ClinicalTrials.gov record
Pemafibrate to Reduce Cardiovascular OutcoMes by Reducing Triglycerides IN patiENts With diabeTes (PROMINENT)
ClinicalTrials.gov ID: NCT03071692
Public ClinicalTrials.gov record NCT03071692. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of the study is to determine whether pemafibrate administered twice daily will delay the time to first occurrence of any component of the clinical composite endpoint of: * nonfatal Myocardial Infarction (MI) * nonfatal ischemic stroke * coronary revascularization; or * Cardio Vascular (CV) death.
Study identification
- NCT ID
- NCT03071692
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 10,544 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 22, 2017
- Primary completion
- Jul 26, 2022
- Completion
- Jul 26, 2022
- Last update posted
- Sep 24, 2025
2017 – 2022
United States locations
- U.S. sites
- 242
- U.S. states
- 42
- U.S. cities
- 195
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Synexus Clinical Research US, Inc. | Birmingham | Alabama | 35211 | — |
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| VA Medical Center - Birmingham | Birmingham | Alabama | 35233 | — |
| Alabama Clinical Therapeutics, LLC | Birmingham | Alabama | 35235 | — |
| Fundamental Research, LLC | Gulf Shores | Alabama | 36542 | — |
| Mobile Heart Specialists, PC | Mobile | Alabama | 36608 | — |
| Terence T. Hart, MD | Tuscumbia | Alabama | 35674 | — |
| Synexus Clinical Research US, Inc. | Chandler | Arizona | 85224-6279 | — |
| Synexus Clinical Research US, Inc. | Mesa | Arizona | 85206 | — |
| Arizona Arthritis & Rheumatology Research, PLLC | Peoria | Arizona | 85381 | — |
| Phoenix Veterans Adminstration Health Care System | Phoenix | Arizona | 85012 | — |
| Synexus Clinical Research US, Inc. | Phoenix | Arizona | 85050 | — |
| Clinical Research Institute of Arizona, LLC | Surprise | Arizona | 85374 | — |
| Synexus Clinical Research US, Inc. | Tucson | Arizona | 85712 | — |
| Eclipse Clinical Research | Tucson | Arizona | 85745 | — |
| Central Arkansas Veterans Healthcare System | Little Rock | Arkansas | 72205 | — |
| Clinical Research Alliance, Inc | Alhambra | California | 91801 | — |
| Aurora Care Clinic | Costa Mesa | California | 92627 | — |
| AMCR Institute, Inc. | Escondido | California | 92025 | — |
| National Institute of Clinical Research | Huntington Beach | California | 92648-1717 | — |
| VA Loma Linda Healthcare System | Loma Linda | California | 92354 | — |
| VA Long Beach Healthcare System | Long Beach | California | 90822 | — |
| Eastside Clinical Research Associates | Los Angeles | California | 90022 | — |
| VA Greater Los Angeles Healthcare System | Los Angeles | California | 90073 | — |
| Richard S. Cherlin, MD | Los Gatos | California | 95032 | — |
| Northridge Clinical Research Inc. | Northridge | California | 91324 | — |
| Palo Alto Division | Palo Alto | California | 94304 | — |
| Huntington Hospital - Research Department | Pasadena | California | 91105 | — |
| Rancho Cucamonga Clinical Research | Rancho Cucamonga | California | 91730 | — |
| MD Strategies Research Centers | San Diego | California | 92119 | — |
| Alex Harrison, MD Inc. | Santa Maria | California | 93454 | — |
| Santa Rosa Cardiology Medical Group, Inc. | Santa Rosa | California | 95404 | — |
| Blue Coast Cardiology | Vista | California | 92083 | — |
| Lynn Institute of Denver | Aurora | Colorado | 80012 | — |
| New West Physicians, PC | Golden | Colorado | 80401 | — |
| Southwest Family Medicine | Littleton | Colorado | 80127 | — |
| Chase Medical Research, LLC | Waterbury | Connecticut | 06708 | — |
| VA Connecticut Healthcare Sys | West Haven | Connecticut | 06516-2770 | — |
