EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)
Public ClinicalTrials.gov record NCT03057951. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III Randomised, Double-blind Trial to Evaluate Efficacy and Safety of Once Daily Empagliflozin 10 mg Compared to Placebo, in Patients With Chronic Heart Failure With Preserved Ejection Fraction (HFpEF)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a study in adults with chronic heart failure. People with chronic heart failure may need to be hospitalised for their condition. Some people with chronic heart failure may eventually die from their condition. The purpose of the study is to find out whether a medicine called empagliflozin lowers the chances of patients having to go to hospital for heart failure and whether it improves their survival. The study is open to patients with a type of chronic heart failure called chronic heart failure with preserved ejection fraction. Participants stay in the study until researchers have enough information about how effective empagliflozin is. It is expected that participants who enter at the very beginning of the enrolment period may be in the study for over 3 years, while participants who enter near the end of the enrolment period may be in the study for less than 2 years. The participants are put into 2 groups. It is decided by chance who gets into which group. One group gets empagliflozin tablets every day and the other group gets placebo tablets every day. Placebo tablets look like empagliflozin tablets but contain no medicine. Participants visit the doctors regularly. During these visits, the doctors collect information about the participant's health. The doctors want to know how many patients had to go to hospital because of heart failure or who died from cardiovascular disease.
Study identification
- NCT ID
- NCT03057951
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 5,988 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2, 2017 (Actual)
- Primary completion
- Apr 26, 2021 (Actual)
- Completion
- Apr 26, 2021 (Actual)
- Last update posted
- Jun 6, 2022
2017 – 2021
United States locations
- U.S. sites
- 135
- U.S. states
- 34
- U.S. cities
- 119
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group, LLC | Anniston | Alabama | 36207 | — |
| University of Alabama at Birmingham | Birmingham | Alabama | 35249 | — |
| Heart Center Research, LLC | Huntsville | Alabama | 35801 | — |
| University of California San Francisco | Fresno | California | 93701 | — |
| La Mesa Cardiac Center | La Mesa | California | 91942 | — |
| Purushotham, Akther & Roshan Kotha, MD Inc. | La Mesa | California | 91942 | — |
| Long Beach Center for Clinical Research | Long Beach | California | 90807 | — |
| VA Greater Los Angeles Healthcare System | Los Angeles | California | 90073 | — |
| Merced Vein and Vascular Center | Merced | California | 95340 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| University of California Irvine | Orange | California | 92865 | — |
| Covigilant Research, LLC | Riverside | California | 92506 | — |
| University of California San Francisco | San Francisco | California | 94143 | — |
| University of California | Torrance | California | 90502 | — |
| Orange County Research Center | Tustin | California | 92780 | — |
| Blue Coast Cardiology | Vista | California | 92083 | — |
| South Denver Cardiology Associates, PC | Littleton | Colorado | 80120 | — |
| Integrated Heart Care | Boca Raton | Florida | 33434 | — |
| Southeast Clinical Research, LLC | Chiefland | Florida | 32626 | — |
| Morton Plant Mease Health Care | Clearwater | Florida | 33756 | — |
| Accel Research Sites | DeLand | Florida | 32720 | — |
| Integrative Research Associates | Fort Lauderdale | Florida | 33312 | — |
| Nature Coast Clinical Research | Inverness | Florida | 34452 | — |
