical Research Association /ID# 155271 | Great Neck | New York | 11021 | — |
| Columbia Univ Medical Center /ID# 163409 | New York | New York | 10032-3725 | — |
| Duplicate_DiGiovanna Institute for Medical Education & Research /ID# 201534 | North Massapequa | New York | 11758 | — |
| Premier Medical Group - GI Division /ID# 153366 | Poughkeepsie | New York | 12601 | — |
| Gastoenterology Group of Rochester /ID# 151080 | Rochester | New York | 14618-5703 | — |
| Richmond University Medical Center /ID# 201860 | Staten Island | New York | 10310-1664 | — |
| Montefiore Medical Center - Moses Campus /ID# 150559 | The Bronx | New York | 10467 | — |
| Advantage Clinical Trials /ID# 163940 | The Bronx | New York | 10468 | — |
| Digestive Health Partners - Biltmore Office /ID# 167238 | Asheville | North Carolina | 28801 | — |
| Atrium Health Carolinas Medical Center /ID# 157060 | Charlotte | North Carolina | 28203 | — |
| Charlotte Gastroenterology and Hepatology, PLLC /ID# 150561 | Charlotte | North Carolina | 28207 | — |
| Atlantic Gastroenterology Clinical Research /ID# 151901 | Greenville | North Carolina | 27834 | — |
| Clinical Trials of America /ID# 153453 | Winston-Salem | North Carolina | 27103 | — |
| Duplicate_Atrium Health Wake Forest Baptist Medical Center /ID# 150528 | Winston-Salem | North Carolina | 27157-0001 | — |
| Plains Clinical Research Center, LLC /ID# 170291 | Fargo | North Dakota | 58104-5925 | — |
| Gastro Health Research /ID# 151683 | Cincinnati | Ohio | 45219 | — |
| University Of Cincinnati Medical Center /ID# 164584 | Cincinnati | Ohio | 45219 | — |
| The Ohio State University /ID# 169417 | Columbus | Ohio | 43210 | — |
| Optimed Research, Ltd. /ID# 169697 | Columbus | Ohio | 43235 | — |
| Hometown Urgent Care and Resea /ID# 200066 | Dayton | Ohio | 45424 | — |
| Dayton Gastroenterology, Inc. /ID# 167632 | Englewood | Ohio | 45415 | — |
| Great Lakes Gastroenterology Research, LLC /ID# 201773 | Mentor | Ohio | 44060-6211 | — |
| Ohio Clinical Research Partner /ID# 154074 | Mentor | Ohio | 44060 | — |
| Hightower Clinical /ID# 216338 | Oklahoma City | Oklahoma | 73102 | — |
| Digestive Disease Specialists /ID# 201057 | Oklahoma City | Oklahoma | 73112 | — |
| Options Health Research, LLC /ID# 150569 | Tulsa | Oklahoma | 74104 | — |
| Healthcare Research Consultant /ID# 163096 | Tulsa | Oklahoma | 74135 | — |
| Northwest Gastroenterology Clinic /ID# 152528 | Portland | Oregon | 97210 | — |
| Guthrie Medical Group, PC /ID# 150533 | Sayre | Pennsylvania | 18840 | — |
| Penn State Health Colonnade /ID# 150267 | State College | Pennsylvania | 16803-2309 | — |
| Pharmacorp Clinical Trials /ID# 153363 | Charleston | South Carolina | 29412 | — |
| Gastroenterology Associates, P.A. of Greenville /ID# 150557 | Greenville | South Carolina | 29607 | — |
| Gastro One /ID# 151154 | Cordova | Tennessee | 38018 | — |
| Duplicate_East Tennessee Research Institute /ID# 203611 | Johnson City | Tennessee | 37604 | — |
| Quality Medical Research /ID# 203427 | Nashville | Tennessee | 37211 | — |
| Vanderbilt University Medical Center /ID# 153364 | Nashville | Tennessee | 37232-0011 | — |
| TX Clinical Research Institute /ID# 151528 | Arlington | Texas | 76012 | — |
| Inquest Clinical Research /ID# 164636 | Baytown | Texas | 77521-2415 | — |
| Texas Digestive Disease Consultants /ID# 209949 | Cedar Park | Texas | 78613-5028 | — |
| GI Alliance /ID# 209806 | Cedar Park | Texas | 78613 | — |
| Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 200771 | Dallas | Texas | 75246 | — |
| Digestive Health Associates of Texas (DHAT) Research Institute - Garland /ID# 151221 | Garland | Texas | 75044 | — |
| Vilo Research Group Inc /ID# 212626 | Houston | Texas | 77017-2337 | — |
| CliniCore International, LLC /ID# 152078 | Houston | Texas | 77027-6812 | — |
| Duplicate_Baylor College of Medicine - Baylor Medical Center /ID# 150538 | Houston | Texas | 77030-3411 | — |
| Centex Studies, Inc. - Houston /ID# 201217 | Houston | Texas | 77058 | — |
| GI Specialists of Houston /ID# 202337 | Houston | Texas | 77070-4347 | — |
| Duplicate_Caprock Gastro Research, LLC /ID# 215116 | Lubbock | Texas | 79424-3017 | — |
| Clinical Associates in Research Therapeutics of America, LLC /ID# 167954 | San Antonio | Texas | 78212 | — |
| Southern Star Research Institute, LLC /ID# 169397 | San Antonio | Texas | 78229-5390 | — |
| Carl R. Meisner Medical Clinic /ID# 171270 | Sugar Land | Texas | 77478 | — |
| Baylor Scott & White Center for Diagnostic Medicine /ID# 204777 | Temple | Texas | 76508 | — |
| Tyler Research Institute, LLC /ID# 169147 | Tyler | Texas | 75701 | — |
| Gastro Health & Nutrition - Victoria /ID# 167764 | Victoria | Texas | 77904 | — |
| HP Clinical Research /ID# 163941 | Bountiful | Utah | 84010 | — |
| Advanced Research Institute /ID# 162640 | Ogden | Utah | 84405 | — |
| Utah Gastroenternology - St. Mark's Office /ID# 163097 | Salt Lake City | Utah | 84124 | — |
| Duplicate_Velocity Clinical Research - Salt Lake City /ID# 163180 | West Jordan | Utah | 84088 | — |
| Ctr for Gastrointestinal Healt /ID# 153369 | Franklin | Virginia | 23851 | — |
| Texas Digestive Disease Consultants, PLLC dba GI Alliance /ID# 163630 | Bellevue | Washington | 98004 | — |
| Virginia Mason Hospital & Medical Center /ID# 153030 | Seattle | Washington | 98101 | — |
| The Polyclinic /ID# 165117 | Seattle | Washington | 98122-4201 | — |
| The Vancouver Clinic, INC. PS /ID# 162334 | Vancouver | Washington | 98664 | — |
| Aurora Medical Center - Grafto /ID# 151726 | Grafton | Wisconsin | 53024 | — |
| Wisconsin Center for Advanced Research /ID# 151845 | Milwaukee | Wisconsin | 53215 | — |
| Duplicate_Medical College of Wisconsin /ID# 151850 | Milwaukee | Wisconsin | 53226-3522 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 345 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03006068, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 12, 2026 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03006068 live on ClinicalTrials.gov.