ClinicalTrials.gov record
Medroxyprogesterone Acetate With or Without Entinostat Before Surgery in Treating Patients With Endometrioid Endometrial Cancer
ClinicalTrials.gov ID: NCT03018249
Public ClinicalTrials.gov record NCT03018249. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Surgical Window Pilot Investigation of the Relationship of Short Term Medroxyprogesterone Acetate (NSC #26386) Compared to Medroxyprogesterone Acetate Plus Entinostat (NSC #706995) on the Morphologic, Biochemical, and Molecular Changes in Primary Endometrioid Adenocarcinoma of the Uterine Corpus
Study identification
- NCT ID
- NCT03018249
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Early Phase 1
- Lead sponsor
- National Cancer Institute (NCI)
- NIH
- Enrollment
- 50 participants
Conditions and interventions
Conditions
Interventions
- Entinostat Drug
- Hysterectomy Procedure
- Laboratory Biomarker Analysis Other
- Medroxyprogesterone Acetate Drug
Drug · Procedure · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 10, 2017
- Primary completion
- Apr 17, 2018
- Completion
- Mar 11, 2021
- Last update posted
- Nov 15, 2021
2017 – 2021
United States locations
- U.S. sites
- 234
- U.S. states
- 33
- U.S. cities
- 161
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| CHI Saint Vincent Cancer Center Hot Springs | Hot Springs | Arkansas | 71913 | — |
| John Muir Medical Center-Concord Campus | Concord | California | 94520 | — |
| John Muir Medical Center-Walnut Creek | Walnut Creek | California | 94598 | — |
| Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado | 80012 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| Boulder Community Hospital | Boulder | Colorado | 80301 | — |
| Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado | 80304 | — |
| Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | 80907 | — |
| Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado | 80907 | — |
| Denver Health Medical Center | Denver | Colorado | 80204 | — |
| National Jewish Health-Main Campus | Denver | Colorado | 80206 | — |
| The Women's Imaging Center | Denver | Colorado | 80209 | — |
| Porter Adventist Hospital | Denver | Colorado | 80210 | — |
| Colorado Blood Cancer Institute | Denver | Colorado | 80218 | — |
| Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado | 80218 | — |
| Rocky Mountain Cancer Centers-Midtown | Denver | Colorado | 80218 | — |
| SCL Health Saint Joseph Hospital | Denver | Colorado | 80218 | — |
| Rocky Mountain Cancer Centers-Rose | Denver | Colorado | 80220 | — |
| Rose Medical Center | Denver | Colorado | 80220 | — |
| Mercy Medical Center | Durango | Colorado | 81301 | — |
| Southwest Oncology PC | Durango | Colorado | 81301 | — |
| Mountain Blue Cancer Care Center - Swedish | Englewood | Colorado | 80113 | — |
| Swedish Medical Center | Englewood | Colorado | 80113 | — |
| Mountain Blue Cancer Care Center | Golden | Colorado | 80401 | — |
| National Jewish Health-Western Hematology Oncology | Golden | Colorado | 80401 | — |
| North Colorado Medical Center | Greeley | Colorado | 80631 | — |
| Rocky Mountain Cancer Centers-Lakewood | Lakewood | Colorado | 80228 | — |
| Saint Anthony Hospital | Lakewood | Colorado | 80228 | — |
| Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado | 80120 | — |
| Littleton Adventist Hospital | Littleton | Colorado | 80122 | — |
| Rocky Mountain Cancer Centers-Sky Ridge | Lone Tree | Colorado | 80124 | — |
| Longmont United Hospital | Longmont | Colorado | 80501 | — |
| Rocky Mountain Cancer Centers-Longmont | Longmont | Colorado | 80501 | — |
| McKee Medical Center | Loveland | Colorado | 80539 | — |
| Parker Adventist Hospital | Parker | Colorado | 80138 | — |
| Rocky Mountain Cancer Centers-Parker | Parker | Colorado | 80138 | — |
| Saint Mary Corwin Medical Center | Pueblo | Colorado | 81004 | — |
| Rocky Mountain Cancer Centers - Pueblo | Pueblo | Colorado | 81008 | — |
| National Jewish Health-Northern Hematology Oncology | Thornton | Colorado | 80260 | — |
| Rocky Mountain Cancer Centers-Thornton | Thornton | Colorado | 80260 | — |
| SCL Health Lutheran Medical Center | Wheat Ridge | Colorado | 80033 | — |
