ClinicalTrials.gov record
Clostridium Difficile Vaccine Efficacy Trial
ClinicalTrials.gov ID: NCT03090191
Public ClinicalTrials.gov record NCT03090191. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 3, PLACEBO-CONTROLLED, RANDOMIZED, OBSERVER-BLINDED STUDY TO EVALUATE THE EFFICACY, SAFETY, AND TOLERABILITY OF A CLOSTRIDIUM DIFFICILE VACCINE IN ADULTS 50 YEARS OF AGE AND OLDER
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The Clover trial is evaluating an investigational vaccine that may help to prevent Clostridium difficile infection. Participants in the study are adults 50 years of age and older, who are at risk of developing Clostridium difficile infection. The study will assess whether the vaccine prevents the disease, and whether it is safe and well tolerated. Each subject will receive 3 doses of Clostridium difficile vaccine or placebo and be followed for up to 3 years after vaccination for potential Clostridium difficile infection.
Study identification
- NCT ID
- NCT03090191
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 17,535 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 29, 2017 (Actual)
- Primary completion
- Dec 21, 2021 (Actual)
- Completion
- Dec 21, 2021 (Actual)
- Last update posted
- Feb 13, 2023
2017 – 2021
United States locations
- U.S. sites
- 220
- U.S. states
- 40
- U.S. cities
- 148
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| North Alabama Research Center, LLC | Athens | Alabama | 35611 | — |
| Medical Affiliated Research Center, Inc. | Huntsville | Alabama | 35801 | — |
| Coastal Clinical Research, LLC, An AMR Company | Mobile | Alabama | 36608 | — |
| The Pain Center of Arizona | Peoria | Arizona | 85381 | — |
| Phoenix VA Health Care System | Phoenix | Arizona | 85012 | — |
| Phoenix Clinical LLC | Phoenix | Arizona | 85014 | — |
| MedPharmics, LLC | Phoenix | Arizona | 85015 | — |
| Hope Research Institute | Phoenix | Arizona | 85018 | — |
| The Pain Center of Arizona | Phoenix | Arizona | 85018 | — |
| Clinical Research Institute of Arizona, LLC | Surprise | Arizona | 85374 | — |
| Baptist Health Center for Clinical Research | Little Rock | Arkansas | 72205 | — |
| Baptist Health Rehabilitation Institute | Little Rock | Arkansas | 72205 | — |
| Arkansas Gastroenterology | North Little Rock | Arkansas | 72117 | — |
| California Kidney Specialist | Covina | California | 91723 | — |
| Usborne Family Medicine | Covina | California | 91724 | — |
| Kaiser Permanente Daly City | Daly City | California | 94015 | — |
| Premier Health Research Center, LLC | Downey | California | 90241 | — |
| Paradigm Clinical Research Centers, Inc. | La Mesa | California | 91942 | — |
| VA Loma Linda Healthcare System Research Pharmacy | Loma Linda | California | 92357 | — |
| VA Loma Linda Healthcare System | Loma Linda | California | 92357 | — |
| Long Beach Clinical Trials Services, Inc. | Long Beach | California | 90806 | — |
| Long Beach Clinical Trials | Long Beach | California | 90806 | — |
| VA Long Beach Healthcare System | Long Beach | California | 90822 | — |
| Academic Medical Research Institute | Los Angeles | California | 90022 | — |
| Ronald Reagan UCLA Medical Center | Los Angeles | California | 90095 | — |
| UCLA CTRC Outpatient Unit | Los Angeles | California | 90095 | — |
| VA Northern California Health Care System | Mather | California | 95655 | — |
| Veterans Affairs Palo Alto Health Care System | Palo Alto | California | 94304 | — |
| Covigilant Research, LLC | Rancho Mirage | California | 92270 | — |
