Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.

ClinicalTrials.gov ID: NCT03242642

Public ClinicalTrials.gov record NCT03242642. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:09 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation - APOLLO Trial

Study identification

NCT ID: NCT03242642
Recruitment status: Recruiting
Study type: Interventional
Phase: Not applicable
Lead sponsor: Medtronic Cardiovascular; Industry
Enrollment: 1,056 participants

Conditions and interventions

Conditions

Mitral Valve Regurgitation

Interventions

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) Device

Device

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 22, 2017
Primary completion: May 29, 2027
Completion: Sep 29, 2036
Last update posted: May 4, 2026

2017 – 2036

United States locations

U.S. sites: 78
U.S. states: 29
U.S. cities: 60

Facility	City	State	ZIP	Site status
University of Alabama Birmingham (UAB) Hospital	Birmingham	Alabama	35233	Recruiting
Abrazo Heart Hospital	Phoenix	Arizona	85018	Recruiting
Scripps Memorial Hospital	La Jolla	California	92037	Recruiting
PIH Health Good Samaritan Hospital	Los Angeles	California	90017	Recruiting
Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	90027	Recruiting
Keck Hospital of the University of Southern California, USC	Los Angeles	California	90033	Recruiting
Cedars Sinai Medical Center	Los Angeles	California	90048	Recruiting
El Camino Hospital	Mountain View	California	94040	Recruiting
Kaiser Permanente San Francisco Medical Center	San Francisco	California	94118-3100	Recruiting
Stanford Hospital and Clinics	Stanford	California	94305	Recruiting
Los Robles Regional Medical Center	Thousand Oaks	California	91360-1847	Recruiting
Hartford Hospital	Hartford	Connecticut	06102	Recruiting
Yale New Haven Hospital	New Haven	Connecticut	06510	Recruiting
MedStar Washington Hospital Center	Washington D.C.	District of Columbia	20010	Recruiting
JFK Medical Center	Atlantis	Florida	33462	Recruiting
Morton Plant	Clearwater	Florida	33756	Recruiting
HealthPark Medical Center	Fort Myers	Florida	33908	Recruiting
North Florida Regional Medical Center	Gainesville	Florida	32605	Recruiting
Baptist Medical Center Jacksonville	Jacksonville	Florida	32207	Recruiting
University of South Florida Health	Tampa	Florida	33606	Recruiting
Emory University	Atlanta	Georgia	30308	Recruiting
Piedmont Atlanta Hospital	Atlanta	Georgia	30309	Recruiting
Northwestern Memorial Hospital	Chicago	Illinois	60611	Recruiting
Rush University Medical Center	Chicago	Illinois	60612	Recruiting
MercyOne Des Moines Medical Center	Des Moines	Iowa	50314	Recruiting
University of Kansas Medical Center	Kansas City	Kansas	66160	Recruiting
University of Maryland Medical Center	Baltimore	Maryland	21201	Completed
The Johns Hopkins Hospital	Baltimore	Maryland	21287	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Brigham and Women's Hospital	Boston	Massachusetts	02115	Recruiting
Beth Israel Deaconess Medical Center	Boston	Massachusetts	02215	Recruiting
University of Michigan Health System	Ann Arbor	Michigan	48109	Recruiting
Henry Ford Saint John Hospital	Detroit	Michigan	48236	Recruiting
Corewell Health	Grand Rapids	Michigan	49503	Recruiting
Abbott Northwestern Hospital	Minneapolis	Minnesota	55407	Recruiting
M Health Fairview University of Minnesota Medical Center - East Bank	Minneapolis	Minnesota	55455	Recruiting
Barnes-Jewish Hospital	St Louis	Missouri	63110-1003	Recruiting
Providence St Patrick	Missoula	Montana	59802-4008	Recruiting
Morristown Medical Center	Morristown	New Jersey	07960	Recruiting
Jersey Shore University Medical Center	Neptune City	New Jersey	07753	Recruiting
Northwell Health North Shore University Hospital	Manhasset	New York	11030	Recruiting
NYU Langone Hospital - Long Island	Mineola	New York	11501	Recruiting
NYU Langone Medical Center	New York	New York	10016	Recruiting
The Mount Sinai Hospital	New York	New York	10029	Recruiting
New York-Presbyterian Hospital Columbia University Medical Center	New York	New York	10032	Recruiting
Montefiore Medical Center	New York	New York	10467-2401	Recruiting
Saint Francis Hospital	Roslyn	New York	11576	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Withdrawn
The Christ Hospital	Cincinnati	Ohio	45219-2906	Recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Recruiting
The Ohio State University Wexner Medical Center	Columbus	Ohio	43210	Recruiting
OhioHealth Riverside Methodist Hospital	Columbus	Ohio	43214	Recruiting
Integris Baptist Medical Center	Oklahoma City	Oklahoma	73112	Recruiting
Providence Saint Vincent Medical Center	Portland	Oregon	97225	Recruiting
Oregon Health & Science University Hospital	Portland	Oregon	97239	Recruiting
UPMC Pinnacle Harrisburg Campus	Harrisburg	Pennsylvania	17101	Recruiting
UPMC Presbyterian	Pittsburgh	Pennsylvania	15213	Recruiting
Lankenau Medical Center	Wynnewood	Pennsylvania	19096	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37203	Recruiting
Heart Hospital of Austin	Austin	Texas	78756	Recruiting
Texas Health Presbyterian Hospital Dallas	Dallas	Texas	75231	Recruiting
Baylor Jack and Jane Hamilton Heart and Vascular Hospital	Dallas	Texas	75246	Withdrawn
CHI Saint Luke's Health-Baylor Saint Luke's Medical Center	Houston	Texas	77030	Recruiting
Houston Methodist Hospital	Houston	Texas	77030	Recruiting
The University of Texas Health Science Center at Houston	Houston	Texas	77030	Recruiting
The Heart Hospital Baylor Plano	Plano	Texas	75093	Recruiting
Methodist Hospital	San Antonio	Texas	78229	Recruiting
The University of Vermont Medical Center	Burlington	Vermont	05401-1473	Recruiting
University of Virginia Medical Center	Charlottesville	Virginia	22908	Recruiting
Inova Fairfax Hospital	Fairfax	Virginia	22042	Recruiting
Sentara Norfolk General Hospital	Norfolk	Virginia	23507-1904	Recruiting
Saint Mary's Hospital/Bon Secours	Richmond	Virginia	23226	Withdrawn
Carilion Roanoke Memorial Hospital	Roanoke	Virginia	24014	Recruiting
Winchester Medical Center	Winchester	Virginia	22601	Active, not recruiting
The Swedish Medical Center Cherry Hill	Seattle	Washington	98122	Withdrawn
University of Washington (UW) Medical Center	Seattle	Washington	98195	Recruiting
Providence Sacred Heart Medical Center & Children's Hospital	Spokane	Washington	99204	Recruiting
Aurora St. Luke's Medical Center	Milwaukee	Wisconsin	53215	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT03242642, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 4, 2026 · Synced May 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT03242642 live on ClinicalTrials.gov.

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