ClinicalTrials.gov record
EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)
ClinicalTrials.gov ID: NCT03057977
Public ClinicalTrials.gov record NCT03057977. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III Randomised, Double-blind Trial to Evaluate Efficacy and Safety of Once Daily Empagliflozin 10 mg Compared to Placebo, in Patients With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The aim of the study is to investigate the safety and efficacy of empagliflozin versus placebo on top of guideline-directed medical therapy in patients with heart failure with reduced ejection fraction.
Study identification
- NCT ID
- NCT03057977
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 3,730 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 6, 2017 (Actual)
- Primary completion
- May 1, 2020 (Actual)
- Completion
- May 28, 2020 (Actual)
- Last update posted
- May 18, 2021
2017 – 2020
United States locations
- U.S. sites
- 92
- U.S. states
- 26
- U.S. cities
- 84
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| La Mesa Cardiac Center | La Mesa | California | 91942 | — |
| Long Beach Center for Clinical Research | Long Beach | California | 90807 | — |
| VA Greater Los Angeles Healthcare System | Los Angeles | California | 90073 | — |
| Merced Vein and Vascular Center | Merced | California | 95340 | — |
| University of California Irvine | Orange | California | 92865 | — |
| Covigilant Research, LLC | Riverside | California | 92506 | — |
| University of California | Torrance | California | 90502 | — |
| Orange County Research Center | Tustin | California | 92780 | — |
| Blue Coast Cardiology | Vista | California | 92083 | — |
| South Denver Cardiology Associates, PC | Littleton | Colorado | 80120 | — |
| Integrated Heart Care | Boca Raton | Florida | 33434 | — |
| Morton Plant Mease Health Care | Clearwater | Florida | 33756 | — |
| Nature Coast Clinical Research | Crystal River | Florida | 34429 | — |
| Avail Clinical Research, LLC | DeLand | Florida | 32720 | — |
| Holy Cross Hospital | Fort Lauderdale | Florida | 33308 | — |
| Integrative Research Associates | Fort Lauderdale | Florida | 33312 | — |
| Nature Coast Clinical Research | Inverness | Florida | 34452 | — |
| East Coast Institute for Research, LLC | Jacksonville | Florida | 32216 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Cardiovascular Research Center of South Florida | Miami | Florida | 33173 | — |
| Peninsula Research, Inc. | Ormond Beach | Florida | 32174 | — |
| Cardiology Consultants, Inc | Pensacola | Florida | 32501 | — |
| Sarasota Memorial Hospital | Sarasota | Florida | 34239 | — |
| Grady Clinical Research Center | Atlanta | Georgia | 30303 | — |
| Augusta University | Augusta | Georgia | 30912 | — |
| Columbus Regional Research Institute | Columbus | Georgia | 31904 | — |
| Cardiovascular Group PC | Lawrenceville | Georgia | 30046 | — |
| Meridian Clinical Research, LLC | Savannah | Georgia | 31406 | — |
| Northwest Heart Clinical Research, LLC | Arlington Heights | Illinois | 60005 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Captain James A. Lovell Federal Health Care Center | North Chicago | Illinois | 60064 | — |
| Rockford Cardiovascular Associates | Rockford | Illinois | 61107 | — |
| Midwest Cardiovascular Research and Education Foundation | Elkhart | Indiana | 46514 | — |
| St. Francis Medical Group-Indiana Heart Physicians, Inc | Indianapolis | Indiana | 46237 | — |
| Reid Hospital | Richmond | Indiana | 47374 | — |
| Beacon Medical Group Clinical Research | South Bend | Indiana | 46601 | — |
| Research Integrity, LLC | Owensboro | Kentucky | 42303 | — |
| Cambridge Medical Trials | Alexandria | Louisiana | 71301 | — |
| Louisiana Heart Center | Covington | Louisiana | 70433 | — |
| Clinical Trials of America, LLC | Monroe | Louisiana | 71201 | — |
