A Study Comparing Upadacitinib (ABT-494) to Placebo in Participants With Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Biologic Disease Modifying Anti-Rheumatic Drug
Public ClinicalTrials.gov record NCT03104374. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Study Comparing Upadacitinib (ABT-494) to Placebo in Subjects With Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Biologic Disease Modifying Anti-Rheumatic Drug (bDMARD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 3 multicenter study that included two periods. Period 1 was designed to compare the safety, tolerability, and efficacy of upadacitinib 15 mg once daily (QD) and 30 mg QD versus placebo in participants with moderately to severely active Psoriatic Arthritis (PsA) who had an inadequate response to Biological Disease Modifying Anti-Rheumatic Drug (bDMARDs). Period 2 evaluated the safety, tolerability and efficacy of upadacitinib 15 mg QD and 30 mg QD in subjects with PsA who completed Period 1.
Study identification
- NCT ID
- NCT03104374
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 642 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 1, 2017 (Actual)
- Primary completion
- Jul 23, 2019 (Actual)
- Completion
- Sep 30, 2024 (Actual)
- Last update posted
- Sep 11, 2025
2017 – 2024
United States locations
- U.S. sites
- 72
- U.S. states
- 26
- U.S. cities
- 68
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Medical Group, PC /ID# 159836 | Mobile | Alabama | 36608-1787 | — |
| Arizona Arthritis & Rheumatology Research, PLLC /ID# 160047 | Mesa | Arizona | 85210-6871 | — |
| Sun Valley Arthritis Center Ltd. /ID# 161203 | Peoria | Arizona | 85381 | — |
| Duplicate_AZ Arthritis and Rheumotology Research, PLLC /ID# 160006 | Phoenix | Arizona | 85032-9306 | — |
| Osteoporosis Medical Center /ID# 161411 | Beverly Hills | California | 90211 | — |
| Covina Arthritis Clinic /ID# 159919 | Covina | California | 91722 | — |
| Triwest Research Associates /ID# 159915 | El Cajon | California | 92020 | — |
| Duplicate_Providence Medical Foundation /ID# 160005 | Fullerton | California | 92835 | — |
| C.V. Mehta MD, Med Corporation /ID# 161192 | Hemet | California | 92543 | — |
| Care Access Research, Huntington Beach /ID# 160049 | Huntington Beach | California | 92648 | — |
| Purushotham & Akther Kotha MD, Inc /ID# 159834 | La Mesa | California | 91942 | — |
| Stanford University School of Med /ID# 161402 | Stanford | California | 94305-2200 | — |
| Inland Rheum Clin Trials Inc. /ID# 159839 | Upland | California | 91786 | — |
| Medvin Clinical Research /ID# 160045 | Whittier | California | 90606 | — |
| Denver Arthritis Clinic /ID# 159899 | Denver | Colorado | 80230 | — |
| Colorado Arthritis Associates /ID# 159856 | Lakewood | Colorado | 80228 | — |
| Duplicate_Arthritis & Rheumatic Disease Specialties /ID# 161409 | Aventura | Florida | 33180 | — |
| International Medical Research /ID# 160051 | Daytona Beach | Florida | 32117 | — |
| Precision Research Organization /ID# 161293 | Miami Lakes | Florida | 33016-1501 | — |
| Duplicate_Suncoast Clinical Research /ID# 161417 | New Port Richey | Florida | 34652 | — |
| Millennium Research /ID# 159833 | Ormond Beach | Florida | 32174 | — |
| Arthritis Center, Inc. /ID# 163463 | Palm Harbor | Florida | 34684 | — |
| Gulf Region Clinical Res Inst /ID# 159860 | Pensacola | Florida | 32514 | — |
| Sarasota Arthritis Center /ID# 159854 | Sarasota | Florida | 34239 | — |
| BayCare Medical Group /ID# 161405 | St. Petersburg | Florida | 33705 | — |
| West Broward Rheumatology Associates /ID# 161412 | Tamarac | Florida | 33321 | — |
| Clinical Research of West Florida - Tampa /ID# 160069 | Tampa | Florida | 33606-1246 | — |
| Clinical Research of West Florida, Inc /ID# 159840 | Tampa | Florida | 33606-1246 | — |
