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ClinicalTrials.gov record
Completed Phase 2Phase 3 Interventional Results available

Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin

ClinicalTrials.gov ID: NCT03258554

Public ClinicalTrials.gov record NCT03258554. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 21, 2026, 12:27 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Randomized Phase II/III Trial of Radiotherapy With Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy With Concurrent Cetuximab in Patients With Locoregionally Advanced Head and Neck Cancer With a Contraindication to Cisplatin

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase II/III trial studies how well radiation therapy works with durvalumab or cetuximab in treating patients with head and neck cancer that has spread to a local and/or regional area of the body who cannot take cisplatin. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cetuximab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. It is not known if radiation therapy with durvalumab will work better than the usual therapy of radiation therapy with cetuximab in treating patients with head and neck cancer.

Study identification

NCT ID
NCT03258554
Recruitment status
Completed
Study type
Interventional
Phase
Phase 2, Phase 3
Enrollment
196 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Apr 3, 2018 (Actual)
Primary completion
Sep 20, 2022 (Actual)
Completion
Sep 4, 2025 (Actual)
Last update posted
Aug 27, 2026

2018 – 2025

United States locations

U.S. sites
252
U.S. states
41
U.S. cities
196
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233 —
University of South Alabama Mitchell Cancer Institute Mobile Alabama 36688 —
Banner MD Anderson Cancer Center Gilbert Arizona 85234 —
CTCA at Western Regional Medical Center Goodyear Arizona 85338 —
Banner University Medical Center - Tucson Tucson Arizona 85719 —
University of Arizona Cancer Center-North Campus Tucson Arizona 85719 —
Kaiser Permanente-Deer Valley Medical Center Antioch California 94531 —
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn California 95603 —
Alta Bates Summit Medical Center-Herrick Campus Berkeley California 94704 —
City of Hope Comprehensive Cancer Center Duarte California 91010 —
Kaiser Permanente Dublin Dublin California 94568 —
Kaiser Permanente-Fremont Fremont California 94538 —
Fresno Cancer Center Fresno California 93720 —
Kaiser Permanente-Fresno Fresno California 93720 —
UC San Diego Moores Cancer Center La Jolla California 92093 —
Cedars Sinai Medical Center Los Angeles California 90048 —
Kaiser Permanente-Modesto Modesto California 95356 —
Kaiser Permanente Oakland-Broadway Oakland California 94611 —
Kaiser Permanente-Oakland Oakland California 94611 —
Stanford Cancer Institute Palo Alto Palo Alto California 94304 —
VA Palo Alto Health Care System Palo Alto California 94304 —
Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova California 95670 —
Kaiser Permanente-Richmond Richmond California 94801 —
Rohnert Park Cancer Center Rohnert Park California 94928 —
Kaiser Permanente-Roseville Roseville California 95661 —
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville California 95661 —
The Permanente Medical Group-Roseville Radiation Oncology Roseville California 95678 —
Kaiser Permanente Downtown Commons Sacramento California 95814 —
Sutter Medical Center Sacramento Sacramento California 95816 —
University of California Davis Comprehensive Cancer Center Sacramento California 95817 —
Kaiser Permanente-South Sacramento Sacramento California 95823 —
South Sacramento Cancer Center Sacramento California 95823 —
Kaiser Permanente-San Francisco San Francisco California 94115 —
UCSF Medical Center-Mount Zion San Francisco California 94115 —
UCSF Medical Center-Mission Bay San Francisco California 94158 —
Kaiser Permanente-Santa Teresa-San Jose San Jose California 95119 —
Kaiser Permanente San Leandro San Leandro California 94577 —
Kaiser San Rafael-Gallinas San Rafael California 94903 —
Kaiser Permanente Medical Center - Santa Clara Santa Clara California 95051 —
Kaiser Permanente-Santa Rosa Santa Rosa California 95403 —
City of Hope South Pasadena South Pasadena California 91030 —
Kaiser Permanente Cancer Treatment Center South San Francisco California 94080 —
Kaiser Permanente-South San Francisco South San Francisco California 94080 —
Kaiser Permanente-Stockton Stockton California 95210 —
Torrance Memorial Physician Network - Cancer Care Torrance California 90505 —
Torrance Memorial Medical Center Torrance California 90509 —
Gene Upshaw Memorial Tahoe Forest Cancer Center Truckee California 96161 —
Kaiser Permanente Medical Center-Vacaville Vacaville California 95688 —
Kaiser Permanente-Vallejo Vallejo California 94589 —
Kaiser Permanente-Walnut Creek Walnut Creek California 94596 —
UCHealth University of Colorado Hospital Aurora Colorado 80045 —
Penrose-Saint Francis Healthcare Colorado Springs Colorado 80907 —
