A Study to Evaluate Whether Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease
Public ClinicalTrials.gov record NCT03153111. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multi-center, Double-blind, Placebo-controlled Phase 2b Study to Evaluate the Efficacy and Safety of Macitentan in Subjects With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a study to evaluate whether macitentan is an effective and safe treatment for patients with heart failure with preserved ejection fraction (HFpEF) and pulmonary vascular disease. The primary objective is to evaluate whether macitentan 10 mg reduces N-terminal pro-brain natriuretic peptide (NT-pro-BNP) as compared to placebo in these patients.
Study identification
- NCT ID
- NCT03153111
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 143 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 11, 2017 (Actual)
- Primary completion
- Mar 12, 2021 (Actual)
- Completion
- Mar 12, 2021 (Actual)
- Last update posted
- Mar 30, 2025
2017 – 2021
United States locations
- U.S. sites
- 24
- U.S. states
- 17
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Arizona | Phoenix | Arizona | 85054 | — |
| Cedars Sinai Heart Institute | Beverly Hills | California | 90211 | — |
| Sharp Memorial Hospital | San Diego | California | 92123 | — |
| Harbor Ucla Medical Center | Torrance | California | 90502 | — |
| South Denver Cardiology Associates PC | Littleton | Colorado | 80120 | — |
| Northwestern University Feinberg School of Medicine | Chicago | Illinois | 60611 | — |
| University Of Iowa - Hospitals & Clinics | Iowa City | Iowa | 52242-1081 | — |
| University of Maryland | Baltimore | Maryland | 21201 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Washington University School Of Medicine | St Louis | Missouri | 63110 | — |
| Weill Cornell Medicine | New York | New York | 10021 | — |
| Peak Clinical Trials | Apex | North Carolina | 27502 | — |
| University of North Carolina (UNC) - School of Medicine | Chapel Hill | North Carolina | 27599 | — |
| The Lindner Clinical Trial Center | Cincinnati | Ohio | 45219-2906 | — |
| Lehigh Valley Health Network | Allentown | Pennsylvania | 18103 | — |
| Drexel University College of Medicine | Philadelphia | Pennsylvania | 19102 | — |
| Allegheny | Pittsburgh | Pennsylvania | 15212 | — |
| Vascular Medicine Institute University Of Pittsburgh | Pittsburgh | Pennsylvania | 15261 | — |
| AnMed Health | Anderson | South Carolina | 29621 | — |
| North Dallas Research Associates | McKinney | Texas | 75069 | — |
| Baylor Scott and White Research Institute | Temple | Texas | 76508 | — |
| Inova Heart and Vascular Institute | Falls Church | Virginia | 22042 | — |
| MultiCare Health System | Tacoma | Washington | 98405 | — |
| Aurora Saint Lukes Medical Center | Milwaukee | Wisconsin | 53215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 71 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03153111, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 30, 2025 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03153111 live on ClinicalTrials.gov.