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Recruiting Phase 3 Interventional

Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery

ClinicalTrials.gov ID: NCT03180268

Public ClinicalTrials.gov record NCT03180268. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 8:10 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma

Study identification

NCT ID
NCT03180268
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
NRG Oncology
Other
Enrollment
163 participants

Conditions and interventions

Interventions

  • Biospecimen Collection Procedure
  • Clinical Observation Other
  • Intensity-Modulated Radiation Therapy Radiation
  • Laboratory Biomarker Analysis Other
  • Magnetic Resonance Imaging Procedure
  • Proton Beam Radiation Therapy Radiation
  • Quality-of-Life Assessment Other

Procedure · Other · Radiation

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Sep 11, 2017
Primary completion
Jun 14, 2027
Completion
Jun 14, 2027
Last update posted
May 6, 2026

2017 – 2027

United States locations

U.S. sites
197
U.S. states
40
U.S. cities
164
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233 Active, not recruiting
Saint Joseph's Hospital and Medical Center Phoenix Arizona 85013 Recruiting
Mayo Clinic Hospital in Arizona Phoenix Arizona 85054 Active, not recruiting
Mayo Clinic in Arizona Scottsdale Arizona 85259 Active, not recruiting
University of Arizona Cancer Center-Orange Grove Campus Tucson Arizona 85704 Suspended
Banner University Medical Center - Tucson Tucson Arizona 85719 Suspended
University of Arizona Cancer Center-North Campus Tucson Arizona 85719 Suspended
Kaiser Permanente-Anaheim Anaheim California 92806 Recruiting
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn California 95603 Recruiting
Kaiser Permanente-Bellflower Bellflower California 90706 Recruiting
Kaiser Permanente Dublin Dublin California 94568 Recruiting
Kaiser Permanente Los Angeles Medical Center Los Angeles California 90027 Recruiting
Los Angeles General Medical Center Los Angeles California 90033 Recruiting
USC / Norris Comprehensive Cancer Center Los Angeles California 90033 Recruiting
Memorial Medical Center Modesto California 95355 Recruiting
Kaiser Permanente Oakland-Broadway Oakland California 94611 Recruiting
Kaiser Permanente-Ontario Ontario California 91761 Recruiting
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California 92868 Active, not recruiting
Stanford Cancer Institute Palo Alto Palo Alto California 94304 Active, not recruiting
Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova California 95670 Recruiting
Rohnert Park Cancer Center Rohnert Park California 94928 Recruiting
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville California 95661 Recruiting
The Permanente Medical Group-Roseville Radiation Oncology Roseville California 95678 Recruiting
Sutter Medical Center Sacramento Sacramento California 95816 Recruiting
South Sacramento Cancer Center Sacramento California 95823 Recruiting
California Pacific Medical Center-Pacific Campus San Francisco California 94115 Recruiting
Kaiser Permanente Medical Center - Santa Clara Santa Clara California 95051 Recruiting
Kaiser Permanente Cancer Treatment Center South San Francisco California 94080 Recruiting
Sutter Solano Medical Center/Cancer Center Vallejo California 94589 Recruiting
Hartford Hospital Hartford Connecticut 06102 Recruiting
Yale University New Haven Connecticut 06520 Active, not recruiting
Smilow Cancer Hospital Care Center-Trumbull Trumbull Connecticut 06611 Recruiting
Helen F Graham Cancer Center Newark Delaware 19713 Active, not recruiting
Christiana Care Health System-Christiana Hospital Newark Delaware 19718 Active, not recruiting
Beebe Health Campus Rehoboth Beach Delaware 19971 Active, not recruiting
TidalHealth Nanticoke / Allen Cancer Center Seaford Delaware 19973 Active, not recruiting
Boca Raton Regional Hospital Boca Raton Florida 33486 Active, not recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida 33146 Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida 33442 Recruiting
UM Sylvester Comprehensive Cancer Center at Doral Doral Florida 33166 Recruiting
Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood Florida 33021 Recruiting
Baptist MD Anderson Cancer Center Jacksonville Florida 32207 Active, not recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136 Recruiting
Miami Cancer Institute Miami Florida 33176 Active, not recruiting
AdventHealth Orlando Orlando Florida 32803 Recruiting
AdventHealth East Orlando Orlando Florida 32822 Recruiting
Memorial Hospital West Pembroke Pines Florida 33028 Recruiting
UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida 33324 Recruiting
Moffitt Cancer Center Tampa Florida 33612 Suspended
Grady Health System Atlanta Georgia 30303 Recruiting
Emory Proton Therapy Center Atlanta Georgia 30308 Recruiting
Piedmont Hospital Atlanta Georgia 30309 Recruiting
Emory University Hospital/Winship Cancer Institute Atlanta Georgia 30322 Recruiting
Emory Saint Joseph's Hospital Atlanta Georgia 30342 Recruiting
Northside Hospital Atlanta Georgia 30342 Active, not recruiting
Northside Hospital-Forsyth Cumming Georgia 30041 Active, not recruiting
Piedmont Fayette Hospital Fayetteville Georgia 30214 Recruiting
Piedmont Newnan Hospital Newnan Georgia 30265 Recruiting
