A Study to Evaluate the Safety and Efficacy of Intravenous JNJ-64179375 Versus Oral Apixaban in Participants Undergoing Elective Total Knee Replacement Surgery
Public ClinicalTrials.gov record NCT03251482. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Double-dummy, Multicenter, Adaptive Design, Dose Escalation (Part 1) and Dose-Response (Part 2) Study to Evaluate the Safety and Efficacy of Intravenous JNJ-64179375 Versus Oral Apixaban in Subjects Undergoing Elective Total Knee Replacement Surgery
Study identification
- NCT ID
- NCT03251482
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Janssen Research & Development, LLC
- Industry
- Enrollment
- 308 participants
Conditions and interventions
Interventions
- JNJ-64179375 0.3 mg/kg Drug
- JNJ-64179375 0.6 mg/kg Drug
- JNJ-64179375 1.2 mg/kg Drug
- JNJ-64179375 (Dose to be Determined) Drug
- JNJ-64179375 A mg/kg Drug
- JNJ-64179375 B mg/kg Drug
- JNJ-64179375 C mg/kg Drug
- JNJ-64179375 D mg/kg Drug
- Placebo JNJ-64179375 Drug
- Apixaban placebo Drug
- Apixaban 2.5 mg Drug
Drug
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 12, 2017
- Primary completion
- Nov 4, 2018
- Completion
- Nov 4, 2018
- Last update posted
- Nov 24, 2019
2017 – 2018
United States locations
- U.S. sites
- 7
- U.S. states
- 5
- U.S. cities
- 7
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Research Center | Phoenix | Arizona | 85053 | — |
| Harbor-UCLA Medical Center | Torrance | California | 90509 | — |
| Denver Metro Orthopedics, PC | Englewood | Colorado | 80113 | — |
| Florida Research Associates, LLC | DeLand | Florida | 32720 | — |
| Avanza research | Pensacola | Florida | 32504 | — |
| University Orthopedic and Joint Replacement Center | Tamarac | Florida | 33321 | — |
| Memorial Hermann Memorial City Medical Center | Houston | Texas | 77024 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 96 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03251482, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 24, 2019 · Synced Jun 26, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03251482 live on ClinicalTrials.gov.