| Cardiology Physicians, PA | Newark | Delaware | 19713 | — |
| Bay Pines VA Healthcare System | Bay Pines | Florida | 33744 | — |
| Meridien Research | Bradenton | Florida | 34201 | — |
| Clinical Research Of Brandon, LLC | Brandon | Florida | 33511 | — |
| Clearwater Cardiovascular Consultants | Clearwater | Florida | 33756 | — |
| Daytona Heart Group | Daytona Beach | Florida | 32114 | — |
| Cohen Medical Research Associates, LLC | Delray Beach | Florida | 33446 | — |
| Malcom Randall VA Medical Center | Gainesville | Florida | 32608 | — |
| Pines Clinical Research, Inc. | Hollywood | Florida | 33024 | — |
| Homestead Cardiac & Vein Center | Homestead | Florida | 33030 | — |
| Westside Center for Clinical Research | Jacksonville | Florida | 32205 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Health Awareness, Inc. | Jupiter | Florida | 33458 | — |
| Meridien Research | Lakeland | Florida | 33805 | — |
| Clearwater Cardiovascular & Interventional Consultants | Largo | Florida | 33777 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Advanced Medical Research Institute | Miami | Florida | 33174 | — |
| Ocala Research Institute, Inc. | Ocala | Florida | 34471 | — |
| Morgan Medical Management & Consultants Inc. | Ocala | Florida | 34474 | — |
| Endocrine Associates of Florida | Ocoee | Florida | 34761 | — |
| Research Physicians Network Alliance | Orlando | Florida | 32803 | — |
| Andres Patron, D.O., P.A | Pembroke Pines | Florida | 33026 | — |
| DBC Research, Corp | Pembroke Pines | Florida | 33029 | — |
| Langhorne Cardiology Consultants, Inc. | Pensacola | Florida | 32501 | — |
| Clearwater Cardiovascular Consultants | Safety Harbor | Florida | 34695 | — |
| Professional Health Care of Pinellas | St. Petersburg | Florida | 33713 | — |
| James A. Haley VA Medical Center | Tampa | Florida | 33612 | — |
| Clinical Research of Central Florida | Winter Haven | Florida | 33880 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| Atlanta Heart Specialists, LLC | Cumming | Georgia | 30041 | — |
| VA Medical Center - Atlanta | Decatur | Georgia | 30033 | — |
| Alta Pharmaceutical Research Center, Inc. | Dunwoody | Georgia | 30338 | — |
| Atlanta Heart Specialists, LLC | Tucker | Georgia | 30084 | — |
| Christie Clinic, LLC | Champaign | Illinois | 61822 | — |
| Apex Medical Research, AMR, Inc. | Chicago | Illinois | 60607 | — |
| Clinical Investigation Specialists, Inc. | Gurnee | Illinois | 60031 | — |
| Edward Hines Jr. VA Hospital | Hines | Illinois | 60141 | — |
| Advocate Health and Hospitals Corp | Normal | Illinois | 61761 | — |
| Captain James A. Lovell Federal Health Care Center | North Chicago | Illinois | 60064 | — |
| Specialty Physicians of Illinois | Olympia Fields | Illinois | 60461 | — |
| Community Hospital of Anderson and Madison County, Inc. | Anderson | Indiana | 46011 | — |
| Synexus Clinical Research US, Inc. | Evansville | Indiana | 47714 | — |
| Deaconess Clinic | Evansville | Indiana | 47725 | — |
| VA Medical Center - Indianapolis | Indianapolis | Indiana | 46202 | — |
| Cardiovascular Research of Northwest Indiana, LLC | Munster | Indiana | 46321 | — |
| Buynak Clinical Research | Valparaiso | Indiana | 46383 | — |
| West Broadway Clinic | Council Bluffs | Iowa | 51501 | — |
| Iowa Diabetes and Endocrinology Research Center, PLC | Des Moines | Iowa | 50314 | — |
| The Iowa Clinic, PC | West Des Moines | Iowa | 50266 | — |
| University of Kansas Medical Center Research Institute, Inc. | Kansas City | Kansas | 66160 | — |
| VA Eastern Kansas Health Care | Leavenworth | Kansas | 66048 | — |
| The Research Group of Lexington, LLC | Lexington | Kentucky | 40503 | — |
| Robley Rex VA Medical Center | Louisville | Kentucky | 40206 | — |