Piedmont Henry Hospital Stockbridge Georgia 30281 Recruiting
Queen's Medical Center Honolulu Hawaii 96813 Recruiting
The Cancer Center of Hawaii-Liliha Honolulu Hawaii 96817 Recruiting
Northwestern University Chicago Illinois 60611 Recruiting
Rush MD Anderson Cancer Center Chicago Illinois 60612 Recruiting
University of Illinois Chicago Illinois 60612 Recruiting
Decatur Memorial Hospital Decatur Illinois 62526 Active, not recruiting
NorthShore University HealthSystem-Evanston Hospital Evanston Illinois 60201 Suspended
Northwestern Medicine Cancer Center Delnor Geneva Illinois 60134 Recruiting
NorthShore University HealthSystem-Glenbrook Hospital Glenview Illinois 60026 Suspended
NorthShore University HealthSystem-Highland Park Hospital Highland Park Illinois 60035 Suspended
Loyola University Medical Center Maywood Illinois 60153 Recruiting
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555 Recruiting
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis Indiana 46202 Active, not recruiting
IU Health Methodist Hospital Indianapolis Indiana 46202 Active, not recruiting
Iowa Methodist Medical Center Des Moines Iowa 50309 Recruiting
University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa 52242 Active, not recruiting
University of Kansas Cancer Center Kansas City Kansas 66160 Active, not recruiting
University of Kansas Cancer Center-Overland Park Overland Park Kansas 66210 Active, not recruiting
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536 Active, not recruiting
The James Graham Brown Cancer Center at University of Louisville Louisville Kentucky 40202 Recruiting
UofL Health Medical Center Northeast Louisville Kentucky 40245 Recruiting
LSU Health Sciences Center at Shreveport Shreveport Louisiana 71103 Active, not recruiting
MaineHealth Coastal Cancer Treatment Center Bath Maine 04530 Recruiting
MaineHealth Maine Medical Center - Portland Portland Maine 04102 Recruiting
MaineHealth Cancer Care Center of York County Sanford Maine 04073 Recruiting
MaineHealth Maine Medical Center- Scarborough Scarborough Maine 04074 Recruiting
Maryland Proton Treatment Center Baltimore Maryland 21201 Active, not recruiting
University of Maryland/Greenebaum Cancer Center Baltimore Maryland 21201 Active, not recruiting
Tufts Medical Center Boston Massachusetts 02111 Recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106 Suspended
University of Michigan Rogel Cancer Center Ann Arbor Michigan 48109 Active, not recruiting
Chelsea Hospital Chelsea Michigan 48118 Suspended
Henry Ford Macomb Hospital-Clinton Township Clinton Township Michigan 48038 Recruiting
Henry Ford Hospital Detroit Michigan 48202 Recruiting
Henry Ford Health Saint John Hospital Detroit Michigan 48236 Suspended
Trinity Health Grand Rapids Hospital Grand Rapids Michigan 49503 Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154 Suspended
MyMichigan Medical Center Saginaw Saginaw Michigan 48601 Suspended
Henry Ford Health Warren Hospital Warren Michigan 48093 Suspended
Henry Ford West Bloomfield Hospital West Bloomfield Michigan 48322 Recruiting
University of Michigan Health - West Wyoming Michigan 49519 Recruiting
Essentia Health Cancer Center Duluth Minnesota 55805 Recruiting
Miller-Dwan Hospital Duluth Minnesota 55805 Recruiting
Abbott-Northwestern Hospital Minneapolis Minnesota 55407 Recruiting
Mayo Clinic in Rochester Rochester Minnesota 55905 Recruiting
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416 Recruiting
Regions Hospital Saint Paul Minnesota 55101 Recruiting
University of Mississippi Medical Center Jackson Mississippi 39216 Active, not recruiting
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376 Recruiting
MU Health - University Hospital/Ellis Fischel Cancer Center Columbia Missouri 65212 Active, not recruiting
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141 Recruiting
Washington University School of Medicine St Louis Missouri 63110 Recruiting
Siteman Cancer Center-South County St Louis Missouri 63129 Recruiting
Billings Clinic Cancer Center Billings Montana 59101 Suspended
Benefis Sletten Cancer Institute Great Falls Montana 59405 Recruiting
Logan Health Medical Center Kalispell Montana 59901 Suspended
University of Nebraska Medical Center Omaha Nebraska 68198 Active, not recruiting
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon New Hampshire 03756 Recruiting
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920 Active, not recruiting
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748 Active, not recruiting
Memorial Sloan Kettering Bergen Montvale New Jersey 07645 Active, not recruiting
Jersey Shore Medical Center Neptune City New Jersey 07753 Recruiting
Rutgers Cancer Institute of New Jersey New Brunswick New Jersey 08903 Recruiting
Rutgers New Jersey Medical School Newark New Jersey 07101 Suspended
Capital Health Medical Center-Hopewell Pennington New Jersey 08534 Recruiting
ProCure Proton Therapy Center-Somerset Somerset New Jersey 08873 Active, not recruiting
Robert Wood Johnson University Hospital Somerset Somerville New Jersey 08876 Active, not recruiting
University of New Mexico Cancer Center Albuquerque New Mexico 87106 Recruiting
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn New York 11215 Recruiting
Memorial Sloan Kettering Commack Commack New York 11725 Active, not recruiting
