Bezlotoxumab (MK-6072) Versus Placebo in Children With Clostridium Difficile Infection (CDI) (MK-6072-001)
Public ClinicalTrials.gov record NCT03182907. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of a Single Infusion of Bezlotoxumab (MK-6072, Human Monoclonal Antibody to C. Difficile Toxin B) in Children Aged 1 to <18 Years Receiving Antibacterial Drug Treatment for C. Difficile Infection (MODIFY III)
Study identification
- NCT ID
- NCT03182907
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Merck Sharp & Dohme LLC
- Industry
- Enrollment
- 148 participants
Conditions and interventions
Conditions
Interventions
- Bezlotoxumab Biological
- Placebo Drug
- Antibacterial drug treatment (ABD) Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 1 Year to 17 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 26, 2018
- Primary completion
- May 11, 2022
- Completion
- May 11, 2022
- Last update posted
- Jul 26, 2023
2018 – 2022
United States locations
- U.S. sites
- 21
- U.S. states
- 16
- U.S. cities
- 21
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Children's Hospital - Los Angeles ( Site 0021) | Los Angeles | California | 90027 | — |
| UCSF Medical Center ( Site 0049) | San Francisco | California | 94158 | — |
| Children's Hospital - Colorado ( Site 0013) | Aurora | Colorado | 80045 | — |
| Children's Center for Digestive Healthcare ( Site 0052) | Atlanta | Georgia | 30342 | — |
| University of Chicago ( Site 0019) | Chicago | Illinois | 60637 | — |
| Our Lady of the Lake Hospital ( Site 0007) | Baton Rouge | Louisiana | 70808 | — |
| The Johns Hopkins Rubenstein Child Health Building ( Site 0034) | Baltimore | Maryland | 21287 | — |
| Tufts Medical Center-Floating Hospital for Children ( Site 0046) | Boston | Massachusetts | 02111 | — |
| Mayo Clinic - Rochester ( Site 0004) | Rochester | Minnesota | 55905 | — |
| Washington University ( Site 0037) | St Louis | Missouri | 63110 | — |
| Columbia University Medical Center/ MSCHONY ( Site 0042) | New York | New York | 10032 | — |
| SUNY Upstate Medical Center, University Hospital ( Site 0027) | Syracuse | New York | 13210 | — |
| Montefiore Einstein Center ( Site 0041) | The Bronx | New York | 10467 | — |
| Duke University Health System ( Site 0025) | Durham | North Carolina | 27710 | — |
| Cincinnati Children's Hospital Medical Center ( Site 0024) | Cincinnati | Ohio | 45229 | — |
| University Hospitals Cleveland Medical Center ( Site 0029) | Cleveland | Ohio | 44106 | — |
| St. Jude Children's Research Hospital ( Site 0050) | Memphis | Tennessee | 38105 | — |
| Vanderbilt University Medical Center ( Site 0022) | Nashville | Tennessee | 37232 | — |
| The Children's Hospital of San Antonio ( Site 0009) | San Antonio | Texas | 78207 | — |
| Primary Children's Hospital ( Site 0001) | Salt Lake City | Utah | 84113 | — |
| Seattle Childrens Hospital ( Site 0028) | Seattle | Washington | 98105 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 54 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03182907, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 26, 2023 · Synced Jul 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03182907 live on ClinicalTrials.gov.