A Study of ONO-7475 in Patients With Acute Leukemias
Public ClinicalTrials.gov record NCT03176277. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase I/II Open Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Clinical Efficacy of ONO-7475 in Patients With Acute Leukemias or Myelodysplastic Syndromes
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
\[Updated\]: To assess the safety and tolerability of ONO-7475 monotherapy in patients with relapsed or refractory acute myeloid leukemia or relapsed or refractory myelodysplastic syndromes and to assess: i) safety and tolerability and ii) preliminary efficacy of the combination of ONO-7475 and venetoclax in patients with relapsed or refractory acute myeloid leukemia.
Study identification
- NCT ID
- NCT03176277
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 42 participants
Conditions and interventions
Conditions
Interventions
- ONO-7475 3mg once daily Drug
- ONO-7475 6mg once daily Drug
- ONO-7475 10mg once daily Drug
- ONO-7475 6mg + Venetoclax (70-400mg) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 26, 2017 (Actual)
- Primary completion
- Dec 1, 2022 (Actual)
- Completion
- Jan 20, 2023 (Actual)
- Last update posted
- Jul 15, 2024
2017 – 2023
United States locations
- U.S. sites
- 16
- U.S. states
- 13
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Southern California | Los Angeles | California | 90033 | — |
| University of California | Los Angeles | California | 90095 | — |
| Yale University School of Medicine - Yale Cancer Center | North Haven | Connecticut | 06510 | — |
| University of Florida (UF) - Shands Cancer Center | Gainesville | Florida | 32610 | — |
| Mayo Clinic - Jacksonville | Jacksonville | Florida | 32224 | — |
| The Winship Cancer Institute Emory University | Atlanta | Georgia | 30322 | — |
| Augusta University Medical Center | Augusta | Georgia | 30912 | — |
| Norton Cancer Institute | Louisville | Kentucky | 40207 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Weill Medical College of Cornell University | New York | New York | 10021 | — |
| Wake Forest University | Winston-Salem | North Carolina | 27157 | — |
| The Ohio State University (OSU) | Columbus | Ohio | 43210 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| Medical University of South Carolina - Hollins Cancer Center | Charleston | South Carolina | 29425 | — |
| MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| University of Utah - Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03176277, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 15, 2024 · Synced Oct 7, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03176277 live on ClinicalTrials.gov.