PEN-866 in Patients With Advanced Solid Malignancies

ClinicalTrials.gov ID: NCT03221400

Public ClinicalTrials.gov record NCT03221400. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 21, 2026, 12:33 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1/2a, Open-label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Anti-tumor Activity of PEN-866 in Patients With Advanced Solid Malignancies

Study identification

NCT ID: NCT03221400
Recruitment status: Not listed
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Tarveda Therapeutics; Industry
Enrollment: 340 participants

Conditions and interventions

Conditions

Interventions

PEN-866 Sodium Drug
fluorouracil Drug
Folinic acid Drug
Niraparib Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 28, 2017
Primary completion: Dec 31, 2022
Completion: May 31, 2023
Last update posted: Feb 16, 2022

2017 – 2023

United States locations

U.S. sites: 16
U.S. states: 13
U.S. cities: 16

Facility	City	State	ZIP	Site status
Highlands Oncology Group	Springdale	Arkansas	72762	Recruiting
Sarah Cannon Reasearch Institute at HealthONE	Denver	Colorado	80218	Recruiting
Florida Cancer Specialists - South	Fort Myers	Florida	33901	Recruiting
Florida Cancer Specialists - North	St. Petersburg	Florida	33705	Recruiting
Florida Cancer Specialists - East	West Palm Beach	Florida	33401	Recruiting
National Institutes of Health / National Cancer Institute	Bethesda	Maryland	20892	Recruiting
Henry Ford	Detroit	Michigan	48202	Recruiting
Nebraska Cancer Specialists	Omaha	Nebraska	68130	Recruiting
Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	89169	Recruiting
Stephenson Cancer Center, University of Oklahoma	Oklahoma City	Oklahoma	73104	Recruiting
Sidney Kimmel Cancer Center at Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Prisma Health - Upstate	Greenville	South Carolina	29605	Recruiting
The West Clinic	Germantown	Tennessee	38138	Recruiting
Tennessee Oncology	Nashville	Tennessee	37203	Recruiting
Virginia Cancer Specialists	Fairfax	Virginia	22031	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT03221400, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 16, 2022 · Synced Jul 21, 2026

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The complete protocol, eligibility criteria, and contact information for NCT03221400 live on ClinicalTrials.gov.

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