A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS)
Public ClinicalTrials.gov record NCT03160898. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Multi-Center, Double-Blind, Randomized, Dose-Ranging, Placebo-Controlled Study to Evaluate the Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study was to assess the effect of CK-2127107 (hereafter referred to as reldesemtiv) versus placebo on respiratory function and other measures of skeletal muscle function in patients with ALS.
Study identification
- NCT ID
- NCT03160898
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 458 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 24, 2017 (Actual)
- Primary completion
- Mar 7, 2019 (Actual)
- Completion
- Mar 7, 2019 (Actual)
- Last update posted
- Sep 11, 2020
2017 – 2019
United States locations
- U.S. sites
- 47
- U.S. states
- 29
- U.S. cities
- 44
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| St. Joseph's Hospital and Medical Center - Barrow Neurological Clinics | Phoenix | Arizona | 85013 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| University of California Irvine | Orange | California | 92868 | — |
| Forbes Norris MDA/ALS Research Center | San Francisco | California | 94115 | — |
| Stanford Hospital and Clinics | Stanford | California | 94305 | — |
| University of Colorado Hospital Anschutz Outpatient Pavilion | Aurora | Colorado | 80045 | — |
| Hospital for Special Care | New Britain | Connecticut | 06053 | — |
| George Washington University Medical Faculty Associates | Washington D.C. | District of Columbia | 20037 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| Mayo Clinic | Jacksonville | Florida | 32224 | — |
| Carol & Frank Morsani Center for Advanced Healthcare - University of South Florida | Tampa | Florida | 33612 | — |
| Emory Clinic | Atlanta | Georgia | 30322 | — |
| Duchossois Center for Advanced Medicine | Chicago | Illinois | 60637 | — |
| IU Health Neuroscience Center of Excellence | Indianapolis | Indiana | 46202 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Johns Hopkins University - Outpatient Center | Baltimore | Maryland | 21287 | — |
| University of Massachusetts Memorial Medical Center/University of Massachusetts Medical School | Worcester | Massachusetts | 01655 | — |
| Michigan Medicine | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Saint Louis University, Department of Neurology | St Louis | Missouri | 63104 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Neurology Associates, P.C. | Lincoln | Nebraska | 68506 | — |
| Hospital For Special Surgery | New York | New York | 10021 | — |
| Neurological Institute, Columbia University Medical Center | New York | New York | 10032 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| Neurosciences Institute, Neurology - Charlotte | Charlotte | North Carolina | 28207 | — |
| Duke Neurological Disorders Clinic | Durham | North Carolina | 27705 | — |
| Wake Forest School of Medicine | Winston-Salem | North Carolina | 27157 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Providence Brain and Spine Institute ALS Center | Portland | Oregon | 97213 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Temple University School of Medicine | Philadelphia | Pennsylvania | 19140 | — |
| Vanderbilt University Medical Center - Clinical Research Center | Nashville | Tennessee | 37232 | — |
| Texas Neurology | Dallas | Texas | 75214 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| UTHSCSA Medical Arts and Research Center | San Antonio | Texas | 78229 | — |
| University of Vermont Medical Center | Burlington | Vermont | 05405 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22908 | — |
| VCU Health - Ambulatory Care Center (ACC) | Richmond | Virginia | 23298 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| West Virginia University, Dept. of Neurology | Morgantown | West Virginia | 26506-9180 | — |
| Froedtert Memorial Lutheran Hospital | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03160898, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 11, 2020 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03160898 live on ClinicalTrials.gov.