| Cambridge Medical Trials | Alexandria | Louisiana | 71301 | — |
| Cardiovascular Associates Research, LLC | Covington | Louisiana | 70433 | — |
| Centex Studies Inc. | Lake Charles | Louisiana | 70601 | — |
| Overton Brooks VA Medical Center | Shreveport | Louisiana | 71101 | — |
| Southern Maine Health Care | Biddeford | Maine | 04005 | — |
| Baltimore VA medical centre | Baltimore | Maryland | 21201 | — |
| University of Maryland School of Medicine | Baltimore | Maryland | 21201 | — |
| Maryland Cardiovascular Specialists | Baltimore | Maryland | 21229 | — |
| Medstar Health Research Institute | Hyattsville | Maryland | 20782 | — |
| Delmarva Heart Research Foundation, Inc. | Salisbury | Maryland | 21804 | — |
| Joslin Diabetes Center | Boston | Massachusetts | 02215 | — |
| Pentucket Medical Associates | Haverhill | Massachusetts | 01830 | — |
| South Shore Internal Medicine Associates | Milton | Massachusetts | 02186 | — |
| University of Michigan | Ann Arbor | Michigan | 48105 | — |
| Veterans Affairs Ann Arbor Healthcare System | Ann Arbor | Michigan | 48105 | — |
| Northern Pines Health Center | Buckley | Michigan | 49620 | — |
| Cadillac Clinical Research, LLC | Cadillac | Michigan | 49601 | — |
| AA MRC LLC Ahmed Arif Medical Research Center | Flint | Michigan | 48504 | — |
| Sparrow Clinical Research Institute | Lansing | Michigan | 48912 | — |
| Covenant Medical Center, Inc. | Saginaw | Michigan | 48602 | — |
| Minneapolis Heart Institute Foundation | Minneapolis | Minnesota | 55407 | — |
| Synexus Clinical Research US, Inc. | Richfield | Minnesota | 55432 | — |
| CentraCare Heart & Vascular | Saint Cloud | Minnesota | 56303-1900 | — |
| HealthEast Medical Research Institute | Saint Paul | Minnesota | 55102 | — |
| GV Montgomery VA Medical Center | Jackson | Mississippi | 39216 | — |
| Kansas City VA Medical Center | Kansas City | Missouri | 64128 | — |
| Synexus Clinical Research US, Inc. | St Louis | Missouri | 63141 | — |
| Kalispell Regional Medical Center dba Glacier View Research Institute | Kalispell | Montana | 59901 | — |
| VA Nebraska-Western Iowa Health Care System | Omaha | Nebraska | 68105 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198-4120 | — |
| Synexus Clinical Research US, Inc. | Papillion | Nebraska | 68046 | — |
| Synexus Clinical Research US, Inc. | Henderson | Nevada | 89052 | — |
| Red Rock Clinical Research LLC | Las Vegas | Nevada | 89146 | — |
| VA Sierra Nevada Health Care System | Reno | Nevada | 89502 | — |
| Southern New Hampshire Diabetes and Endocrinology | Nashua | New Hampshire | 03063 | — |
| Monmouth Cardiology Associates | Eatontown | New Jersey | 07724 | — |
| NJ Heart | Linden | New Jersey | 07036 | — |
| The Valley Hospital | Ridgewood | New Jersey | 07450 | — |
| Raymond G. Murphy VA Medical Center | Albuquerque | New Mexico | 87108 | — |
| Endocrine Group, L.L.P. | Albany | New York | 12206 | — |
| Stratton Veterans Affairs Medical Center - Albany | Albany | New York | 12208 | — |
| Buffalo VA Medical Center | Buffalo | New York | 14215 | — |
| Winthrop Cardiology Associates | Mineola | New York | 11501 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| VA Medical Center - Syracuse | Syracuse | New York | 13210 | — |
| Randolph Medical Associates | Asheboro | North Carolina | 27203 | — |
| OnSite Clinical Solutions, LLC | Asheville | North Carolina | 28801 | — |
| Kernodle Clinic, Inc., Dept. of the Private Diagnostic Clinic, PLLC | Burlington | North Carolina | 27215 | — |
| Cary Research Group, LLC | Cary | North Carolina | 27518 | — |
| PMG Research of Cary, LLC | Cary | North Carolina | 27518 | — |
| Novant Health - Heart and Vascular Institute | Charlotte | North Carolina | 28204 | — |
| The Presbyterian Hospital | Charlotte | North Carolina | 28204 | — |
| Focus Clinical Research Solutions | Charlotte | North Carolina | 28277 | — |
| Medication Management, LLC | Greensboro | North Carolina | 27408 | — |
| Triad Clinical Trials, LLC | Greensboro | North Carolina | 27410 | — |
| Clinical Trials of America-NC, LLC | Hickory | North Carolina | 28601 | — |
| PMG Research of Hickory, LLC | Hickory | North Carolina | 28601 | — |
| Research Institute of the Carolinas, PLC | Mooresville | North Carolina | 28117 | — |
| Diabetes and Endocrinology Consultants | Morehead City | North Carolina | 28557 | — |
| Pinehurst Medical Clinic Inc | Pinehurst | North Carolina | 28374 | — |
| PMG Research of Raleigh, LLC | Raleigh | North Carolina | 27609 | — |
| PMG Research of Rocky Mount, LLC | Rocky Mount | North Carolina | 27804 | — |
| PMG Research of Salisbury, LLC | Salisbury | North Carolina | 28144 | — |
| Carolina Research Center, Inc. | Shelby | North Carolina | 28150-3803 | — |
| Synexus Clinical Research US, Inc. | Akron | Ohio | 44311 | — |
| OhioHealth Heart & Vascular Physicians (Heartcare, Inc.) - Athens | Athens | Ohio | 45701 | — |
| Aultman Hospital | Canton | Ohio | 44710 | — |
| Hometown Urgent Care & Occupational Health | Cincinnati | Ohio | 45215 | — |
| Cincinnati Veterans Affairs Medical Center | Cincinnati | Ohio | 45267 | — |
| Louis Stokes Cleveland Dept of VA Medical Center | Cleveland | Ohio | 44106 | — |
| Prestige Clinical Research Center | Franklin | Ohio | 45005 | — |
| Craig S Thompson MD LLC | Marion | Ohio | 43302 | — |
| Intend Research | Norman | Oklahoma | 73069 | — |
| Lynn Institute of Norman | Norman | Oklahoma | 73069 | — |
| Oklahoma City Clinic - Central | Oklahoma City | Oklahoma | 73104 | — |
| South Oklahoma Heart Research Group | Oklahoma City | Oklahoma | 73135 | — |
| Heart Clinic of Southern Oregon | Medford | Oregon | 97504 | — |
| Chambersburg Hospital | Chambersburg | Pennsylvania | 17201 | — |
| AMH Feasterville Family Health Care Center | Feasterville | Pennsylvania | 19053 | — |
| Family Medical Associates | Levittown | Pennsylvania | 19056 | — |
| VA Pittsburgh Healthcare System | Pittsburgh | Pennsylvania | 15240 | — |
| Preferred Primary Care Physicians | Pittsburgh | Pennsylvania | 15317 | — |
| Fay West Family Practice | Scottdale | Pennsylvania | 15683 | — |
| Montgomery Medical Inc. | Smithfield | Pennsylvania | 15478 | — |
| Partners in Clinical Research | Cumberland | Rhode Island | 02864 | — |
| Ocean State Clinical Research Partners | Lincoln | Rhode Island | 02865 | — |
| Providence Veteran Administration Medical Center | Providence | Rhode Island | 02908 | — |
| Synexus Clinical Research US, Inc. | Anderson | South Carolina | 29621-2062 | — |
| Ralph H. Johnson VA Medical Center | Charleston | South Carolina | 29401 | — |
| Mountain View Clinical Research, Inc. | Greer | South Carolina | 29651 | — |
| Main Street Physician's Care - Waterway | Little River | South Carolina | 29566 | — |
| Family Medicine of Sayebrook | Myrtle Beach | South Carolina | 29588 | — |
| Piedmont Research Partners | Old Point Station | South Carolina | 29707 | — |
| Palmetto Research Center, LLC | Spartanburg | South Carolina | 29302 | — |
| Palmetto Clinical Research | Summerville | South Carolina | 29485 | — |
| PMG Research of Bristol, LLC | Bristol | Tennessee | 37620 | — |
| Chattanooga Medical Research, LLC | Chattanooga | Tennessee | 37404 | — |
| Chattanooga Research and Medicine (CHARM) | Chattanooga | Tennessee | 37404 | — |
| University Diabetes & Endocrine Consultants | Chattanooga | Tennessee | 37411 | — |
| WR-ClinSearch, LLC | Chattanooga | Tennessee | 37421 | — |
