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Active, not recruiting Phase 3 Interventional

A Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)

ClinicalTrials.gov ID: NCT03148418

Public ClinicalTrials.gov record NCT03148418. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Jul 28, 2026, 6:07 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

An Open-Label, Multicenter Extension and Long-Term Observational Study in Patients Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is an open-label, multicenter, non-randomized extension and long-term observational study. Participants receiving atezolizumab monotherapy or atezolizumab combined with other agent(s) or comparator agent(s) in a Genentech or Roche-sponsored study (the parent study) and who continue to receive study treatment at the time of the parent-study closure and do not have access to the study treatment locally are eligible for continued treatment in the extension study. Dosing regimen for a given participant and indication will be the same or equivalent to the respective parent study protocol. Study treatment in the extension study can continue until disease progression or beyond if the patient continues to derive clinical benefit as judged by the investigator and if allowed by the parent study or local prescribing information until death; withdrawal of study consent; unacceptable toxicity; pregnancy; patient non-compliance; or study termination by the Sponsor, whichever occurs first.

Study identification

NCT ID
NCT03148418
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Hoffmann-La Roche
Industry
Enrollment
382 participants

Conditions and interventions

Conditions

Interventions

Drug

Eligibility (public fields only)

Age range
Not listed
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Sep 19, 2017
Primary completion
Dec 30, 2026
Completion
Dec 30, 2026
Last update posted
Jul 9, 2026

2017 – 2026

United States locations

U.S. sites
44
U.S. states
25
U.S. cities
39
Facility City State ZIP Site status
HonorHealth Research Institute ? Bisgrove Scottsdale Arizona 85258
Angeles Clinic & Rsch Inst Los Angeles California 90025
UCLA Los Angeles California 90095
Kaiser Permanente - San Diego (Zion Ave) San Marcos California 92078
University Of Colorado Aurora Colorado 80045
Rocky Mountain Cancer Ctr - Denver (Williams) Denver Colorado 80218
Smilow Cancer Hospital at Yale New Haven New Haven Connecticut 06510
Georgetown University Medical Center Lombardi Cancer Center Washington D.C. District of Columbia 20057
Florida Cancer Specialists - Fort Myers (Broadway) Fort Myers Florida 33901
Hematology Oncology Associates of the Treasure Coast Port Saint Lucie Florida 34952
Florida Cancer Specialists. St. Petersburg Florida 33705
H. Lee Moffitt Cancer Center and Research Inst. Tampa Florida 33612
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital Marietta Georgia 30060
Northwestern University Chicago Illinois 60611
Rush University Medical Center Chicago Illinois 60612-3244
University Of Chicago Medical Center Chicago Illinois 60637
Ingalls Memorial Hospital Harvey Illinois 60426
Illinois Cancer Care Peoria Illinois 61615
New England Cancer Specialists Westbrook Maine 04092
Johns Hopkins Univ Med Center Baltimore Maryland 21231
Maryland Oncology Hematology, P.A. Columbia Maryland 21044
Massachusetts General Hospital. Boston Massachusetts 02114
Beth Israel Medical Center Boston Massachusetts 02215
Dana Farber Cancer Inst. Boston Massachusetts 02215
Karmanos Cancer Institute Detroit Michigan 48201
US oncology research at Minnesota Oncology Saint Louis Park Minnesota 55416
Washington University School of Medicine St Louis Missouri 63110
Comprehensive Cancer Centers of Nevada - Eastern Avenue Las Vegas Nevada 89169
Summit Medical Center Florham Park New Jersey 07932
New York Oncology Hematology, P.C. Albany New York 12206
Memorial Sloan-Kettering Cancer Center New York New York 10065
Carolina BioOncology Institute, PLCC Huntersville North Carolina 28078
Cleveland Clinic Cleveland Ohio 44195
Oncology Associates of Oregon, P.C Eugene Oregon 97401
Northwest Cancer Specialists - Portland (N Broadway) Portland Oregon 97227
Penn State Hershey Cancer Institute Hershey Pennsylvania 17033
Allegheny Cancer Center Pittsburgh Pennsylvania 15212
Sarah Cannon Res Inst Nashville Tennessee 37203
Texas Oncology - DFW Dallas Texas 75246
Tyler Cancer Center Tyler Texas 75702
Virginia Oncology Associates Norfolk Virginia 23502
Blue Ridge Cancer Care Roanoke Virginia 24014
University of Washington Seattle Cancer Care Alliance Seattle Washington 98109
Northwest Medical Specialties Tacoma Washington 98405

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 126 non-U.S. sites.

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About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT03148418, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jul 9, 2026 · Synced Jul 28, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT03148418 live on ClinicalTrials.gov.

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