A Study to Determine the Safety and Efficacy of TG-C in Subjects With Kellgren and Lawrence Grade 2 or 3 OA of the Knee
Public ClinicalTrials.gov record NCT03203330. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Phase 3 Study to Determine the Efficacy of TG-C in Subjects With Kellgren and Lawrence Grade (KLG) 2 or 3 Osteoarthritis of the Knee
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A randomized, double-blind, placebo-controlled, multi-center, phase 3 study to determine the safety and efficacy of TG-C in subjects with Kellgren and Lawrence Grade 2 or 3 Osteoarthritis of the Knee, Osteoarthritis Research Society International (OARSI) medial joint space narrowing (JSN) Grade 1 or 2 of the knee joint. TG-C is to be administered by a single intra-articular injection to the damaged joint area via ultrasound guidance. Patients will be followed for 24 months for safety and efficacy.
Study identification
- NCT ID
- NCT03203330
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 535 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 30, 2018 (Actual)
- Primary completion
- Jul 10, 2024 (Actual)
- Completion
- Aug 18, 2026 (Estimated)
- Last update posted
- Aug 20, 2026
2018 – 2026
United States locations
- U.S. sites
- 44
- U.S. states
- 19
- U.S. cities
- 40
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Jeffrey Davis | Birmingham | Alabama | 35205 | — |
| Bradly Goodman | Birmingham | Alabama | 35235 | — |
| Saima Chohan | Phoenix | Arizona | 85032 | — |
| Nebojsa Skrepnik | Tucson | Arizona | 85712 | — |
| Diraj Karnani | Apple Valley | California | 92307 | — |
| Dan La | Covina | California | 91722 | — |
| Scott Hacker | La Mesa | California | 91942 | — |
| Eric Grigsby | Napa | California | 94558 | — |
| Arthur Mabaquiao | San Diego | California | 92108 | — |
| Timothy Davis | Santa Monica | California | 90403 | — |
| Tien-I Su | Whittier | California | 90602 | — |
| Mehul Desai | Washington D.C. | District of Columbia | 20006 | — |
| David Billmeier | Daytona Beach | Florida | 32117 | — |
| Mercedes Ponce De Leon | Miami | Florida | 33135 | — |
| Aurelio Torres-Consuegra | Miami | Florida | 33144 | — |
| Edgar Gonzalez | Miami | Florida | 33144 | — |
| Cathy Barnes | New Port Richey | Florida | 34652 | — |
| Howard Chipman | Oldsmar | Florida | 34677 | — |
| Richard Linn | Sunrise | Florida | 33351 | — |
| Anand Patel | Winter Park | Florida | 32789 | — |
| Sandeep Vaid | Newnan | Georgia | 30265 | — |
| Dennis Levinson | Chicago | Illinois | 60607 | — |
| Manish Jain | Chicago | Illinois | 60640 | — |
| Hythem Shadid | Oak Brook | Illinois | 60523 | — |
| Adil Fatakia | Marrero | Louisiana | 70072 | — |
| James Nace | Baltimore | Maryland | 21215 | — |
| Melvin Churchill | Lincoln | Nebraska | 68516 | — |
| Jason Oh | New York | New York | 10075 | — |
| Brett Gilbert | Durham | North Carolina | 27704 | — |
| Jeremy Hoff | Wilmington | North Carolina | 28412 | — |
| Yogesh Mittal | Tulsa | Oklahoma | 74104 | — |
| Alan Kivitz | Duncansville | Pennsylvania | 16635 | — |
| Edward Tavel | Columbia | South Carolina | 29206 | — |
| Eric Loudermilk | Greenville | South Carolina | 29601 | — |
| Harvey Bowles | Nashville | Tennessee | 37203 | — |
| Daneshvari Solanki | Bellaire | Texas | 77401 | — |
| Amr Morsy | Dallas | Texas | 75240 | — |
| Haresh Boghara | DeSoto | Texas | 75115 | — |
| Aldo Maspons | El Paso | Texas | 79225 | — |
| Subodh Bhuchar | Houston | Texas | 77099 | — |
| Brian MacGillivray | San Antonio | Texas | 78258 | — |
| John Hemmersmeier | South Ogden | Utah | 84405 | — |
| Kristen Holtz | Charlottesville | Virginia | 22901 | — |
| Mark Hermann | Danville | Virginia | 24541 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03203330, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 20, 2026 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03203330 live on ClinicalTrials.gov.