AMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS)
Public ClinicalTrials.gov record NCT03127514. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Evaluation of the Safety, Tolerability, Efficacy and Activity of AMX0035, a Fixed Combination of Phenylbutyrate (PB) and Tauroursodeoxycholic Acid (TUDCA), for the Treatment of ALS
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The CENTAUR trial was a 2:1 (active:placebo) randomized, double-blind, placebo-controlled Phase II trial to evaluate the safety and efficacy of AMX0035 for the treatment of ALS.
Study identification
- NCT ID
- NCT03127514
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 137 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 22, 2017 (Actual)
- Primary completion
- Sep 25, 2019 (Actual)
- Completion
- Nov 24, 2019 (Actual)
- Last update posted
- May 16, 2024
2017 – 2019
United States locations
- U.S. sites
- 25
- U.S. states
- 20
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Barrow Neurological Institute | Phoenix | Arizona | 85013 | — |
| UC Irvine Medical Center | Orange | California | 92868 | — |
| Forbes Norris MDA/ALS Research Center - California Pacific Medical Center | San Francisco | California | 94114 | — |
| University of Florida Medical Center | Gainesville | Florida | 32610 | — |
| Carol and Frank Morsini Center for Advanced Health Care - University of South Florida | Tampa | Florida | 33612 | — |
| Emory University Hospital | Atlanta | Georgia | 30322 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| University of Kentucky Medical Center | Lexington | Kentucky | 40536 | — |
| Ochsner Neuroscience Institute | New Orleans | Louisiana | 70121 | — |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| University of Massachusetts Memorial Medical Center | Worcester | Massachusetts | 01655 | — |
| University of Michigan Medical Center | Ann Arbor | Michigan | 48109 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| Washington University Medical Center | St Louis | Missouri | 63110 | — |
| Neurology Associates P.C. | Lincoln | Nebraska | 68506 | — |
| Mount Sinai Beth Israel | New York | New York | 10003 | — |
| Wake Forest Baptist Medical Center | Winston-Salem | North Carolina | 27157 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43221 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| The Penn Comprehensive ALS Center | Philadelphia | Pennsylvania | 19107 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Texas Neurology, P.A. | Dallas | Texas | 75214 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| ALS Center at the Swedish Neuroscience Institute | Seattle | Washington | 98122 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03127514, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 16, 2024 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03127514 live on ClinicalTrials.gov.