| Paradigm Clinical Research Centers, Inc. | Redding | California | 96001 | — |
| VA Loma Linda Healthcare System Ambulatory Care System | Redlands | California | 92373 | — |
| Covigilant Research LLC | Riverside | California | 92506 | — |
| Kaiser Permanente Roseville | Roseville | California | 95661 | — |
| One Community Health | Sacramento | California | 95811 | — |
| Kaiser Permanente Sacramento | Sacramento | California | 95815 | — |
| CTSC Clinical Research Center | Sacramento | California | 95817 | — |
| Lawrence J. Ellison Ambulatory Care Center | Sacramento | California | 95817 | — |
| University of California, Davis Medical Center | Sacramento | California | 95817 | — |
| Kaiser Permanente South Sacramento | Sacramento | California | 95823 | — |
| Breakthrough Clinical Trials | San Bernardino | California | 92408 | — |
| VA San Diego Healthcare System | San Diego | California | 92161 | — |
| California Kidney Specialists | San Dimas | California | 91773 | — |
| Kaiser Permanente San Jose | San Jose | California | 95119 | — |
| Kaiser Permanente Santa Clara | Santa Clara | California | 95051 | — |
| Alta California Medical Group | Simi Valley | California | 93065 | — |
| Kaiser Permanente Walnut Creek | Walnut Creek | California | 94596 | — |
| Clinical Trial Center University of Colorado Denver, School of Medicine | Aurora | Colorado | 80045 | — |
| University of Colorado Clinical & Translational Research Center Clinic | Aurora | Colorado | 80045 | — |
| University of Colorado Clinical & Translational Research Center Outpatient Clinic | Aurora | Colorado | 80045 | — |
| University of Colorado Denver, School of Medicine | Aurora | Colorado | 80045 | — |
| University of Colorado Department of AIP 2. Pharmacy Bulk Storage | Aurora | Colorado | 80045 | — |
| Gastroenterology Center of Connecticut, PC | Hamden | Connecticut | 06518 | — |
| Medical Research Center of Connecticut, LLC | Hamden | Connecticut | 06518 | — |
| Clinical Research Consulting, LLC | Milford | Connecticut | 06460 | — |
| Bay Pines VA Healthcare System | Bay Pines | Florida | 33744 | — |
| Florida Sleep Disorder Center of Brandon | Brandon | Florida | 33511 | — |
| Teradan Clinical Trials | Brandon | Florida | 33511 | — |
| Southeast Clinical Research | Chiefland | Florida | 32626 | — |
| Innovative Research of West FL., Inc. | Clearwater | Florida | 33756 | — |
| Alliance for Multispecialty Reseach, LLC | Coral Gables | Florida | 33134 | — |
| Omega Research Consultants, LLC | DeBary | Florida | 32713 | — |
| Accel Research Sites - DeLand Clinical Research Unit | DeLand | Florida | 32720 | — |
| Fleming Island Center for Clinical Research | Fleming Island | Florida | 32003 | — |
| Malcom Randall VA Medical Center Investigational Drug Services | Gainesville | Florida | 32608 | — |
| Malcom Randall VA Medical Center | Gainesville | Florida | 32608 | — |
| Indago Research & Health Center, Inc | Hialeah | Florida | 33012 | — |
| Clinical Neuroscience Solutions,Inc. | Jacksonville | Florida | 32256 | — |
| Multi-Specialty Research Associates, Inc. | Lake City | Florida | 32055 | — |
| Optimus U. Corp. | Miami | Florida | 33125 | — |
| Finlay Medical Research | Miami | Florida | 33126 | — |
| Doctors Research Institute | Miami | Florida | 33135 | — |
| Acevedo Clinical Research Associates | Miami | Florida | 33142 | — |
| Next Phase Research Alliance | Miami | Florida | 33144 | — |
| Charisma Medical and Research Center | Miami Lakes | Florida | 33014 | — |
| Ocean Blue Medical Research Center, Inc. | Miami Springs | Florida | 33166 | — |
