The TIME-2b Study: A Study of AKB-9778 (Razuprotafib), a Novel Tie 2 Activator, in Patients With Non-Proliferative Diabetic Retinopathy (NPDR)
Public ClinicalTrials.gov record NCT03197870. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 2 Double-Masked, Placebo-Controlled Study to Assess the Safety and Efficacy of Subcutaneously Administered AKB-9778 (Razuprotafib)15mg Once Daily or 15mg Twice Daily for 12 Months in Patients With Moderate to Severe Non-Proliferative Diabetic Retinopathy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the safety and efficacy of subcutaneously administered AKB-9778 15mg once daily or 15mg twice daily for 12 months in patients with moderate to severe non-proliferative diabetic retinopathy (NPDR).
Study identification
- NCT ID
- NCT03197870
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 167 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 9, 2017 (Actual)
- Primary completion
- Jan 9, 2019 (Actual)
- Completion
- Feb 9, 2019 (Actual)
- Last update posted
- Jun 27, 2023
2017 – 2019
United States locations
- U.S. sites
- 53
- U.S. states
- 23
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Retina and Vitreous Consultants | Phoenix | Arizona | 85021 | — |
| Retinal Research Institute | Phoenix | Arizona | 85053 | — |
| Retina Institute of California | Arcadia | California | 91007 | — |
| California Retina Consultants | Bakersfield | California | 93309 | — |
| Retina Vitreous Associates Medical Group | Beverly Hills | California | 90211 | — |
| Retina Consultants of Orange County | Fullerton | California | 92835 | — |
| Ophthalmic Clinical Trials San Diego | Oceanside | California | 92056 | — |
| Stanford | Palo Alto | California | 94303 | — |
| California Retina Consultants | Santa Barbara | California | 93103 | — |
| California Retina Consultants | Santa Maria | California | 93454 | — |
| Retina Consultants of Southern Colorado | Colorado Springs | Colorado | 80909 | — |
| Colorado Retina Associates | Golden | Colorado | 80401 | — |
| Rand Eye Institute | Deerfield Beach | Florida | 33064 | — |
| Center for Retina and Macular Disease | Lakeland | Florida | 33805 | — |
| Retina Specialty Institute | Pensacola | Florida | 32503 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| Georgia Retina | Marietta | Georgia | 30060 | — |
| University Retina | Oak Forest | Illinois | 60452 | — |
| Illinois Retina Associates | Oak Park | Illinois | 60304 | — |
| Midwest Eye Institute | Indianapolis | Indiana | 46290 | — |
| Wolfe Eye Clinic | West Des Moines | Iowa | 50266 | — |
| Central Plains Eye MDs | Wichita | Kansas | 67226 | — |
| Retina Associates of Kentucky | Lexington | Kentucky | 40509 | — |
| Johns Hopkins University School of Medicine | Baltimore | Maryland | 212876 | — |
| Cumberland Valley Retina Consultants PC | Hagerstown | Maryland | 21740 | — |
| Opthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| Specialty Eye Institute | Jackson | Michigan | 49202 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| Retina Center of New Jersey | Bloomfield | New Jersey | 07003 | — |
| New Jersey Retina | Edison | New Jersey | 08820 | — |
| Retinal and Ophthalmic Consultants P.C. | Northfield | New Jersey | 08225 | — |
| Eye Associates of New Mexico | Albuquerque | New Mexico | 87109 | — |
| Island Retina | Shirley | New York | 11967 | — |
| Retina Vitreous Surgeons of Central New York | Syracuse | New York | 13224 | — |
| Retina Associates of Cleveland | Beachwood | Ohio | 44122 | — |
| Cincinnati Eye Institute | Cincinnati | Ohio | 45242 | — |
| Retina Associates of Cleveland | Middleburg Heights | Ohio | 44130 | — |
| Retina Associates of Cleveland | Youngstown | Ohio | 44505 | — |
| Retina Vitreous Center | Edmond | Oklahoma | 73013 | — |
| Mid-Atlantic Retina | Bethlehem | Pennsylvania | 18017 | — |
| Tennessee Retina | Nashville | Tennessee | 37203 | — |
| Retina Research Institute of Texas | Abilene | Texas | 79606 | — |
| Texas Retina Associates | Arlington | Texas | 76012 | — |
| Austin Retina Associates | Austin | Texas | 78705 | — |
| Retina Research Center | Austin | Texas | 78705 | — |
| Texas Retina Associates | Fort Worth | Texas | 76104 | — |
| Valley Retina Institute | Harlingen | Texas | 78550 | — |
| Retina and Vitreous of Texas | Houston | Texas | 77025 | — |
| Retina Consultants of Houston | Houston | Texas | 77030 | — |
| Valley Retina Institute | McAllen | Texas | 78503 | — |
| Medical Center Ophthalmology Associates | San Antonio | Texas | 78240 | — |
| Retina Consultants of Houston | The Woodlands | Texas | 77384 | — |
| Spokane Eye Clinical Research | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03197870, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 27, 2023 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03197870 live on ClinicalTrials.gov.