UCHealth Memorial Hospital Central Colorado Springs Colorado 80909 —
Memorial Hospital North Colorado Springs Colorado 80920 —
Poudre Valley Hospital Fort Collins Colorado 80524 —
Banner McKee Medical Center Loveland Colorado 80539 —
Smilow Cancer Hospital-Hamden Care Center Hamden Connecticut 06518 —
Yale University New Haven Connecticut 06520 —
Smilow Cancer Hospital Care Center-Trumbull Trumbull Connecticut 06611 —
Smilow Cancer Hospital Care Center - Waterford Waterford Connecticut 06385 —
Beebe South Coastal Health Campus Millville Delaware 19967 —
Helen F Graham Cancer Center Newark Delaware 19713 —
Beebe Health Campus Rehoboth Beach Delaware 19971 —
UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida 33146 —
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida 33442 —
Baptist MD Anderson Cancer Center Jacksonville Florida 32207 —
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136 —
Moffitt Cancer Center Tampa Florida 33612 —
Grady Health System Atlanta Georgia 30303 —
Emory University Hospital Midtown Atlanta Georgia 30308 —
Emory University Hospital/Winship Cancer Institute Atlanta Georgia 30322 —
Augusta University Medical Center Augusta Georgia 30912 —
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii 96813 —
Queen's Medical Center Honolulu Hawaii 96813 —
The Cancer Center of Hawaii-Liliha Honolulu Hawaii 96817 —
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605 —
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687 —
Northwestern University Chicago Illinois 60611 —
John H Stroger Jr Hospital of Cook County Chicago Illinois 60612 —
Rush University Medical Center Chicago Illinois 60612 —
University of Illinois Chicago Illinois 60612 —
Decatur Memorial Hospital Decatur Illinois 62526 —
Crossroads Cancer Center Effingham Illinois 62401 —
Western Illinois Cancer Treatment Center Galesburg Illinois 61401 —
Methodist Medical Center of Illinois Peoria Illinois 61636 —
OSF Saint Francis Medical Center Peoria Illinois 61637 —
Springfield Memorial Hospital Springfield Illinois 62781 —
Carle Cancer Center Urbana Illinois 61801 —
IU Health North Hospital Carmel Indiana 46032 —
Parkview Hospital Randallia Fort Wayne Indiana 46805 —
Parkview Regional Medical Center Fort Wayne Indiana 46845 —
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis Indiana 46202 —
Sidney and Lois Eskenazi Hospital Indianapolis Indiana 46202 —
Community Cancer Center East Indianapolis Indiana 46219 —
Community Cancer Center South Indianapolis Indiana 46227 —
Community Cancer Center North Indianapolis Indiana 46256 —
Mercy Cancer Center-West Lakes Clive Iowa 50325 —
Iowa Methodist Medical Center Des Moines Iowa 50309 —
Mercy Medical Center - Des Moines Des Moines Iowa 50314 —
University of Kansas Cancer Center Kansas City Kansas 66160 —
University of Kansas Cancer Center-Overland Park Overland Park Kansas 66210 —
Salina Regional Health Center Salina Kansas 67401 —
University of Kansas Hospital-Westwood Cancer Center Westwood Kansas 66205 —
Ascension Via Christi Hospitals Wichita Wichita Kansas 67214 —
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536 —
Norton Hospital Pavilion and Medical Campus Louisville Kentucky 40202 —
The James Graham Brown Cancer Center at University of Louisville Louisville Kentucky 40202 —
Norton Brownsboro Hospital and Medical Campus Louisville Kentucky 40241 —
East Jefferson General Hospital Metairie Louisiana 70006 —
Greater Baltimore Medical Center Baltimore Maryland 21204 —
Boston Medical Center Boston Massachusetts 02118 —
Lahey Hospital and Medical Center Burlington Massachusetts 01805 —
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106 —
University of Michigan Comprehensive Cancer Center Ann Arbor Michigan 48109 —
McLaren Cancer Institute-Bay City Bay City Michigan 48706 —
Trinity Health Medical Center - Brighton Brighton Michigan 48114 —
Henry Ford Cancer Institute-Downriver Brownstown Michigan 48183 —
Trinity Health Medical Center - Canton Canton Michigan 48188 —
Chelsea Hospital Chelsea Michigan 48118 —
McLaren Cancer Institute-Clarkston Clarkston Michigan 48346 —
Henry Ford Macomb Hospital-Clinton Township Clinton Township Michigan 48038 —
Wayne State University/Karmanos Cancer Institute Detroit Michigan 48201 —
Henry Ford Hospital Detroit Michigan 48202 —
Weisberg Cancer Treatment Center Farmington Hills Michigan 48334 —
McLaren Cancer Institute-Flint Flint Michigan 48532 —
Singh and Arora Hematology Oncology PC Flint Michigan 48532 —
Allegiance Health Jackson Michigan 49201 —
Karmanos Cancer Institute at McLaren Greater Lansing Lansing Michigan 48910 —
Mid-Michigan Physicians-Lansing Lansing Michigan 48912 —
University of Michigan Health - Sparrow Lansing Lansing Michigan 48912 —
McLaren Cancer Institute-Lapeer Region Lapeer Michigan 48446 —
McLaren Cancer Institute-Macomb Mount Clemens Michigan 48043 —
McLaren Cancer Institute-Northern Michigan Petoskey Michigan 49770 —