Memorial Sloan Kettering Westchester East White Plains New York 10604 Active, not recruiting
The New York Hospital Medical Center of Queens Flushing New York 11355 Active, not recruiting
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York New York 10032 Active, not recruiting
Memorial Sloan Kettering Cancer Center New York New York 10065 Active, not recruiting
NYP/Weill Cornell Medical Center New York New York 10065 Recruiting
University of Rochester Rochester New York 14642 Active, not recruiting
Memorial Sloan Kettering Nassau Uniondale New York 11553 Active, not recruiting
Westchester Medical Center Valhalla New York 10595 Recruiting
UNC Lineberger Comprehensive Cancer Center Chapel Hill North Carolina 27599 Active, not recruiting
Case Western Reserve University Cleveland Ohio 44106 Recruiting
Cleveland Clinic Foundation Cleveland Ohio 44195 Recruiting
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 Recruiting
Mercy Cancer Center-Elyria Elyria Ohio 44035 Suspended
Kettering Medical Center Kettering Ohio 45429 Active, not recruiting
UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio 44060 Recruiting
ProMedica Flower Hospital Sylvania Ohio 43560 Recruiting
UHHS-Westlake Medical Center Westlake Ohio 44145 Recruiting
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 Recruiting
Legacy Mount Hood Medical Center Gresham Oregon 97030 Active, not recruiting
Legacy Good Samaritan Hospital and Medical Center Portland Oregon 97210 Active, not recruiting
Saint Luke's University Hospital-Bethlehem Campus Bethlehem Pennsylvania 18015 Active, not recruiting
Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania 19317 Active, not recruiting
Geisinger Medical Center Danville Pennsylvania 17822 Recruiting
Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania 17837 Recruiting
Lewistown Hospital Lewistown Pennsylvania 17044 Recruiting
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107 Active, not recruiting
Fox Chase Cancer Center Philadelphia Pennsylvania 19111 Active, not recruiting
Temple University Hospital Philadelphia Pennsylvania 19140 Suspended
Geisinger Cancer Services-Pottsville Pottsville Pennsylvania 17901 Recruiting
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania 18711 Recruiting
Lankenau Medical Center Wynnewood Pennsylvania 19096 Suspended
Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina 29316 Active, not recruiting
Medical University of South Carolina Charleston South Carolina 29425 Active, not recruiting
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605 Active, not recruiting
Prisma Health Cancer Institute - Eastside Greenville South Carolina 29615 Active, not recruiting
Prisma Health Cancer Institute - Greer Greer South Carolina 29650 Active, not recruiting
Prisma Health Cancer Institute - Seneca Seneca South Carolina 29672 Active, not recruiting
Vanderbilt University/Ingram Cancer Center Nashville Tennessee 37232 Active, not recruiting
UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas 75390 Recruiting
M D Anderson Cancer Center Houston Texas 77030 Withdrawn
University of Texas Health Science Center at San Antonio San Antonio Texas 78229 Active, not recruiting
American Fork Hospital / Huntsman Intermountain Cancer Center American Fork Utah 84003 Recruiting
Logan Regional Hospital Logan Utah 84321 Recruiting
Intermountain Medical Center Murray Utah 84107 Recruiting
McKay-Dee Hospital Center Ogden Utah 84403 Recruiting
Utah Valley Regional Medical Center Provo Utah 84604 Recruiting
Riverton Hospital Riverton Utah 84065 Recruiting
LDS Hospital Salt Lake City Utah 84143 Recruiting
Dartmouth Cancer Center - North Saint Johnsbury Vermont 05819 Recruiting
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 Active, not recruiting
University of Washington Medical Center - Montlake Seattle Washington 98195 Active, not recruiting
Legacy Salmon Creek Hospital Vancouver Washington 98686 Active, not recruiting
Langlade Hospital and Cancer Center Antigo Wisconsin 54409 Recruiting
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701 Recruiting
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Madison Wisconsin 53718 Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792 Recruiting
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449 Recruiting
Froedtert Menomonee Falls Hospital Menomonee Falls Wisconsin 53051 Recruiting
Medical College of Wisconsin Milwaukee Wisconsin 53226 Recruiting
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548 Recruiting
Drexel Town Square Health Center Oak Creek Wisconsin 53154 Recruiting
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868 Recruiting
Aspirus Cancer Care - Stevens Point Stevens Point Wisconsin 54481 Recruiting
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482 Recruiting
UW Cancer Center at ProHealth Care Waukesha Wisconsin 53188 Recruiting
Aspirus Regional Cancer Center Wausau Wisconsin 54401 Recruiting
Marshfield Medical Center - Weston Weston Wisconsin 54476 Recruiting
Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids Wisconsin 54494 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT03180268, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 6, 2026 · Synced May 8, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT03180268 live on ClinicalTrials.gov.

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