| Clinical Neuroscience Solutions, Inc. dba CNS Healthcare | Orlando | Florida | 32801 | — |
| HMD Research LLC | Orlando | Florida | 32819 | — |
| Pines Care Research Center, LLC | Pembroke Pines | Florida | 33026 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Precision Clinical Research, LLC | Sunrise | Florida | 33351 | — |
| Soma Medical Center | West Palm Beach | Florida | 33406 | — |
| Atlanta VA Medical Center | Decatur | Georgia | 30033 | — |
| Meridian Clinical Research | Savannah | Georgia | 31406 | — |
| Clinical Research Atlanta | Stockbridge | Georgia | 30281 | — |
| East-West Medical Research Institute | Honolulu | Hawaii | 96814 | — |
| Snake River Research, PLLC | Idaho Falls | Idaho | 83404 | — |
| Advanced Clinical Research | Meridian | Idaho | 83642 | — |
| Solaris Clinical Research | Meridian | Idaho | 83646 | — |
| Christie Clinic, LLC | Champaign | Illinois | 61822 | — |
| Edward Hines Jr VA Hospital | Hines | Illinois | 60141 | — |
| Springfield Clinic Infectious Diseases | Springfield | Illinois | 62702 | — |
| Community Clinical Research Center | Anderson | Indiana | 46011 | — |
| Infectious Disease of Indiana, PSC | Carmel | Indiana | 46032 | — |
| St. Vincent Outpatient Treatment Center | Carmel | Indiana | 46032 | — |
| Deaconess Clinic Mt. Pleasant | Evansville | Indiana | 47725 | — |
| St. Vincent Hospital & Health Care Center | Indianapolis | Indiana | 46260 | — |
| St. Vincent Hospital and Health Care Center | Indianapolis | Indiana | 46260 | — |
| MOC Research | Mishawaka | Indiana | 46544 | — |
| Meridian Clinical Research | Sioux City | Iowa | 51106 | — |
| Alliance for Multispecialty Research, LLC | Wichita | Kansas | 67205 | — |
| Kentucky Pediatric/Adult Research | Bardstown | Kentucky | 40004 | — |
| Central Kentucky Research Associates, LLC | Lexington | Kentucky | 40509 | — |
| Tandem Clinical Research, LLC | Marrero | Louisiana | 70072 | — |
| MedPharmics, LLC | Metairie | Louisiana | 70006 | — |
| Barnum Medical Research Inc | Natchitoches | Louisiana | 71457 | — |
| Ochsner Center for Primary Care and Wellness | New Orleans | Louisiana | 70121 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| Luminis Health Anne Arundel Medical Center Infusion Center | Annapolis | Maryland | 21401 | — |
| Luminis Health Anne Arundel Medical Center | Annapolis | Maryland | 21401 | — |
| Luminis Health Research Institute: Research Office | Annapolis | Maryland | 21401 | — |
| VA Ann Arbor Healthcare System | Ann Arbor | Michigan | 48105 | — |
| ClinSite, LLC | Canton | Michigan | 48187 | — |
| Aa Mrc Llc | Flint | Michigan | 48504 | — |
| Revival Research Institute, LLC | Sterling Heights | Michigan | 48313 | — |
| Mayo Clinic Rochester, Methodist Hospital Campus | Rochester | Minnesota | 55902 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| MedPharmics | Gulfport | Mississippi | 39503 | — |
| Center for Outpatient Health | St Louis | Missouri | 63108 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110-1093 | — |
| Barnes Jewish Hospital | St Louis | Missouri | 63110 | — |
| Barnes-Jewish Hospital | St Louis | Missouri | 63110 | — |
| Center for Advanced Medicine | St Louis | Missouri | 63110 | — |
| Center For Clinical Studies | St Louis | Missouri | 63110 | — |
| Sundance Clinical Research | St Louis | Missouri | 63141 | — |
| Bozeman Health Deaconess Hospital d/b/a Bozeman Health Clinical Research | Bozeman | Montana | 59715 | — |
| Bozeman Health GI Clinic | Bozeman | Montana | 59715 | — |
