Study to Assess Enobosarm (GTx-024) in Postmenopausal Women With Stress Urinary Incontinence
Public ClinicalTrials.gov record NCT03241342. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Double-Blind, Placebo-Controlled, Parallel Design, Phase 2 Study to Assess Clinical Activity and Safety of Enobosarm (GTx-024) in Postmenopausal Women With Stress Urinary Incontinence
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
GTx-024 is an orally bioavailable and tissue-selective nonsteroidal selective androgen receptor modulator (SARM) that has demonstrated androgenic and anabolic activity and is currently being evaluated as a potential treatment for stress urinary incontinence (SUI) in postmenopausal women. Urinary incontinence and pelvic floor disorders are major health problems for women, especially as they age. Pelvic floor muscle relaxation has been found to correlate with lower urinary tract symptoms including SUI. Muscles of the pelvic floor and lower urinary tract are crucial for supporting the pelvic organs and micturition; however, damage to the muscles or lack of hormonal stimulation are thought to contribute to pelvic organ prolapse and urinary incontinence. Although anabolic steroids may increase muscle mass and strength, lack of oral bioavailability and known potential risks have limited their use. Nonsteroidal SARMs have potential to achieve benefits of anabolic steroid therapy (improved muscle mass, cholesterol/triglyceride levels, glucose metabolism, and bone density) with fewer adverse effects, such as hirsutism and acne, in women. Both nonclinical and clinical data suggest that SARMs may provide a new therapeutic option for pelvic floor and lower urinary tract disorders, as both testosterone and its more potent metabolite, dihydrotestosterone, have anabolic effects on muscle.
Study identification
- NCT ID
- NCT03241342
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 491 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 21, 2017 (Actual)
- Primary completion
- Sep 21, 2018 (Actual)
- Completion
- Sep 21, 2018 (Actual)
- Last update posted
- Mar 24, 2021
2017 – 2018
United States locations
- U.S. sites
- 62
- U.S. states
- 30
- U.S. cities
- 60
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Urology Center of Alabama | Homewood | Alabama | 35209 | — |
| Coastal Clinical Research Inc | Mobile | Alabama | 36608 | — |
| Alaska Clinical Research Center | Anchorage | Alaska | 99503 | — |
| Mayo Clinic Arizona | Phoenix | Arizona | 85054 | — |
| Urological Associates of Southern Arizona | Tucson | Arizona | 85741 | — |
| Women's Healthcare Research Corporation | San Diego | California | 92111 | — |
| American Institute of Research | Whittier | California | 90603 | — |
| Genitourinary Surgical Consultants | Denver | Colorado | 80220 | — |
| Urology Associates Research | Englewood | Colorado | 80113 | — |
| Women's Health Specialty Care | Farmington | Connecticut | 06032 | — |
| Coastal Connecticut Research, LLC | New London | Connecticut | 06320 | — |
| Bladder Control Center of Connecticut | Norwalk | Connecticut | 06859 | — |
| James A Simon MD PC | Washington D.C. | District of Columbia | 20036 | — |
| South Florida Medical Research | Aventura | Florida | 33180 | — |
| Tampa Bay Medical Research Inc | Clearwater | Florida | 33761 | — |
| Midland Florida Clinical Research Center LLC | DeLand | Florida | 32720 | — |
| Precision Clinical Research | Lauderdale Lakes | Florida | 33319 | — |
| Lone Star Research Center | Miami | Florida | 33145 | — |
| Medical Research of Florida | Miami | Florida | 33186 | — |
| Clinical Research Center of Florida | Pompano Beach | Florida | 33060 | — |
| Mount Vernon Clinical Research LLC | Sandy Springs | Georgia | 30328 | — |
| Clinical Research Prime | Idaho Falls | Idaho | 83221 | — |
| Idaho Urologic Institue | Meridian | Idaho | 83642 | — |
| Women's Health Institution of Illinois | Oak Lawn | Illinois | 60453 | — |
| First Urology PSC | Jeffersonville | Indiana | 47130 | — |
| Iowa Clinic | West Des Moines | Iowa | 50266 | — |
| DelRicht Clinical Research, LLC | New Orleans | Louisiana | 70115 | — |
| Regional Urology | Shreveport | Louisiana | 71106 | — |
| Chesapeake Urology Associates PA | Hanover | Maryland | 21076 | — |
| Boston Clinical Trials | Boston | Massachusetts | 02131 | — |
| Bay State clinical Trials | Watertown | Massachusetts | 02472 | — |
| Beyer Research | Kalamazoo | Michigan | 49009 | — |
| William Beaumont Hospital Urology Research | Royal Oak | Michigan | 48073 | — |
| Women's Clinic of Lincoln | Lincoln | Nebraska | 68510 | — |
| Sheldon J Freedman MD Ltd | Las Vegas | Nevada | 89144 | — |
| Premier Urology Group, LL | Edison | New Jersey | 08837 | — |
| Lawrence Obs Gyn clinical Research | Lawrenceville | New Jersey | 08648 | — |
| Delaware Valley Urology | Mount Laurel | New Jersey | 08054 | — |
| Accumed Research Associates | Garden City | New York | 11530 | — |
| Manhattan Medical Research Practice PLLC | New York | New York | 10016 | — |
| Premier Medical Group | Poughkeepsie | New York | 12601 | — |
| Circuit Clinical | West Seneca | New York | 14224 | — |
| American Health Research Inc | Charlotte | North Carolina | 28207 | — |
| Alliance Urology Specialist PA | Greensboro | North Carolina | 27403 | — |
| Eastern Carolina Women's | New Bern | North Carolina | 28562 | — |
| The Urology Group | Cincinnati | Ohio | 45212 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Aventiv Research | Columbus | Ohio | 43213 | — |
| Institute for Female Pelvic Medicine | Allentown | Pennsylvania | 18103 | — |
| Urologic Consultants of Southeastern PA LLP | Bala-Cynwyd | Pennsylvania | 19004 | — |
| University of Pennsylvania Health System | Philadelphia | Pennsylvania | 19104 | — |
| Coastal Carolina Research Center | Mt. Pleasant | South Carolina | 29464 | — |
| Carolina Urologic Research | Myrtle Beach | South Carolina | 29572 | — |
| The Jackson Clinic | Jackson | Tennessee | 38305 | — |
| Elligo - Austin Area OBGYN | Austin | Texas | 78758 | — |
| Urology Clinics of North Texas | Dallas | Texas | 75231 | — |
| Clinical Trials of Texas Incorporated | San Antonio | Texas | 78229 | — |
| Urology San Antonio Research PA | San Antonio | Texas | 78229 | — |
| Synexus Clinical Research Advantage, Inc. - Wasatch Peak Family Practice | Layton | Utah | 84041 | — |
| Urology of Virginia | Virginia Beach | Virginia | 23462 | — |
| Urology Northwest PS | Mountlake Terrace | Washington | 98043 | — |
| Seattle Womens: Health, Research, Gynocology | Seattle | Washington | 98105 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03241342, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 24, 2021 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03241342 live on ClinicalTrials.gov.