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Active, not recruiting Phase 3 Interventional

A Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)

ClinicalTrials.gov ID: NCT03148418

Public ClinicalTrials.gov record NCT03148418. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 17, 2026, 8:21 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

An Open-Label, Multicenter Extension and Long-Term Observational Study in Patients Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is an open-label, multicenter, non-randomized extension and long-term observational study. Participants receiving atezolizumab monotherapy or atezolizumab combined with other agent(s) or comparator agent(s) in a Genentech or Roche-sponsored study (the parent study) and who continue to receive study treatment at the time of the parent-study closure and do not have access to the study treatment locally are eligible for continued treatment in the extension study. Dosing regimen for a given participant and indication will be the same or equivalent to the respective parent study protocol. Study treatment in the extension study can continue until disease progression or beyond if the patient continues to derive clinical benefit as judged by the investigator and if allowed by the parent study or local prescribing information until death; withdrawal of study consent; unacceptable toxicity; pregnancy; patient non-compliance; or study termination by the Sponsor, whichever occurs first.

Study identification

NCT ID
NCT03148418
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Hoffmann-La Roche
Industry
Enrollment
382 participants

Conditions and interventions

Conditions

Interventions

Drug

Eligibility (public fields only)

Age range
Not listed
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Sep 20, 2017 (Actual)
Primary completion
Nov 30, 2026 (Estimated)
Completion
Nov 30, 2026 (Estimated)
Last update posted
Oct 8, 2026

2017 – 2026

United States locations

U.S. sites
44
U.S. states
25
U.S. cities
39
Facility City State ZIP Site status
HonorHealth Research Institute ? Bisgrove Scottsdale Arizona 85258 —
Angeles Clinic & Rsch Inst Los Angeles California 90025 —
UCLA Los Angeles California 90095 —
Kaiser Permanente - San Diego (Zion Ave) San Marcos California 92078 —
University Of Colorado Aurora Colorado 80045 —
Rocky Mountain Cancer Ctr - Denver (Williams) Denver Colorado 80218 —
Smilow Cancer Hospital at Yale New Haven New Haven Connecticut 06510 —
Georgetown University Medical Center Lombardi Cancer Center Washington D.C. District of Columbia 20057 —
Florida Cancer Specialists - Fort Myers (Broadway) Fort Myers Florida 33901 —
Hematology Oncology Associates of the Treasure Coast Port Saint Lucie Florida 34952 —
Florida Cancer Specialists. St. Petersburg Florida 33705 —
H. Lee Moffitt Cancer Center and Research Inst. Tampa Florida 33612 —
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital Marietta Georgia 30060 —
Northwestern University Chicago Illinois 60611 —
Rush University Medical Center Chicago Illinois 60612-3244 —
University Of Chicago Medical Center Chicago Illinois 60637 —
Ingalls Memorial Hospital Harvey Illinois 60426 —
Illinois Cancer Care Peoria Illinois 61615 —
New England Cancer Specialists Westbrook Maine 04092 —
Johns Hopkins Univ Med Center Baltimore Maryland 21231 —
Maryland Oncology Hematology, P.A. Columbia Maryland 21044 —
Massachusetts General Hospital. Boston Massachusetts 02114 —
Beth Israel Medical Center Boston Massachusetts 02215 —
Dana Farber Cancer Inst. Boston Massachusetts 02215 —
Karmanos Cancer Institute Detroit Michigan 48201 —
US oncology research at Minnesota Oncology Saint Louis Park Minnesota 55416 —
Washington University School of Medicine St Louis Missouri 63110 —
Comprehensive Cancer Centers of Nevada - Eastern Avenue Las Vegas Nevada 89169 —
Summit Medical Center Florham Park New Jersey 07932 —
New York Oncology Hematology, P.C. Albany New York 12206 —
Memorial Sloan-Kettering Cancer Center New York New York 10065 —
Carolina BioOncology Institute, PLCC Huntersville North Carolina 28078 —
Cleveland Clinic Cleveland Ohio 44195 —
Oncology Associates of Oregon, P.C Eugene Oregon 97401 —
Northwest Cancer Specialists - Portland (N Broadway) Portland Oregon 97227 —
Penn State Hershey Cancer Institute Hershey Pennsylvania 17033 —
Allegheny Cancer Center Pittsburgh Pennsylvania 15212 —
Sarah Cannon Res Inst Nashville Tennessee 37203 —
Texas Oncology - DFW Dallas Texas 75246 —
Tyler Cancer Center Tyler Texas 75702 —
Virginia Oncology Associates Norfolk Virginia 23502 —
Blue Ridge Cancer Care Roanoke Virginia 24014 —
University of Washington Seattle Cancer Care Alliance Seattle Washington 98109 —
Northwest Medical Specialties Tacoma Washington 98405 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 126 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT03148418, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 8, 2026 · Synced Oct 17, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT03148418 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →