A Study to Evaluate the Efficacy and Safety of JNJ-42847922 as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy
Public ClinicalTrials.gov record NCT03227224. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Double-Blind, Randomized, Parallel-Group, Placebo-Controlled, Adaptive Dose-Finding Study to Evaluate the Efficacy and Safety of JNJ-42847922 as Adjunctive Therapy to Antidepressants in Adult Subjects With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy
Study identification
- NCT ID
- NCT03227224
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Janssen Research & Development, LLC
- Industry
- Enrollment
- 287 participants
Conditions and interventions
Conditions
Interventions
- JNJ-42847922 Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 15, 2017
- Primary completion
- Jan 11, 2019
- Completion
- Jan 18, 2019
- Last update posted
- Apr 28, 2025
2017 – 2019
United States locations
- U.S. sites
- 33
- U.S. states
- 10
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| California Pharmaceutical Research Institute, Inc. | Anaheim | California | 92804 | — |
| Catalina Research Institute | Chino | California | 91710 | — |
| Synergy Clinical Research Center Of Escondido | Lemon Grove | California | 91945 | — |
| Asclepes Research | Panorama City | California | 91402 | — |
| Sharp Mesa Vista Hospital | San Diego | California | 92123 | — |
| SF-Care, Inc | San Rafael | California | 94901 | — |
| Collaborative NeuroScience Network | Torrance | California | 90502 | — |
| Elite Clinical Trials | Wildomar | California | 92595-7007 | — |
| Sarkis Clinical Trials | Gainesville | Florida | 32607 | — |
| Velocity Clinical Research, Hallandale Beach | Hallandale | Florida | 33009 | — |
| Clinical NeuroScience Solutions Inc | Jacksonville | Florida | 32256 | — |
| Innovative Clinical Research Inc | Lauderhill | Florida | 33319 | — |
| Qps-Mra, Llc | Miami | Florida | 33143 | — |
| Galiz Research | Miami Springs | Florida | 33166 | — |
| Behavioral Clinical Research , Inc | North Miami | Florida | 33162 | — |
| Clinical NeuroScience Solutions Inc | Orlando | Florida | 32801 | — |
| Compass Research LLC | Orlando | Florida | 32806 | — |
| Emory University | Atlanta | Georgia | 30022 | — |
| Radiant Research, Inc. | Atlanta | Georgia | 30328 | — |
| Atlanta Center for Medical Research | Atlanta | Georgia | 30331 | — |
| NeuroTrials Research, Inc. | Atlanta | Georgia | 30342 | — |
| Chicago Research Center | Chicago | Illinois | 60634 | — |
| Great Lakes Clinical Trials | Chicago | Illinois | 60640 | — |
| Joliet Center for Clinical Research | Joliet | Illinois | 60435 | — |
| Clinilabs | New York | New York | 10019 | — |
| Richmond Behavioral Associates | Staten Island | New York | 10312 | — |
| Clinical Trials of America | Winston-Salem | North Carolina | 27103 | — |
| Wake Forest Baptist Medical Center | Winston-Salem | North Carolina | 27157 | — |
| Neuro Behavioral Clinical Research | Canton | Ohio | 44708 | — |
| Midwest Clinical Research Center | Dayton | Ohio | 45417 | — |
| Suburban Research Associates | Media | Pennsylvania | 19063 | — |
| Family Psychiatry of The Woodlands | The Woodlands | Texas | 77381 | — |
| Core Clinical Research | Everett | Washington | 98201 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 68 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03227224, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 28, 2025 · Synced Apr 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03227224 live on ClinicalTrials.gov.