| Tulane University Hospital and Clinic | New Orleans | Louisiana | 70112 | — |
| Anne Arundel Medical Center | Annapolis | Maryland | 21401 | — |
| Johns Hopkins University Hospital School of Medicine | Baltimore | Maryland | 21205 | — |
| MedStar Health Research Institute | Baltimore | Maryland | 21237 | — |
| Metropolitan Cardiovascular Consultants | Beltsville | Maryland | 20705 | — |
| Spectrum Clinical Research | Towson | Maryland | 21204 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| East Mountain Medical Associates, PC | Great Barrington | Massachusetts | 01230 | — |
| Alpena General Hospital | Alpena | Michigan | 49707 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| Saint Louis University | St Louis | Missouri | 63110 | — |
| SLHV | St Louis | Missouri | 63136 | — |
| Palm Research Center | Las Vegas | Nevada | 89148 | — |
| Advanced Heart Care, LLC | Bridgewater | New Jersey | 08807 | — |
| Trinity Medical WNY, PC | Cheektowaga | New York | 14227 | — |
| Northwell Health | Great Neck | New York | 11021 | — |
| Mount Sinai School of Medicine | Lake Success | New York | 11041 | — |
| St. Luke's Roosevelt Hospital | New York | New York | 10025 | — |
| Harlem Cardiology | New York | New York | 10035 | — |
| Stony Brook University Medical Center | Stony Brook | New York | 11794 | — |
| Cardiac Care and Vascular Medicine, PLLC | The Bronx | New York | 10469 | — |
| Asheville Cardiology Associates | Asheville | North Carolina | 28803 | — |
| Kernodle Clinic West | Burlington | North Carolina | 27215 | — |
| The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599-5021 | — |
| Novant Health Heart and Vascular Institute | Charlotte | North Carolina | 28204 | — |
| Duke University Medical Center | Durham | North Carolina | 27609 | — |
| Clinical Research of Gastonia | Gastonia | North Carolina | 28054 | — |
| Clinical Trials of America, Inc | Lenoir | North Carolina | 28645 | — |
| Rama Research LLC | Marion | Ohio | 43302 | — |
| University of Toledo | Toledo | Ohio | 43614 | — |
| South Oklahoma Heart Research Group | Oklahoma City | Oklahoma | 73135 | — |
| Doylestown Health Cardiology | Doylestown | Pennsylvania | 18901 | — |
| York Hospital, WellSpan Health | York | Pennsylvania | 17403 | — |
| AnMed Health Clinical Research | Anderson | South Carolina | 29621 | — |
| Ralph H. Johnson VA Medical Center | Charleston | South Carolina | 29401 | — |
| Palmetto Health | Columbia | South Carolina | 29203 | — |
| William Jennings Bryan Dorn VA Medical Center | Columbia | South Carolina | 29209 | — |
| Clinical Research of Rock Hill | Rock Hill | South Carolina | 29732 | — |
| Palmetto Research Center, LLC | Spartanburg | South Carolina | 29302 | — |
| Methodist University Hospital | Memphis | Tennessee | 38104 | — |
| Baylor Heart and Vascular Hospital | Dallas | Texas | 75226 | — |
| Soltero Cardiovascular Research Center | Dallas | Texas | 75226 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390-8837 | — |
| University of North Texas Health Science Center | Fort Worth | Texas | 76107 | — |
| The Methodist Hospital | Houston | Texas | 77030 | — |
| The Heart Hospital | Plano | Texas | 75093 | — |
| Alpine Research Organization | Farmington | Utah | 84025 | — |
| Cardiac Health Management Network, P.C. | Chester | Virginia | 23836 | — |
| Hunter Holmes McGuire VA Medical Center | Richmond | Virginia | 23249 | — |
| Roanoke Heart Institute PLC | Roanoke | Virginia | 24014 | — |
| Salem VA Medical Center | Salem | Virginia | 24153 | — |
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 428 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03057977, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 18, 2021 · Synced Oct 31, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03057977 live on ClinicalTrials.gov.