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International Registry for Men With Advanced Prostate Cancer (IRONMAN)

ClinicalTrials.gov ID: NCT03151629

Public ClinicalTrials.gov record NCT03151629. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 30, 2026, 1:06 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

Our intent is to establish the International Registry to Improve Outcomes in Men with Advanced Prostate Cancer (IRONMAN) as a prospective, international cohort of minimum 5,000 men with advanced cancer, including men with mHSPC and M0/M1 CRPC. The goal is to establish a population-based registry and recruit patients across academic and community practices from Australia, Barbados, Brazil, Canada, Ireland, Jamaica, Kenya, Nigeria, Norway, Spain, South Africa, Sweden, Switzerland, the United Kingdom (UK), and the United States (US). Target accrual number and number of participating sites are subject to change based on accrual, funding, and interest in participation by other international sites. This cohort study will facilitate a better understanding of the variation in care and treatment of advanced prostate cancer across countries and across academia and community based practices. Detailed data will be collected from patients at study enrollment and then during follow-up, for a minimum of five years. Patients will be followed prospectively for overall survival, clinically significant adverse events, comorbidities, changes in cancer treatments, and PROMs. PROMs questionnaires will be collected at enrollment and every three months thereafter. Physician Questionnaires will be collected from all participating sites at patient enrollment, time of first change in treatment and/or one year follow-up, at each subsequent change of treatment, and discontinuation of treatment. As such, this registry will help identify the treatment sequences or combinations that optimize overall survival and PROMs for men with mHSPC and M0/M1 CRPC. By collecting blood at enrollment, time of first change in treatment and/or one year follow-up (plasma, cell free DNA, buffy coat / RNA), this registry will further identify and validate molecular phenotypes of disease that predict response and resistance to specific therapeutics. Additionally, every effort will be made to collect blood specimen at each subsequent change in treatment due to progression of disease. When feasible, existing tumor tissue may be collected for correlation with described blood based studies. All samples will be used for future research. This cohort study will provide the research community with a unique biorepository to identify biomarkers of treatment response and resistance.

Study identification

NCT ID
NCT03151629
Recruitment status
Recruiting
Study type
Observational
Phase
Not listed
Enrollment
5,000 participants

Conditions and interventions

Interventions

Other

Eligibility (public fields only)

Age range
21 Years and older
Sex
Male
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 21, 2017 (Actual)
Primary completion
Jan 2031 (Estimated)
Completion
Jan 2032 (Estimated)
Last update posted
May 22, 2026

2017 – 2032

United States locations

U.S. sites
48
U.S. states
22
U.S. cities
38
Facility City State ZIP Site status
University of Alabama-Birmingham Birmingham Alabama 35233 Completed
University of Alabama- Tuscaloosa Tuscaloosa Alabama 35487 Recruiting
University of California - Los Angeles Los Angeles California 90024 Terminated
University of California San Diego San Diego California 92037 Recruiting
Yale University New Haven Connecticut 06502 Recruiting
University of Florida Gainesville Florida 32611 Terminated
Mayo Clinic Jacksonville Jacksonville Florida 32224 Recruiting
Moffitt Cancer Center Tampa Florida 33612 Recruiting
Morehouse School of Medicine Atlanta Georgia 30310 Recruiting
Emory Winship Cancer Institute Atlanta Georgia 30322 Recruiting
University of Illinois at Chicago Chicago Illinois 60607 Recruiting
Robert H. Lurie Comprehensive Cancer Center of Northwestern University Chicago Illinois 60611 Recruiting
University of Chicago Chicago Illinois 60637 Recruiting
Kishwaukee Cancer Center DeKalb Illinois 60115 Recruiting
Delnor Cancer Center Geneva Illinois 60134 Recruiting
Warrenville Cancer Center Warrenville Illinois 60555 Recruiting
Tulane University New Orleans Louisiana 70118 Active, not recruiting
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center Baltimore Maryland 21231 Recruiting
Chesapeake Urology Associates Towson Maryland 21204 Terminated
Dana-Farber Cancer Institute Boston Massachusetts 02215 Recruiting
University of Massachusetts Memorial Medical Center Worcester Massachusetts 01655 Recruiting
University of Michigan Ann Arbor Michigan 48109 Terminated
Karmanos Cancer Institute Detroit Michigan 48201 Recruiting
University of Mississippi Medical Center Jackson Mississippi 39216 Recruiting
NewYork-Presbyterian Brooklyn Methodist Hospital Brooklyn New York 11215 Recruiting
Roswell Park Comprehensive Cancer Center Buffalo New York 14203 Active, not recruiting
VA Western New York Healthcare System Buffalo New York 14215 Terminated
Columbia University Medical Center New York New York 10032 Recruiting
Memorial Sloan Kettering Cancer Center New York New York 10065 Recruiting
Weill Cornell Medical Center New York New York 10065 Recruiting
University of North Carolina at Chapel Hill Chapel Hill North Carolina 27514 Recruiting
Durham VA Medical Center Durham North Carolina 27705 Recruiting
Duke Cancer Network Durham North Carolina 27710 Recruiting
Duke University Durham North Carolina 27710 Recruiting
University Hospitals Cleveland Medical Center Cleveland Ohio 44106 Recruiting
Oregon Health & Science University Hospital Portland Oregon 97239 Recruiting
Doylestown Health Doylestown Pennsylvania 18901 Completed
Thomas Jefferson University Philadelphia Pennsylvania 19107 Active, not recruiting
Fox Chase Cancer Center - Temple Health Philadelphia Pennsylvania 19134 Recruiting
Reading Health System West Reading Pennsylvania 19611 Recruiting
Ralph H. Johnson VA Medical Center Charleston South Carolina 29401 Recruiting
William Jennings Bryan Dorn VAMC Columbia South Carolina 29209 Terminated
Memphis VA Medical Center Memphis Tennessee 38104 Recruiting
Baptist Clinical Research Institute Memphis Tennessee 38120 Recruiting
Baylor College of Medicine Houston Texas 77030 Completed
University of Virginia Charlottesville Virginia 22903 Recruiting
University of Washington Medical Center Seattle Washington 98195 Active, not recruiting
University of Wisconsin Carbone Cancer Center Madison Wisconsin 53705 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 73 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT03151629, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 22, 2026 · Synced Sep 30, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT03151629 live on ClinicalTrials.gov.

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