A Study of VX-445 in Healthy Subjects and Subjects With Cystic Fibrosis
Public ClinicalTrials.gov record NCT03227471. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/2 Study of VX-445 in Healthy Subjects and Subjects With Cystic Fibrosis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a first-in-human and proof-of-concept study of VX-445. The study includes 6 parts. Parts A, B, and C were conducted in healthy subjects. Parts D, E, and F were conducted in subjects with Cystic Fibrosis (CF) who are homozygous for the F508del mutation of the CF transmembrane conductance regulator (CFTR) gene (F/F genotype), or who are heterozygous for the F508del mutation and a minimal function (MF) CFTR mutation not likely to respond to TEZ, IVA, or TEZ/IVA (F/MF genotypes).
Study identification
- NCT ID
- NCT03227471
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 225 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 23, 2017 (Actual)
- Primary completion
- Mar 27, 2018 (Actual)
- Completion
- Mar 27, 2018 (Actual)
- Last update posted
- Jan 18, 2022
2017 – 2018
United States locations
- U.S. sites
- 26
- U.S. states
- 19
- U.S. cities
- 26
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner University of Arizona Medical Center | Tucson | Arizona | 85724 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Valley Children's Healthcare | Madera | California | 93636 | — |
| (Kaiser Permanente) Oakland Medical Center | Oakland | California | 96411 | — |
| National Jewish Health | Denver | Colorado | 80206 | — |
| Central Florida Pulmonary Group | Orlando | Florida | 32803 | — |
| Tampa General Hospital Cardiac and Lung Transplant Clinic | Tampa | Florida | 33606 | — |
| Children's Specialty Services at North Druid Hills | Atlanta | Georgia | 30324 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| Covance Clinical Research Unit Inc., Evansville Clinic [Parts A, B, C only] | Evansville | Indiana | 47710 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Tulane Medical Center | New Orleans | Louisiana | 70112 | — |
| Harper University Hospital | Detroit | Michigan | 48201 | — |
| Children's Respiratory and Critical Care Specialists, P.A., Children's Hospitals and Clinics of Minn | Minneapolis | Minnesota | 55404 | — |
| Morristown Medical Center | Morristown | New Jersey | 07960 | — |
| University of New Mexico School of Medicine | Albuquerque | New Mexico | 87131 | — |
| UC Health Office of Clinical Research | Cincinnati | Ohio | 45267 | — |
| University Hospitals Cleveland Medical Center/Rainbow Babies and Children's Hospital | Cleveland | Ohio | 44106 | — |
| Nationwide Children's Hospital | Columbus | Ohio | 43205 | — |
| Austin Children's Chest Associates | Austin | Texas | 78723 | — |
| The University of Vermont | Burlington | Vermont | 05401 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22908 | — |
| West Virginia University Hospitals | Morgantown | Virginia | 26506 | — |
| Children's Hospital of the King's Daughters | Norfolk | Virginia | 23507 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 12 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03227471, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 18, 2022 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03227471 live on ClinicalTrials.gov.