| East Coast Institute for Research, LLC | Jacksonville | Florida | 32216 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Elite Clinical Research | Miami | Florida | 33144 | — |
| Cardiovascular Research Center of South Florida | Miami | Florida | 33173 | — |
| Orlando Health Inc. | Orlando | Florida | 32806 | — |
| Peninsula Research, Inc. | Ormond Beach | Florida | 32174 | — |
| Clearwater Cardiovascular Consultants | Safety Harbor | Florida | 34695 | — |
| Sarasota Memorial Hospital | Sarasota | Florida | 34239 | — |
| University of South Florida | Tampa | Florida | 33606 | — |
| Advent Health Medical Group | Tampa | Florida | 33613 | — |
| Grady Clinical Research Center | Atlanta | Georgia | 30303 | — |
| Columbus Regional Research Institute | Columbus | Georgia | 31904 | — |
| Cardiovascular Group PC | Lawrenceville | Georgia | 30046 | — |
| Meridian Clinical Research, LLC | Savannah | Georgia | 31406 | — |
| Atlanta Heart Specialists, LLC | Tucker | Georgia | 30084 | — |
| Northwest Heart Clinical Research, LLC | Arlington Heights | Illinois | 60005 | — |
| Mount Sinai Hospital | Chicago | Illinois | 60608 | — |
| Advocate Health and Hospitals Corporation | Naperville | Illinois | 60540 | — |
| Captain James A. Lovell Federal Health Care Center | North Chicago | Illinois | 60064 | — |
| Rockford Cardiovascular Associates | Rockford | Illinois | 61107 | — |
| Midwest Cardiovascular Research and Education Foundation | Elkhart | Indiana | 46514 | — |
| St. Francis Medical Group-Indiana Heart Physicians, Inc | Indianapolis | Indiana | 46237 | — |
| Reid Hospital | Richmond | Indiana | 47374 | — |
| Beacon Medical Group Clinical Research | South Bend | Indiana | 46601 | — |
| Iowa Heart Center | Des Moines | Iowa | 50314 | — |
| Norton Heart Specialists | Louisville | Kentucky | 40202 | — |
| Research Integrity, LLC | Owensboro | Kentucky | 42303 | — |
| Grace Research, LLC | Bossier City | Louisiana | 71111 | — |
| Clinical Trials of America, LLC | Monroe | Louisiana | 71201 | — |
| LSU Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Maine Research Associates | Lewiston | Maine | 04240 | — |
| Anne Arundel Medical Center | Annapolis | Maryland | 21401 | — |
| Maryland Cardiovascular Specialists | Baltimore | Maryland | 21229 | — |
| MedStar Health Research Institute | Baltimore | Maryland | 21237 | — |
| Metropolitan Cardiovascular Consultants | Beltsville | Maryland | 20705 | — |
| MD Medical Research | Oxon Hill | Maryland | 20745 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| East Mountain Medical Associates, PC | Great Barrington | Massachusetts | 01230 | — |
| Alpena General Hospital | Alpena | Michigan | 49707 | — |
| McLaren Northern Michigan Hospital | Petoskey | Michigan | 49770 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| Jackson Heart Clinic, P.A. | Jackson | Mississippi | 39216 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| Saint Louis University | St Louis | Missouri | 63110 | — |
| St. Louis Center for Clinical Research | St Louis | Missouri | 63128 | — |
| St. Louis Heart and Vascular, P.C. | St Louis | Missouri | 63136 | — |
| Deaconess Billings Clinic Research Center | Billings | Montana | 59101 | — |
| Bozeman Health Clinical Research | Bozeman | Montana | 59718 | — |
| Nebraska Heart Institute | Grand Island | Nebraska | 68803 | — |
| CHI Health Midlands | Papillion | Nebraska | 68046 | — |
| Healthcare Partners LLC | Las Vegas | Nevada | 89109 | — |
| Palm Research Center | Las Vegas | Nevada | 89128 | — |
| Advanced Heart Care, LLC | Bridgewater | New Jersey | 08807 | — |
| Garden State Heart Care, PC | Manalapan | New Jersey | 07726 | — |
| Capital Cardiology Associates, PC | Albany | New York | 12211 | — |
| Trinity Medical WNY, PC | Cheektowaga | New York | 14227 | — |
| North Shore University Hospital | Manhasset | New York | 11030 | — |
| Long Island Cardiovascular Consultants | New Hyde Park | New York | 11042 | — |
| Mount Sinai - PRIME | New York | New York | 10025 | — |
