A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejection Fraction (HFpEF)
Public ClinicalTrials.gov record NCT03254485. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 2 Study Evaluating the Safety and Efficacy of Different Doses of IW-1973 Over 12 Weeks in Patients With Heart Failure With Preserved Ejection Fraction
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objective of the CAPACITY-HFpEF study is to evaluate the safety and efficacy of IW-1973 compared with placebo when administered daily for approximately 12 weeks to patients with HFpEF. The study will evaluate the effect of oral IW-1973 on peak exercise capacity in patients with HFpEF, with or without permanent or persistent atrial fibrillation.
Study identification
- NCT ID
- NCT03254485
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 196 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 45 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 7, 2017 (Actual)
- Primary completion
- Aug 19, 2019 (Actual)
- Completion
- Aug 19, 2019 (Actual)
- Last update posted
- Sep 15, 2022
2017 – 2019
United States locations
- U.S. sites
- 57
- U.S. states
- 27
- U.S. cities
- 48
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Arrhythmia Research Center | Phoenix | Arizona | 85016 | — |
| Mayo Clinic | Scottsdale | Arizona | 85259 | — |
| University of Arizona | Tucson | Arizona | 85724 | — |
| Cardiology and Medicine Clinic | Little Rock | Arkansas | 72204 | — |
| JEHM | La Mesa | California | 91941 | — |
| Axis Clinical Trials | Los Angeles | California | 90036 | — |
| JEHM | National City | California | 91950 | — |
| Valley Clinical Trials | Northridge | California | 91325 | — |
| Stanford University | Palo Alto | California | 94305 | — |
| Harbor UCLA Medical Center | Torrance | California | 90509 | — |
| Aurora Denver Cardiology | Denver | Colorado | 80218 | — |
| South Denver Cardiology Associates | Littleton | Colorado | 80120 | — |
| Holy Cross Hospital | Fort Lauderdale | Florida | 33308 | — |
| New Generation of Medical Research | Hialeah | Florida | 33016 | — |
| East Coast Institute for Research | Jacksonville | Florida | 32216 | — |
| PCRS Network, LLC | Miami | Florida | 33126 | — |
| Broward Research Center | Pembroke Pines | Florida | 33024 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| St. Luke's Regional Medical Center | Boise | Idaho | 83712 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Unity Point Health - Methodist Hospital | Peoria | Illinois | 61602 | — |
| Franciscan Physician Network - Indiana Heart Physicians | Indianapolis | Indiana | 46237 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Lousiana Heart Center | Bogalusa | Louisiana | 70427 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Boston University School of Medicine | Boston | Massachusetts | 02118 | — |
| Lahey Clinic | Burlington | Massachusetts | 01805 | — |
| Michigan Heart | Ypsilanti | Michigan | 48197 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| VA Healthcare John Cochran Medical Center | St Louis | Missouri | 63106 | — |
| Washington University | St Louis | Missouri | 63110 | — |
| The Valley Hospital | Ridgewood | New Jersey | 07450 | — |
| Mount Sinai School of Medicine | New York | New York | 10025 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Ohio State University Medical Center (OSUMC) | Columbus | Ohio | 43210 | — |
| ProMedica Toledo Hospital | Toledo | Ohio | 43606 | — |
| South Oklahoma Heart Research | Oklahoma City | Oklahoma | 73135 | — |
| Newton Clinical Research | Oklahoma City | Oklahoma | 73159 | — |
| Oklahoma Heart Institute | Tulsa | Oklahoma | 74104 | — |
| Oregon Health & Science University (OHSU) | Portland | Oregon | 97239 | — |
| PeaceHealth, Sacred Heart Physicians | Springfield | Oregon | 97477 | — |
| Research Institute of Lancaster General Health | Lancaster | Pennsylvania | 17602 | — |
| Drexel University College of Medicine | Philadelphia | Pennsylvania | 19102 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| North Dallas Research Associates | Dallas | Texas | 75069 | — |
| Texas Health Research and Education Insitute | Dallas | Texas | 75231 | — |
| Southwest Family Medicine Associates | Dallas | Texas | 75235 | — |
| Baylor University Medical Center | Dallas | Texas | 75246 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Schnitzler Cardiovascular Consultants | San Antonio | Texas | 78229 | — |
| University of Vermont Medical Center | Burlington | Vermont | 05401 | — |
| Virginia Commonwealth University Medical College of Virginia | Richmond | Virginia | 23298 | — |
| Madigan Army Medical Center | Tacoma | Washington | 98431 | — |
| Unity Point Health | Madison | Wisconsin | 53713 | — |
| University of Wisconsin - Madison | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03254485, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 15, 2022 · Synced Oct 18, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03254485 live on ClinicalTrials.gov.