| USF Health Morsani Center for /ID# 161291 | Tampa | Florida | 33612 | — |
| BayCare Medical Group, Inc. /ID# 159912 | Tampa | Florida | 33614-7101 | — |
| Florida Medical Clinic /ID# 160013 | Zephyrhills | Florida | 33542 | — |
| Jefrey D. Lieberman, MD, P.C. /ID# 159842 | Decatur | Georgia | 30033 | — |
| Atlanta Research Center for Rheumatology /ID# 161201 | Marietta | Georgia | 20060 | — |
| Velocity Clinical Research - Boise /ID# 159922 | Meridian | Idaho | 83642 | — |
| Great Lakes Clinical Trials /ID# 163438 | Chicago | Illinois | 60640 | — |
| Deerbrook Medical Associates /ID# 159815 | Libertyville | Illinois | 60048 | — |
| Duplicate_Clinic of Robert Hozman/Clinical Investigation Specialists /ID# 160068 | Skokie | Illinois | 60076 | — |
| The Arthritis & Diabetes Clinic, Inc. /ID# 161294 | Monroe | Louisiana | 71203 | — |
| Arthritis Treatment Center /ID# 160053 | Frederick | Maryland | 21204 | — |
| The Center for Rheumatology and Bone Research /ID# 159900 | Wheaton | Maryland | 20902 | — |
| Clinical Pharmacology Study Group /ID# 158712 | Worcester | Massachusetts | 01605 | — |
| Clinvest Research LLC /ID# 161208 | Springfield | Missouri | 65807 | — |
| Westroads Clinical Research /ID# 160004 | Omaha | Nebraska | 68114 | — |
| Atlantic Coast Research /ID# 159810 | Toms River | New Jersey | 08755 | — |
| Duplicate_Arthritis and Osteo Assoc /ID# 160015 | Las Cruces | New Mexico | 88011 | — |
| Center for Rheumatology LLP /ID# 167046 | Albany | New York | 12203-3710 | — |
| St. Lawrence Health System /ID# 159857 | Potsdam | New York | 13676 | — |
| DJL Clinical Research, PLLC /ID# 161414 | Charlotte | North Carolina | 28211 | — |
| Physicians East, PA /ID# 159898 | Greenville | North Carolina | 27834 | — |
| Shanahan Rheuma & Immuno /ID# 160012 | Raleigh | North Carolina | 27617 | — |
| PMG Research of Wilmington LLC /ID# 161403 | Wilmington | North Carolina | 28401 | — |
| Trinity Health Med Arts Clinic /ID# 159811 | Minot | North Dakota | 58701 | — |
| STAT Research, Inc. /ID# 161416 | Vandalia | Ohio | 45377-9464 | — |
| Health Research of Oklahoma /ID# 159913 | Oklahoma City | Oklahoma | 73103-2400 | — |
| Altoona Ctr Clinical Res /ID# 159861 | Duncansville | Pennsylvania | 16635 | — |
| University of Pittsburgh MC /ID# 161193 | Pittsburgh | Pennsylvania | 15260 | — |
| Articularis Healthcare Group, Inc d/b/a Low Country Rheumatology /ID# 163462 | Summerville | South Carolina | 29486-7887 | — |
| Rheumatology Consultants, PLLC /ID# 161408 | Knoxville | Tennessee | 37909 | — |
| Dr. Ramesh Gupta /ID# 160067 | Memphis | Tennessee | 38119 | — |
| Tekton Research, Inc. /ID# 160008 | Austin | Texas | 78745 | — |
| Diagnostic Group /ID# 161406 | Beaumont | Texas | 77701 | — |
| Arthritis and Osteoporosis Clinic Of Brazos Valley /ID# 163439 | College Station | Texas | 77845 | — |
| Adriana Pop-Moody MD Clinic PA /ID# 160009 | Corpus Christi | Texas | 78404 | — |
| Metroplex Clinical Research /ID# 159818 | Dallas | Texas | 75231 | — |
| Rheumatic Disease Clin Res Ctr /ID# 161252 | Houston | Texas | 77004 | — |
| Accurate Clinical Research /ID# 160052 | Houston | Texas | 77089 | — |
| P&I Clinical Research /ID# 159837 | Lufkin | Texas | 75904-3132 | — |
| SW Rheumatology Res. LLC /ID# 160014 | Mesquite | Texas | 75150 | — |
| DM Clinical Research - Tomball /ID# 161753 | Tomball | Texas | 77375 | — |
| Arthritis & Osteoporosis Clinic /ID# 161400 | Waco | Texas | 76710 | — |
| Arthritis Clinic of N. VA, P.C /ID# 159858 | Arlington | Virginia | 22205 | — |
| Duplicate_Swedish Medical Center /ID# 159918 | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 93 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03104374, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 11, 2025 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03104374 live on ClinicalTrials.gov.