A Study of Talazoparib in Men With DNA Repair Defects and Metastatic Castration-Resistant Prostate Cancer
Public ClinicalTrials.gov record NCT03148795. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
TALAPRO-1: A PHASE 2, OPEN-LABEL, RESPONSE RATE STUDY OF TALAZOPARIB IN MEN WITH DNA REPAIR DEFECTS AND METASTATIC CASTRATION-RESISTANT PROSTATE CANCER WHO PREVIOUSLY RECEIVED TAXANE-BASED CHEMOTHERAPY AND PROGRESSED ON AT LEAST 1 NOVEL HORMONAL AGENT (ENZALUTAMIDE AND/OR ABIRATERONE ACETATE/PREDNISONE)
Study identification
- NCT ID
- NCT03148795
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 128 participants
Conditions and interventions
Conditions
Interventions
- Talazoparib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 3, 2017
- Primary completion
- Sep 3, 2020
- Completion
- Mar 30, 2023
- Last update posted
- Apr 4, 2024
2017 – 2023
United States locations
- U.S. sites
- 42
- U.S. states
- 11
- U.S. cities
- 26
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Oncology Associates | Tempe | Arizona | 85284 | — |
| City of Hope (City of Hope National Medical Center, City of Hope Medical Center) | Duarte | California | 91010 | — |
| City of Hope-Antelope Valley | Lancaster | California | 93534 | — |
| UC Irvine Health Investigational Drug Pharmacy | Orange | California | 92868 | — |
| University of California, Irvine Medical Center | Orange | California | 92868 | — |
| Medical Oncology Associates-SD | San Diego | California | 92123 | — |
| Sharp Outpatient Infusion Therapy Center | San Diego | California | 92123 | — |
| Sharp Rees-Stealy | San Diego | California | 92123 | — |
| Emory University Hospital | Atlanta | Georgia | 30322 | — |
| The Emory Clinic | Atlanta | Georgia | 30322 | — |
| Winship Cancer Institute, Emory University | Atlanta | Georgia | 30322 | — |
| Piedmont Cancer Institute, PC | Fayetteville | Georgia | 30214 | — |
| Piedmont Cancer Institute, PC | Newnan | Georgia | 30265 | — |
| Siteman Cancer Center - St. Peters | City of Saint Peters | Missouri | 63376 | — |
| Siteman Cancer Center - West County | Creve Coeur | Missouri | 63141 | — |
| Barnes-Jewish Hospital | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Siteman Cancer Center - South County | St Louis | Missouri | 63129 | — |
| Christian Hospital North East | St Louis | Missouri | 63136 | — |
| Weill Cornell Medical Center - New York Presbyterian Hospital | New York | New York | 10021 | — |
| Weill Cornell Medical Center-New York Presbyterian Hospital | New York | New York | 10021 | — |
| Levine Cancer Institute-Albermarle | Albemarle | North Carolina | 28001 | — |
| Carolinas Medical Center | Charlotte | North Carolina | 28203 | — |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | — |
| Levine Cancer Institute-Pineville | Charlotte | North Carolina | 28210 | — |
| Levine Cancer Institute-Southpark | Charlotte | North Carolina | 28211 | — |
| Levine Cancer Institute-University | Charlotte | North Carolina | 28262 | — |
| Levine Cancer Institute-Ballantyne | Charlotte | North Carolina | 28277 | — |
| Levine Cancer Institute- Gaston | Gastonia | North Carolina | 28054 | — |
| Levine Cancer Institute-Lincolnton | Lincolnton | North Carolina | 28092 | — |
| Levine Cancer Institute-Monroe | Monroe | North Carolina | 28112 | — |
| Carolina Urologic Research Center | Myrtle Beach | South Carolina | 29572 | — |
| Parkway Surgery Center | Myrtle Beach | South Carolina | 29572 | — |
| Levine Cancer Institute-Rock Hill | Rock Hill | South Carolina | 29732 | — |
| The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center | Tyler | Texas | 75701 | — |
| Virginia Oncology Associates | Hampton | Virginia | 23666 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| Swedish Cancer Institute Edmonds Campus | Edmonds | Washington | 98026 | — |
| Swedish Cancer Institute Issaquah Campus | Issaquah | Washington | 98029 | — |
| Swedish Cancer Institute | Seattle | Washington | 98104 | — |
| Swedish Medical Center | Seattle | Washington | 98122 | — |
| Froedtert Hospital/Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 78 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03148795, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 4, 2024 · Synced May 13, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03148795 live on ClinicalTrials.gov.