| Holston Medical Group, P.C. | Kingsport | Tennessee | 37660 | — |
| Metro Knoxville HMA, LLC | Knoxville | Tennessee | 37934 | — |
| VA Medical Center - Memphis | Memphis | Tennessee | 38104 | — |
| Tennessee Valley Healthcare System | Nashville | Tennessee | 37232 | — |
| Central Texas Clinical Research, LLC | Austin | Texas | 78705 | — |
| Protenium Clinical Research | Dallas | Texas | 75208 | — |
| VA Medical Center - Dallas | Dallas | Texas | 75216 | — |
| North Texas Endocrine Center | Dallas | Texas | 75231 | — |
| Research Institute of Dallas, P.A. | Dallas | Texas | 75231 | — |
| Synexus Clinical Research US, Inc. | Dallas | Texas | 75234 | — |
| Doctors Hospital at Renaissance | Edinburg | Texas | 78539 | — |
| Texas Health Research & Education Institute | Fort Worth | Texas | 76104 | — |
| Texas Health Physicians Group | Fort Worth | Texas | 76107 | — |
| University of North Texas Health Science Center | Fort Worth | Texas | 76107 | — |
| Diabetes and Thyroid Center of Fort Worth | Fort Worth | Texas | 76132 | — |
| Rockwood Medical Clinic | Fort Worth | Texas | 76164 | — |
| East Texas Cardiology PA | Houston | Texas | 77002 | — |
| Endocrine Associates, LLC | Houston | Texas | 77004 | — |
| Heights Doctors Clinic | Houston | Texas | 77008 | — |
| Associates in Medicine | Houston | Texas | 77027 | — |
| Michael E. DeBakey VA Medical Center | Houston | Texas | 77030 | — |
| Southwest Clinical Trials | Houston | Texas | 77081 | — |
| Protenium Clinical Research | Hurst | Texas | 76054 | — |
| Houston Methodist Research Institute - CCAT Pearland | Pearland | Texas | 77584 | — |
| Clinical Investigations of Texas | Plano | Texas | 75075 | — |
| Consano Clinical Research, LLC | San Antonio | Texas | 78205 | — |
| Sant Antonio Premiere Internal Medicine | San Antonio | Texas | 78220 | — |
| Briggs Clinical Research, LLC. | San Antonio | Texas | 78224 | — |
| Schnitzler Cardiovascular Consultants (SCC), PLLC | San Antonio | Texas | 78229-3271 | — |
| Bandera Family Healthcare Research LLC | San Antonio | Texas | 78249 | — |
| Northeast Clinical Research of San Antonio | Schertz | Texas | 78154 | — |
| Spring Family Practice Associates | Spring | Texas | 77379 | — |
| Northwest Houston Heart Center | Tomball | Texas | 77375 | — |
| Victoria Heart & Vascular Center | Victoria | Texas | 77901 | — |
| Hillcrest Family Health Clinics | Waco | Texas | 76710 | — |
| Utah Cardiology, P.C. (Davis) | Farmington | Utah | 84025 | — |
| VA Medical Center | White River Junction | Vermont | 05055 | — |
| Burke Internal Medicine & Research | Burke | Virginia | 22015 | — |
| Virginia Endocrinology Research | Chesapeake | Virginia | 23321 | — |
| Carient Heart and Vascular | Manassas | Virginia | 20109 | — |
| Clinical Research Partners, LLC | Richmond | Virginia | 23220 | — |
| McGuire DVA Medical Center | Richmond | Virginia | 23249 | — |
| Roanoke Heart Institute | Roanoke | Virginia | 24014 | — |
| Suffolk Multispecialty Research | Suffolk | Virginia | 23435 | — |
| Corporation Lane Internal Medicine | Virginia Beach | Virginia | 23462 | — |
| Cardiology Associates of Bellin Health | Green Bay | Wisconsin | 54301 | — |
| Clinical Investigation Specialists Inc | Kenosha | Wisconsin | 53144 | — |
| Mayo Clinic Health System | La Crosse | Wisconsin | 54601 | — |
| Meriter Medical Group, Inc. | Madison | Wisconsin | 53713 | — |
| Zablocki VA Medical Center | Milwaukee | Wisconsin | 53295 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 646 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03071692, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 24, 2025 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03071692 live on ClinicalTrials.gov.