A Phase 2/3 Trial of the Efficacy and Safety of Bardoxolone Methyl in Patients With Alport Syndrome - CARDINAL
Public ClinicalTrials.gov record NCT03019185. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2/3 Trial of the Efficacy and Safety of Bardoxolone Methyl in Patients With Alport Syndrome
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This international, multi-center, Phase 2/3 trial will study the safety, tolerability, and efficacy of bardoxolone methyl in qualified patients with Alport syndrome. The Phase 2 portion of the trial will be open-label and enroll up to 30 patients. The Phase 3 portion of the trial will be double-blind, randomized, placebo-controlled and will enroll up to 180 patients.
Study identification
- NCT ID
- NCT03019185
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 187 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 12 Years to 60 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2, 2017 (Actual)
- Primary completion
- Oct 6, 2020 (Actual)
- Completion
- Oct 30, 2020 (Actual)
- Last update posted
- Jun 11, 2025
2017 – 2020
United States locations
- U.S. sites
- 38
- U.S. states
- 23
- U.S. cities
- 35
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Arizona Kidney Disease and Hypertension Research Services, PLLC | Phoenix | Arizona | 85308 | — |
| Scripps Clinic, Nephrology | La Jolla | California | 92037 | — |
| Academic Medical Research Institute | Los Angeles | California | 90022 | — |
| David Geffen School of Medicine at UCLA | Los Angeles | California | 90095 | — |
| General Clinical Research Center - Parnassus | San Francisco | California | 94143 | — |
| University of California San Francisco - Children's Renal Center | San Francisco | California | 94143 | — |
| Denver Nephrologists PC | Denver | Colorado | 80230 | — |
| South Florida Research Institute | Lauderdale Lakes | Florida | 33313 | — |
| Emory University School of Medicine and Children's Healthcare of Atlanta | Atlanta | Georgia | 30322 | — |
| Boise Kidney & Hypertension Institute | Caldwell | Idaho | 83605 | — |
| Boise Kidney & Hypertension Institute | Meridian | Idaho | 83642 | — |
| NorthShore University Health System | Evanston | Illinois | 60201 | — |
| Biolab Research, LLC | Rockville | Maryland | 20852 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| University of Minnesota - Division of Pediatric Nephrology | Minneapolis | Minnesota | 55454 | — |
| Children's Research Institute - The Children's Mercy Hospital | Kansas City | Missouri | 64108 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Hackensack Meridian School of Medicine | Hackensack | New Jersey | 07601 | — |
| Nephrology Associates, PC | Flushing | New York | 11355 | — |
| Columbia University Nephrology | New York | New York | 10032 | — |
| Duke University Medical Center | Durham | North Carolina | 27701 | — |
| Brookview Hills Research Associates, PLLC | Winston-Salem | North Carolina | 27103 | — |
| Akron Nephrology Associates | Akron | Ohio | 44302 | — |
| Akron Children's Hospital | Akron | Ohio | 44308 | — |
| University of Cincinnati | Cincinnati | Ohio | 45220 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Children's Hospital of Philadelphia (CHOP) | Philadelphia | Pennsylvania | 19104 | — |
| University of Pittsburgh School of Medicine - Division of Pediatric Nephrology | Pittsburgh | Pennsylvania | 15224 | — |
| The Warren Alpert Medical School of Brown University | Providence | Rhode Island | 02903 | — |
| South Carolina Nephrology & Hypertension Center, Inc | Orangeburg | South Carolina | 29118 | — |
| Renal Disease Research Institute | Dallas | Texas | 75235 | — |
| Southwest Houston Research | Houston | Texas | 77099 | — |
| Clinical Advancement Center | San Antonio | Texas | 78215 | — |
| University of Utah Health | Salt Lake City | Utah | 84132 | — |
| Advanced Clinical Research | West Jordan | Utah | 84088 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 25 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03019185, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 11, 2025 · Synced Oct 26, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03019185 live on ClinicalTrials.gov.