| Mercury Street Medical Group, PLLC | Butte | Montana | 59701 | — |
| Meridian Clinical Research, LLC | Norfolk | Nebraska | 68701 | — |
| Barrett Clinic | Omaha | Nebraska | 68128 | — |
| Meridian Clinical Research, LLC | Omaha | Nebraska | 68134 | — |
| ID Care | Hillsborough | New Jersey | 08844 | — |
| Amici Clinical Research | Raritan | New Jersey | 08869 | — |
| South Jersey Infectious Disease | Somers Point | New Jersey | 08244 | — |
| New Mexico VA Healthcare System | Albuquerque | New Mexico | 87108 | — |
| Meridian Clinical Research LLC | Binghamton | New York | 13901 | — |
| Meridian Clinical Research, LLC | Endwell | New York | 13760 | — |
| Rochester Clinical Research | Rochester | New York | 14609 | — |
| PMG Research of Raleigh, LLC d/b/a PMG Research of Cary | Cary | North Carolina | 27518 | — |
| PMG Research of Charlotte, LLC | Charlotte | North Carolina | 28209 | — |
| Durham VAMC | Durham | North Carolina | 27705 | — |
| Duke Early Phase Clinical Research | Durham | North Carolina | 27710 | — |
| Duke University Hospital Investigational Drug Services (IDS) Pharmacy | Durham | North Carolina | 27710 | — |
| PharmQuest | Greensboro | North Carolina | 27408 | — |
| PMG Research of Hickory, LLC | Hickory | North Carolina | 28601 | — |
| PMG Research of Raleigh, LLC | Raleigh | North Carolina | 27609 | — |
| Wake Research Associates, LLC | Raleigh | North Carolina | 27612 | — |
| PMG Research of Rocky Mount, LLC | Rocky Mount | North Carolina | 27804 | — |
| PMG Research of Salisbury, LLC | Salisbury | North Carolina | 28144 | — |
| Waterway Primary Care LLC DBA Tabor City Family Medicine | Tabor City | North Carolina | 28463 | — |
| PMG Research of Wilmington, LLC | Wilmington | North Carolina | 28401 | — |
| PMG Research of Winston-Salem, LLC | Winston-Salem | North Carolina | 27103 | — |
| Progressive Medicine of the Triad, LLC | Winston-Salem | North Carolina | 27103 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58104 | — |
| Aultman Cardiology Clinical Trials | Canton | Ohio | 44710 | — |
| Aultman Hospital | Canton | Ohio | 44710 | — |
| UC Health Physicians Office Clifton | Cincinnati | Ohio | 45219 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45219 | — |
| Sterling Research Group, Ltd. | Cincinnati | Ohio | 45246 | — |
| University Of Cincinnati-Internal Medicine Division of Digestive Diseases | Cincinnati | Ohio | 45267 | — |
| Louis Stokes Cleveland VA Medical Center | Cleveland | Ohio | 44106 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Velocity Clinical Research, Inc. | Cleveland | Ohio | 44122 | — |
| OhioHealth Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Remington-Davis, Incorporated | Columbus | Ohio | 43215 | — |
| PriMED Clinical Research | Dayton | Ohio | 45419 | — |
| Great Lakes Medical Research LLC | Mentor | Ohio | 44060 | — |
| IPS Research Company | Oklahoma City | Oklahoma | 73103 | — |
| Kaiser Permanente Center For Health Research | Portland | Oregon | 97227 | — |
| Columbia Research Group, Inc. | Portland | Oregon | 97239 | — |
| VA Portland Healthcare System | Portland | Oregon | 97239 | — |
| Lehigh Valley Health Network/Network Office of Research and Innovation | Allentown | Pennsylvania | 18103 | — |
| Capital Area Research, LLC | Camp Hill | Pennsylvania | 17011 | — |
| Westminster Family Medicine | Erie | Pennsylvania | 16506 | — |
| Liberty Family Practice | Erie | Pennsylvania | 16508 | — |
| Drexel University College of Medicine | Philadelphia | Pennsylvania | 19102 | — |
| VA Pittsburgh Healthcare System | Pittsburgh | Pennsylvania | 15240 | — |