| Harlem Cardiology | New York | New York | 10035 | — |
| Laurelton Heart Specialist, PC | Rosedale | New York | 11422 | — |
| Saratoga Clinical Research, LLC | Saratoga Springs | New York | 12866 | — |
| Northwell Health | Southampton | New York | 11968 | — |
| Stony Brook University Medical Center | Stony Brook | New York | 11794 | — |
| CHEAR Center LLC | The Bronx | New York | 10455 | — |
| Cardiac Care and Vascular Medicine, PLLC | The Bronx | New York | 10469 | — |
| Asheville Cardiology Associates | Asheville | North Carolina | 28803 | — |
| Kernodle Clinic West | Burlington | North Carolina | 27215 | — |
| The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599-5021 | — |
| Novant Health Heart and Vascular Institute | Charlotte | North Carolina | 28204 | — |
| Clinical Research of Gastonia | Gastonia | North Carolina | 28054 | — |
| Clinical Trials of America, Inc | Lenoir | North Carolina | 28645 | — |
| VA Northeast Ohio Healthcare System | Cleveland | Ohio | 44104-1702 | — |
| Rama Research LLC | Marion | Ohio | 43302 | — |
| South Oklahoma Heart Research Group | Oklahoma City | Oklahoma | 73135 | — |
| Doylestown Health Cardiology | Doylestown | Pennsylvania | 18901 | — |
| Lycoming Internal Medicine, Inc | Jersey Shore | Pennsylvania | 17740 | — |
| Richard M Kastelic and Associates | Johnstown | Pennsylvania | 15905 | — |
| York Hospital, WellSpan Health | York | Pennsylvania | 17403 | — |
| Lowcountry Center for Veterans Research | Charleston | South Carolina | 29401 | — |
| Palmetto Health | Columbia | South Carolina | 29203 | — |
| Clinical Research of Rock Hill | Rock Hill | South Carolina | 29732 | — |
| Palmetto Research Center, LLC | Spartanburg | South Carolina | 29302 | — |
| Sanford Research | Sioux Falls | South Dakota | 57104 | — |
| The Stern Cardiovascular Center | Germantown | Tennessee | 38138 | — |
| Apex Cardiology/ Research Associates of Jackson | Jackson | Tennessee | 38301 | — |
| Methodist University Hospital | Memphis | Tennessee | 38104 | — |
| Seton Heart Institute | Austin | Texas | 78705 | — |
| Baylor Heart and Vascular Hospital | Dallas | Texas | 75226 | — |
| Soltero Cardiovascular Research Center | Dallas | Texas | 75226 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390-8837 | — |
| University of North Texas Health Science Center | Fort Worth | Texas | 76107 | — |
| University of Texas Medical Branch at Galveston | Galveston | Texas | 77555 | — |
| Angiocardiac Care of Texas | Houston | Texas | 77025 | — |
| The Methodist Hospital | Houston | Texas | 77030 | — |
| Biopharma Informatic, Inc. Research Center | Houston | Texas | 77084 | — |
| Private Practice Leadership, LLC | Katy | Texas | 77493 | — |
| Baylor Scott and White Health | Plano | Texas | 75024 | — |
| Alpine Research Organization | Farmington | Utah | 84025 | — |
| Cardiac Health Management Network, P.C. | Chester | Virginia | 23836 | — |
| Cardiology Consultants of Danville, Inc | Danville | Virginia | 24541 | — |
| Carient Heart and Vascular | Manassas | Virginia | 20109 | — |
| Hunter Holmes McGuire VA Medical Center | Richmond | Virginia | 23249 | — |
| Medical College of Virginia Hospitals | Richmond | Virginia | 23298 | — |
| Roanoke Heart Institute PLC | Roanoke | Virginia | 24014 | — |
| Salem VA Medical Center | Salem | Virginia | 24153 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| Cardiology Associates of Bellin Health | Green Bay | Wisconsin | 54301 | — |
| Meriter Wisconsin Heart | Madison | Wisconsin | 53713 | — |
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | — |
| Aspirus Research Institute | Wausau | Wisconsin | 54401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 484 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03057951, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 6, 2022 · Synced Oct 16, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03057951 live on ClinicalTrials.gov.