A Phase 4 Safety and Efficacy Study to Evaluate Lesinurad 200 mg in Participants With Gout and Renal Impairment
Public ClinicalTrials.gov record NCT03226899. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 4, Study to Evaluate the Safety and Efficacy of Lesinurad 200 mg in Combination With a Xanthine Oxidase Inhibitor (XOI), Compared With an XOI Alone, in Subjects With Gout and Estimated Creatinine Clearance (eCrCl) 30 to <60 mL/Min Who Have Not Achieved Target Serum Uric Acid Levels (sUA) on an XOI Alone
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study evaluates the safety and efficacy of lesinurad administered with an XOI versus a placebo plus an XOI in gout participants who have moderate renal impairment and who are not at target level of serum urate (sUA).
Study identification
- NCT ID
- NCT03226899
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 242 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 19, 2017 (Actual)
- Primary completion
- Feb 25, 2019 (Actual)
- Completion
- Feb 25, 2019 (Actual)
- Last update posted
- Nov 4, 2021
2017 – 2019
United States locations
- U.S. sites
- 70
- U.S. states
- 29
- U.S. cities
- 62
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Central Alabama Research | Birmingham | Alabama | 35209 | — |
| Southern Arizona VA Health Care System | Tucson | Arizona | 85723 | — |
| Medvin Clinical Research | Covina | California | 91722 | — |
| Northern California Research | Sacramento | California | 95821 | — |
| Capital Nephrology Medical Group | Sacramento | California | 95825 | — |
| Inland Rheumatology Clinical Trials, Inc | Upland | California | 91786 | — |
| Medvin Clinical Research - Whittier | Whittier | California | 90602 | — |
| Western Nephrology-Westminster | Westminster | Colorado | 80031 | — |
| New England Research Associates, Llc | Trumbull | Connecticut | 06611 | — |
| Arthritis, Autoimmune, & Allergy LLC | Daytona Beach | Florida | 32117 | — |
| Riverside Clinical Research | Edgewater | Florida | 32132 | — |
| Florida Medical Research Institute | Gainesville | Florida | 32607 | — |
| Eastern Research | Hialeah | Florida | 33013 | — |
| San Marcus Research Clinic Inc | Miami | Florida | 33015 | — |
| LCC Medical Research Institute, LLC | Miami | Florida | 33126 | — |
| Savin Medical Group | Miami Lakes | Florida | 33014 | — |
| Rheumatology Associates of Central Florida | Orlando | Florida | 32806 | — |
| Omega Research Consultants, LLC | Orlando | Florida | 32810 | — |
| BayCare Medical Group, Inc. | Tampa | Florida | 33614 | — |
| Meridien Research - Tampa | Tampa | Florida | 33634 | — |
| The Kaufmann Clinic, Inc | Atlanta | Georgia | 30308 | — |
| Ellipsis Group | Atlanta | Georgia | 30342 | — |
| Rocky Mountain Diabetes and Osteoporosis Center PA | Idaho Falls | Idaho | 83404 | — |
| Clinical Investigation Specialists, Inc. - Gurnee | Gurnee | Illinois | 60031 | — |
| Nephrology Specialists | Merrillville | Indiana | 46410 | — |
| Kansas Nephrology Research Institute | Wichita | Kansas | 67214 | — |
| Center for Arthritis & Osteoporosis | Elizabethtown | Kentucky | 42701 | — |
| Four Rivers Clinical Research | Paducah | Kentucky | 42003 | — |
| Ochsner Clinic Foundation | Baton Rouge | Louisiana | 70809 | — |
| Clinical Trials Management, LLC - Northshore | Covington | Louisiana | 70433 | — |
| Clinical Trials Management LLC - Southshore | Metairie | Louisiana | 70006 | — |
| Arthritis and Diabetes Clinic | Monroe | Louisiana | 71203 | — |
| Northwest Louisiana Nephrology | Shreveport | Louisiana | 71101 | — |
| University of Massachusetts Memorial Medical Center | Worcester | Massachusetts | 01605 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Michigan Kidney Consultants | Pontiac | Michigan | 48341 | — |
| St. Clair Nephrology Research | Roseville | Michigan | 48066 | — |
| CRC of Jackson, LLC | Jackson | Mississippi | 39202 | — |
| VA Medical Center - Kansas City | Kansas City | Missouri | 64128 | — |
| Meridian Clinical Research - Norfolk, NE | Norfolk | Nebraska | 68701 | — |
| New Mexico Clinical Research & Osteoporosis Center Inc. | Albuquerque | New Mexico | 87106 | — |
| Ellipsis Research Group, LLC | Brooklyn | New York | 11215 | — |
| Buffalo VA Medical Center | Buffalo | New York | 14215 | — |
| Winthrop University Hospital | Mineola | New York | 11501 | — |
| DJL Clinical Research PLLC | Charlotte | North Carolina | 28210 | — |
| PhysiqueMed Clinical Trials | Greensboro | North Carolina | 27405 | — |
| Burke Primary Care | Morganton | North Carolina | 28655 | — |
| Trial Management Associates, LLC | Wilmington | North Carolina | 28403 | — |
| Sterling Research Group, Ltd. - Auburn | Cincinnati | Ohio | 45219 | — |
| Sterling Research Group, Ltd. - Cincinnati | Cincinnati | Ohio | 45246 | — |
| Prestige Clinical Research | Franklin | Ohio | 45005 | — |
| Columbia Research Group, Inc. | Portland | Oregon | 97239 | — |
| Northeast Clinical Research Center | Bethlehem | Pennsylvania | 18017 | — |
| Altoona Center for Clinical Research | Duncansville | Pennsylvania | 16635 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Rhode Island Hospital | East Providence | Rhode Island | 02914 | — |
| Low Country Rheumatology | Charleston | South Carolina | 29406 | — |
| Piedmont Research Partners, LLC | Fort Mill | South Carolina | 29707 | — |
| Mountain View Clinical Research - Greer | Greer | South Carolina | 29651 | — |
| Knoxville Kidney Center, PLLC | Knoxville | Tennessee | 37923 | — |
| Discovery Alliance International Inc. d/b/a Tennessee Health Research Alliance LLC | Nashville | Tennessee | 37203 | — |
| Nephrology Associates, P.C. | Nashville | Tennessee | 37205 | — |
| FMC Science | Lampasas | Texas | 76550 | — |
| P&I Clinical Research | Lufkin | Texas | 75904 | — |
| Clinical Advancement Center, PLLC | San Antonio | Texas | 78215 | — |
| Briggs Clinical Research, Inc. | San Antonio | Texas | 78224 | — |
| 3rd Coast Research Associates | Victoria | Texas | 77901 | — |
| Spectrum Medical, Inc. | Danville | Virginia | 24541 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| Clinical Research Partners, LLC | Richmond | Virginia | 23235 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 46 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03226899, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 4, 2021 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03226899 live on ClinicalTrials.gov.