| Preferred Primary Care Physicians, Inc. | Pittsburgh | Pennsylvania | 15243 | — |
| Preferred Primary Care Physicians, Inc. | Uniontown | Pennsylvania | 15401 | — |
| Velocity Clinical Research, Providence | East Greenwich | Rhode Island | 02818 | — |
| Medical Research South, LLC | Charleston | South Carolina | 29414 | — |
| Main Street Physician's Care - Waterway | Little River | South Carolina | 29566 | — |
| Coastal Carolina Research Center | North Charleston | South Carolina | 29405 | — |
| Holston Medical Group | Bristol | Tennessee | 37620 | — |
| Internal Medicine and Pediatric Associates of Bristol, PC | Bristol | Tennessee | 37620 | — |
| PMG Research of Bristol, LLC | Bristol | Tennessee | 37620 | — |
| PMG Research, Inc. d/b/a PMG Research of Knoxville | Knoxville | Tennessee | 37912 | — |
| PMG Research,Inc. d/b/a PMG Research of Knoxville | Knoxville | Tennessee | 37938 | — |
| Clinical Neuroscience Solutions, Inc. | Memphis | Tennessee | 38119 | — |
| Trinity Clinical Research | Tullahoma | Tennessee | 37388 | — |
| Tekton Research, Inc. | Austin | Texas | 78745 | — |
| North Texas Infectious Diseases Consultants, P.A. | Dallas | Texas | 75246 | — |
| Synexus US, LP | Dallas | Texas | 75324 | — |
| Texas Health Care, PLLC | Fort Worth | Texas | 76104 | — |
| Ventavia Research Group, LLC | Fort Worth | Texas | 76104 | — |
| University of North Texas Health Science Center at Fort Worth | Fort Worth | Texas | 76107 | — |
| University of Texas Medical Branch | Galveston | Texas | 77555 | — |
| Kelsey Research Foundation | Houston | Texas | 77025 | — |
| Kelsey-Seybold Clinic | Houston | Texas | 77025 | — |
| Texas Center for Drug Development, Inc. | Houston | Texas | 77081 | — |
| Synexus US, dba Research Across America | Mesquite | Texas | 75149 | — |
| LinQ Research, LLC | Pearland | Texas | 77584 | — |
| Clinical Trials of Texas, Inc. | San Antonio | Texas | 78229 | — |
| Diagnostics Research Group | San Antonio | Texas | 78229 | — |
| South Texas Veterans Healthcare System, Audie L Murphy Hospital | San Antonio | Texas | 78229 | — |
| DM Clinical Research | Tomball | Texas | 77375 | — |
| Martin Diagnostic Clinic | Tomball | Texas | 77375 | — |
| J. Lewis Research Inc. / Foothill Family Clinic Draper | Draper | Utah | 84020 | — |
| Advanced Clinical Research/Gut Whisperer | Riverton | Utah | 84065 | — |
| J. Lewis Research, Inc./Foothill Family Clinic | Salt Lake City | Utah | 84109 | — |
| J Lewis Research, Incorporated | Salt Lake City | Utah | 84121 | — |
| J. Lewis Research, Inc. - Jordan River Family Medicine | South Jordan | Utah | 84095 | — |
| Clinical Alliance for Research & Education - Infectious Diseases, LLC | Annandale | Virginia | 22003 | — |
| Virginia Research Center LLC | Midlothian | Virginia | 23114 | — |
| Salem VAMC | Salem | Virginia | 24153 | — |
| Frandsen Family Medicine DBA Sound Medical Research | Port Orchard | Washington | 98366 | — |
| MultiCare Institute for Research & Innovation | Tacoma | Washington | 98405 | — |
| Universal Research Group, LLC | Tacoma | Washington | 98405 | — |
| Wenatchee Valley Hospital & Clinics | Wenatchee | Washington | 98801 | — |
| Marshfield Medical Center - Marshfield | Marshfield | Wisconsin | 54449 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 206 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03090191, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 13, 2023 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03090191 live on ClinicalTrials.gov.