| Beebe Medical Center | Lewes | Delaware | 19958 | — |
| Delaware Clinical and Laboratory Physicians PA | Newark | Delaware | 19713 | — |
| Helen F Graham Cancer Center | Newark | Delaware | 19713 | — |
| Medical Oncology Hematology Consultants PA | Newark | Delaware | 19713 | — |
| Christiana Care Health System-Christiana Hospital | Newark | Delaware | 19718 | — |
| Beebe Health Campus | Rehoboth Beach | Delaware | 19971 | — |
| TidalHealth Nanticoke / Allen Cancer Center | Seaford | Delaware | 19973 | — |
| Christiana Care Health System-Wilmington Hospital | Wilmington | Delaware | 19801 | — |
| Sacred Heart Hospital | Pensacola | Florida | 32504 | — |
| Kootenai Medical Center | Coeur d'Alene | Idaho | 83814 | — |
| Kootenai Cancer Center | Post Falls | Idaho | 83854 | — |
| Kootenai Cancer Clinic | Sandpoint | Idaho | 83864 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | — |
| Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | 60045 | — |
| Good Samaritan Regional Health Center | Mount Vernon | Illinois | 62864 | — |
| UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | 60451 | — |
| University of Chicago Medicine-Orland Park | Orland Park | Illinois | 60462 | — |
| Parkview Hospital Randallia | Fort Wayne | Indiana | 46805 | — |
| Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa | 50325 | — |
| Mercy Cancer Center-West Lakes | Clive | Iowa | 50325 | — |
| Alegent Health Mercy Hospital | Council Bluffs | Iowa | 51503 | — |
| Greater Regional Medical Center | Creston | Iowa | 50801 | — |
| Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa | 50314 | — |
| Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | — |
| University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | 52242 | — |
| Mercy Medical Center-West Lakes | West Des Moines | Iowa | 50266 | — |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas | 66205 | — |
| Flaget Memorial Hospital | Bardstown | Kentucky | 40004 | — |
| Commonwealth Cancer Center-Corbin | Corbin | Kentucky | 40701 | — |
| Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky | 40504 | — |
| Saint Joseph Hospital East | Lexington | Kentucky | 40509 | — |
| Saint Joseph London | London | Kentucky | 40741 | — |
| Jewish Hospital | Louisville | Kentucky | 40202 | — |
| Saints Mary and Elizabeth Hospital | Louisville | Kentucky | 40215 | — |
| Jewish Hospital Medical Center Northeast | Louisville | Kentucky | 40245 | — |
| Jewish Hospital Medical Center South | Shepherdsville | Kentucky | 40165 | — |
| Louisiana State University Health Science Center | New Orleans | Louisiana | 70112 | — |
| Ochsner Medical Center Jefferson | New Orleans | Louisiana | 70121 | — |
| Willis-Knighton Medical and Cancer Center | Shreveport | Louisiana | 71103 | — |
| Greater Baltimore Medical Center | Baltimore | Maryland | 21204 | — |
| Fairview Ridges Hospital | Burnsville | Minnesota | 55337 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| Unity Hospital | Fridley | Minnesota | 55432 | — |
| Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota | 55369 | — |
| Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | 55109 | — |
| Saint John's Hospital - Healtheast | Maplewood | Minnesota | 55109 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| Health Partners Inc | Minneapolis | Minnesota | 55454 | — |
| New Ulm Medical Center | New Ulm | Minnesota | 56073 | — |
| North Memorial Medical Health Center | Robbinsdale | Minnesota | 55422 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Saint Francis Regional Medical Center | Shakopee | Minnesota | 55379 | — |
| Lakeview Hospital | Stillwater | Minnesota | 55082 | — |
| Ridgeview Medical Center | Waconia | Minnesota | 55387 | — |
| Rice Memorial Hospital | Willmar | Minnesota | 56201 | — |
| Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | 55125 | — |
| Fairview Lakes Medical Center | Wyoming | Minnesota | 55092 | — |
| Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri | 63011 | — |
| Central Care Cancer Center - Bolivar | Bolivar | Missouri | 65613 | — |
| Cox Cancer Center Branson | Branson | Missouri | 65616 | — |
