Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Insulin
Public ClinicalTrials.gov record NCT03021187. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Insulin. A 52-week, Randomised, Double-blind, Placebo-controlled Trial (PIONEER 8 - Insulin add-on)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This trial is conducted globally. The aim of the trial is to investigate the efficacy and safety of oral semaglutide versus placebo in subjects with Type 2 Diabetes Mellitus treated with insulin. All subjects should continue their pre-trial insulin therapy (basal, basal-bolus or premixed regimen including combinations of soluble insulins) throughout the trial. Subjects treated with metformin in addition to insulin treatment must continue their metformin treatment throughout the entire trial.
Study identification
- NCT ID
- NCT03021187
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 731 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 1, 2017
- Primary completion
- Jan 17, 2018
- Completion
- Aug 21, 2018
- Last update posted
- Mar 1, 2020
2017 – 2018
United States locations
- U.S. sites
- 50
- U.S. states
- 23
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Novo Nordisk Investigational Site | Anniston | Alabama | 36207 | — |
| Novo Nordisk Investigational Site | Birmingham | Alabama | 35211 | — |
| Novo Nordisk Investigational Site | Fountain Hills | Arizona | 85268 | — |
| Novo Nordisk Investigational Site | Glendale | Arizona | 85308 | — |
| Novo Nordisk Investigational Site | Mesa | Arizona | 85213 | — |
| Novo Nordisk Investigational Site | Phoenix | Arizona | 85037 | — |
| Novo Nordisk Investigational Site | Tucson | Arizona | 85723-0001 | — |
| Novo Nordisk Investigational Site | Tucson | Arizona | 85741 | — |
| Novo Nordisk Investigational Site | Anaheim | California | 92801 | — |
| Novo Nordisk Investigational Site | Fresno | California | 93720 | — |
| Novo Nordisk Investigational Site | Los Angeles | California | 90017 | — |
| Novo Nordisk Investigational Site | Los Angeles | California | 90057 | — |
| Novo Nordisk Investigational Site | Riverside | California | 92506 | — |
| Novo Nordisk Investigational Site | Van Nuys | California | 91405 | — |
| Novo Nordisk Investigational Site | Vista | California | 92083 | — |
| Novo Nordisk Investigational Site | Colorado Springs | Colorado | 80904 | — |
| Novo Nordisk Investigational Site | Denver | Colorado | 80246 | — |
| Novo Nordisk Investigational Site | Hialeah | Florida | 33016 | — |
| Novo Nordisk Investigational Site | Atlanta | Georgia | 30342 | — |
| Novo Nordisk Investigational Site | Chicago | Illinois | 60607 | — |
| Novo Nordisk Investigational Site | Franklin | Indiana | 46131 | — |
| Novo Nordisk Investigational Site | Lexington | Kentucky | 40503 | — |
| Novo Nordisk Investigational Site | Paducah | Kentucky | 42003 | — |
| Novo Nordisk Investigational Site | Metairie | Louisiana | 70002 | — |
| Novo Nordisk Investigational Site | Natchitoches | Louisiana | 71457-5881 | — |
| Novo Nordisk Investigational Site | Hyattsville | Maryland | 20782 | — |
| Novo Nordisk Investigational Site | Rockville | Maryland | 20852 | — |
| Novo Nordisk Investigational Site | Boston | Massachusetts | 02215 | — |
| Novo Nordisk Investigational Site | Troy | Michigan | 48098 | — |
| Novo Nordisk Investigational Site | Henderson | Nevada | 89052-2649 | — |
| Novo Nordisk Investigational Site | Las Vegas | Nevada | 89148 | — |
| Novo Nordisk Investigational Site | West Seneca | New York | 14224 | — |
| Novo Nordisk Investigational Site | Asheville | North Carolina | 28803 | — |
| Novo Nordisk Investigational Site | Chapel Hill | North Carolina | 27517 | — |
| Novo Nordisk Investigational Site | Cincinnati | Ohio | 45245 | — |
| Novo Nordisk Investigational Site | Dayton | Ohio | 45439 | — |
| Novo Nordisk Investigational Site | Beaver | Pennsylvania | 15009 | — |
| Novo Nordisk Investigational Site | Lansdale | Pennsylvania | 19446-1002 | — |
| Novo Nordisk Investigational Site | Summerville | South Carolina | 29485 | — |
| Novo Nordisk Investigational Site | Chattanooga | Tennessee | 37411 | — |
| Novo Nordisk Investigational Site | Kingsport | Tennessee | 37660-4652 | — |
| Novo Nordisk Investigational Site | Austin | Texas | 78731 | — |
| Novo Nordisk Investigational Site | Dallas | Texas | 75251 | — |
| Novo Nordisk Investigational Site | Dallas | Texas | 75390-9302 | — |
| Novo Nordisk Investigational Site | Houston | Texas | 77090 | — |
| Novo Nordisk Investigational Site | Mesquite | Texas | 75149 | — |
| Novo Nordisk Investigational Site | Midland | Texas | 79707 | — |
| Novo Nordisk Investigational Site | Round Rock | Texas | 78681 | — |
| Novo Nordisk Investigational Site | Murray | Utah | 84123 | — |
| Novo Nordisk Investigational Site | Winchester | Virginia | 22601 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 68 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03021187, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 1, 2020 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03021187 live on ClinicalTrials.gov.