| Freeman Health System | Joplin | Missouri | 64804 | — |
| Mercy Hospital Joplin | Joplin | Missouri | 64804 | — |
| Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | 65401 | — |
| Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | 65401 | — |
| Heartland Regional Medical Center | Saint Joseph | Missouri | 64506 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| CoxHealth South Hospital | Springfield | Missouri | 65807 | — |
| Saint Louis Cancer and Breast Institute-South City | St Louis | Missouri | 63109 | — |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | — |
| Mercy Hospital Washington | Washington | Missouri | 63090 | — |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Bozeman Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Great Falls Clinic | Great Falls | Montana | 59405 | — |
| Saint Peter's Community Hospital | Helena | Montana | 59601 | — |
| Kalispell Regional Medical Center | Kalispell | Montana | 59901 | — |
| Community Medical Hospital | Missoula | Montana | 59804 | — |
| CHI Health Saint Francis | Grand Island | Nebraska | 68803 | — |
| Heartland Hematology and Oncology | Kearney | Nebraska | 68845 | — |
| CHI Health Good Samaritan | Kearney | Nebraska | 68847 | — |
| Saint Elizabeth Regional Medical Center | Lincoln | Nebraska | 68510 | — |
| Alegent Health Immanuel Medical Center | Omaha | Nebraska | 68122 | — |
| Hematology and Oncology Consultants PC | Omaha | Nebraska | 68122 | — |
| Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska | 68124 | — |
| Alegent Health Lakeside Hospital | Omaha | Nebraska | 68130 | — |
| Creighton University Medical Center | Omaha | Nebraska | 68131 | — |
| Midlands Community Hospital | Papillion | Nebraska | 68046 | — |
| Women's Cancer Center of Nevada | Las Vegas | Nevada | 89169 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87102 | — |
| Women's Cancer Care Associates LLC | Albany | New York | 12208 | — |
| State University of New York Downstate Medical Center | Brooklyn | New York | 11203 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Strecker Cancer Center-Belpre | Belpre | Ohio | 45714 | — |
| Adena Regional Medical Center | Chillicothe | Ohio | 45601 | — |
| Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio | 45220 | — |
| Bethesda North Hospital | Cincinnati | Ohio | 45242 | — |
| TriHealth Cancer Institute-Westside | Cincinnati | Ohio | 45247 | — |
| TriHealth Cancer Institute-Anderson | Cincinnati | Ohio | 45255 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Mount Carmel East Hospital | Columbus | Ohio | 43213 | — |
| Columbus Oncology and Hematology Associates Inc | Columbus | Ohio | 43214 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Grant Medical Center | Columbus | Ohio | 43215 | — |
| The Mark H Zangmeister Center | Columbus | Ohio | 43219 | — |
| Mount Carmel Health Center West | Columbus | Ohio | 43222 | — |
| Doctors Hospital | Columbus | Ohio | 43228 | — |
| Delaware Health Center-Grady Cancer Center | Delaware | Ohio | 43015 | — |
| Delaware Radiation Oncology | Delaware | Ohio | 43015 | — |
| Grady Memorial Hospital | Delaware | Ohio | 43015 | — |
| Fairfield Medical Center | Lancaster | Ohio | 43130 | — |
| OhioHealth Mansfield Hospital | Mansfield | Ohio | 44903 | — |
| Marietta Memorial Hospital | Marietta | Ohio | 45750 | — |
| OhioHealth Marion General Hospital | Marion | Ohio | 43302 | — |
| Knox Community Hospital | Mount Vernon | Ohio | 43050 | — |
| Licking Memorial Hospital | Newark | Ohio | 43055 | — |
| Newark Radiation Oncology | Newark | Ohio | 43055 | — |
| Southern Ohio Medical Center | Portsmouth | Ohio | 45662 | — |
| Saint Ann's Hospital | Westerville | Ohio | 43081 | — |
| Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | 43701 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | 73120 | — |
| Oklahoma Cancer Specialists and Research Institute-Tulsa | Tulsa | Oklahoma | 74146 | — |
| Abington Memorial Hospital | Abington | Pennsylvania | 19001 | — |
| UPMC-Heritage Valley Health System Beaver | Beaver | Pennsylvania | 15009 | — |
| Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | 19317 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | 15601 | — |
| Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania | 18201 | — |
| UPMC-Johnstown/John P. Murtha Regional Cancer Center | Johnstown | Pennsylvania | 15901 | — |
| Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | 17837 | — |
| Lewistown Hospital | Lewistown | Pennsylvania | 17044 | — |
| UPMC Cancer Center at UPMC McKeesport | McKeesport | Pennsylvania | 15132 | — |
| UPMC-Coraopolis/Heritage Valley Radiation Oncology | Moon Township | Pennsylvania | 15108 | — |
| UPMC-Magee Womens Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC-Presbyterian Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC-Saint Margaret | Pittsburgh | Pennsylvania | 15215 | — |
| University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC-Passavant Hospital | Pittsburgh | Pennsylvania | 15237 | — |
| UPMC-Saint Clair Hospital Cancer Center | Pittsburgh | Pennsylvania | 15243 | — |
| Geisinger Cancer Services-Pottsville | Pottsville | Pennsylvania | 17901 | — |
| Community Medical Center | Scranton | Pennsylvania | 18510 | — |
| Geisinger Medical Oncology-Selinsgrove | Selinsgrove | Pennsylvania | 17870 | — |
| UPMC Cancer Center at UPMC Northwest | Seneca | Pennsylvania | 16346 | — |
| Geisinger Medical Group | State College | Pennsylvania | 16801 | — |
| UPMC Uniontown Hospital Radiation Oncology | Uniontown | Pennsylvania | 15401 | — |
| UPMC Washington Hospital Radiation Oncology | Washington | Pennsylvania | 15301 | — |
| Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | 18711 | — |
| Women and Infants Hospital | Providence | Rhode Island | 02905 | — |
| Prisma Health Cancer Institute - Laurens | Clinton | South Carolina | 29325 | — |
| Prisma Health Cancer Institute - Easley | Easley | South Carolina | 29640 | — |
| Prisma Health Cancer Institute - Butternut | Greenville | South Carolina | 29605 | — |
| Prisma Health Cancer Institute - Faris | Greenville | South Carolina | 29605 | — |
| Prisma Health Greenville Memorial Hospital | Greenville | South Carolina | 29605 | — |
| Prisma Health Cancer Institute - Eastside | Greenville | South Carolina | 29615 | — |
| Prisma Health Cancer Institute - Greer | Greer | South Carolina | 29650 | — |
| Prisma Health Cancer Institute - Seneca | Seneca | South Carolina | 29672 | — |
| Prisma Health Cancer Institute - Spartanburg | Spartanburg | South Carolina | 29307 | — |
| Memorial Hospital | Chattanooga | Tennessee | 37404 | — |
| Vanderbilt-Ingram Cancer Center Cool Springs | Franklin | Tennessee | 37067 | — |
| Pulmonary Medicine Center of Chattanooga-Hixson | Hixson | Tennessee | 37343 | — |
| Vanderbilt Breast Center at One Hundred Oaks | Nashville | Tennessee | 37204 | — |
| Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| Memorial GYN Plus | Ooltewah | Tennessee | 37363 | — |
| Saint Joseph Regional Cancer Center | Bryan | Texas | 77802 | — |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22908 | — |
| Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington | 98310 | — |
| Harrison Medical Center | Bremerton | Washington | 98310 | — |
| Highline Medical Center-Main Campus | Burien | Washington | 98166 | — |
| Saint Elizabeth Hospital | Enumclaw | Washington | 98022 | — |
| Saint Francis Hospital | Federal Way | Washington | 98003 | — |
| Saint Clare Hospital | Lakewood | Washington | 98499 | — |
| Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington | 98370 | — |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| Franciscan Research Center-Northwest Medical Plaza | Tacoma | Washington | 98405 | — |
| Northwest Medical Specialties PLLC | Tacoma | Washington | 98405 | — |
| Cancer Center of Western Wisconsin | New Richmond | Wisconsin | 54017 | — |
| Cheyenne Regional Medical Center-West | Cheyenne | Wyoming | 82001 | — |
| Billings Clinic-Cody | Cody | Wyoming | 82414 | — |
| Welch Cancer Center | Sheridan | Wyoming | 82801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03018249, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 15, 2021 · Synced Jul 21, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03018249 live on ClinicalTrials.gov.