McLaren-Port Huron Port Huron Michigan 48060 —
MyMichigan Medical Center Saginaw Saginaw Michigan 48601 —
Henry Ford West Bloomfield Hospital West Bloomfield Michigan 48322 —
Sanford Joe Lueken Cancer Center Bemidji Minnesota 56601 —
Fairview Ridges Hospital Burnsville Minnesota 55337 —
Miller-Dwan Hospital Duluth Minnesota 55805 —
Fairview Southdale Hospital Edina Minnesota 55435 —
Unity Hospital Fridley Minnesota 55432 —
Hennepin County Medical Center Minneapolis Minnesota 55415 —
Mayo Clinic in Rochester Rochester Minnesota 55905 —
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota 56303 —
Regions Hospital Saint Paul Minnesota 55101 —
Saint Francis Medical Center Cape Girardeau Missouri 63703 —
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376 —
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141 —
Washington University School of Medicine St Louis Missouri 63110 —
Mercy Hospital Saint Louis St Louis Missouri 63141 —
Billings Clinic Cancer Center Billings Montana 59101 —
Logan Health Medical Center Kalispell Montana 59901 —
Nebraska Cancer Specialists/Oncology Hematology West PC Grand Island Nebraska 68803 —
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon New Hampshire 03756 —
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920 —
Hackensack University Medical Center Hackensack New Jersey 07601 —
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748 —
Memorial Sloan Kettering Bergen Montvale New Jersey 07645 —
University of New Mexico Cancer Center Albuquerque New Mexico 87106 —
New Mexico Oncology Hematology Consultants Albuquerque New Mexico 87109 —
Roswell Park Cancer Institute Buffalo New York 14263 —
Memorial Sloan Kettering Commack Commack New York 11725 —
Memorial Sloan Kettering Westchester Harrison New York 10604 —
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York 10016 —
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York New York 10032 —
Memorial Sloan Kettering Cancer Center New York New York 10065 —
University of Rochester Rochester New York 14642 —
Stony Brook University Medical Center Stony Brook New York 11794 —
State University of New York Upstate Medical University Syracuse New York 13210 —
Montefiore Medical Center - Moses Campus The Bronx New York 10467 —
James J Peters VA Medical Center The Bronx New York 10468 —
Memorial Sloan Kettering Nassau Uniondale New York 11553 —
Atrium Health Stanly/LCI-Albemarle Albemarle North Carolina 28002 —
UNC Lineberger Comprehensive Cancer Center Chapel Hill North Carolina 27599 —
Carolinas Medical Center/Levine Cancer Institute Charlotte North Carolina 28203 —
Atrium Health Pineville/LCI-Pineville Charlotte North Carolina 28210 —
Atrium Health Cabarrus/LCI-Concord Concord North Carolina 28025 —
Margaret R Pardee Memorial Hospital Hendersonville North Carolina 28791 —
Atrium Health Union/LCI-Union Monroe North Carolina 28112 —
Sanford Roger Maris Cancer Center Fargo North Dakota 58122 —
Cleveland Clinic Mercy Hospital Canton Ohio 44708 —
Aultman Health Foundation Canton Ohio 44710 —
Geauga Hospital Chardon Ohio 44024 —
University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio 45219 —
Case Western Reserve University Cleveland Ohio 44106 —
MetroHealth Medical Center Cleveland Ohio 44109 —
Cleveland Clinic Foundation Cleveland Ohio 44195 —
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 —
Cleveland Clinic Cancer Center Mansfield Mansfield Ohio 44906 —
UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio 44060 —
North Coast Cancer Care Sandusky Ohio 44870 —
ProMedica Flower Hospital Sylvania Ohio 43560 —
University of Cincinnati Cancer Center-West Chester West Chester Ohio 45069 —
UHHS-Westlake Medical Center Westlake Ohio 44145 —
Cleveland Clinic Wooster Family Health and Surgery Center Wooster Ohio 44691 —
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 —
Good Samaritan Hospital Corvallis Oregon 97330 —
Providence Portland Medical Center Portland Oregon 97213 —
Providence Saint Vincent Medical Center Portland Oregon 97225 —
Kaiser Permanente Northwest Portland Oregon 97227 —
Jefferson Abington Hospital Abington Pennsylvania 19001 —
Crozer-Keystone Regional Cancer Center at Broomall Broomall Pennsylvania 19008 —
Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania 19317 —
Geisinger Medical Center Danville Pennsylvania 17822 —
Penn State Milton S Hershey Medical Center Hershey Pennsylvania 17033-0850 —
Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania 17837 —
Lewistown Hospital Lewistown Pennsylvania 17044 —
Forbes Hospital Monroeville Pennsylvania 15146 —
Fox Chase Cancer Center Philadelphia Pennsylvania 19111 —
Temple University Hospital Philadelphia Pennsylvania 19140 —
Allegheny General Hospital Pittsburgh Pennsylvania 15212 —
UPMC-Shadyside Hospital Pittsburgh Pennsylvania 15232 —
Guthrie Medical Group PC-Robert Packer Hospital Sayre Pennsylvania 18840 —
Reading Hospital West Reading Pennsylvania 19611 —
Wexford Health and Wellness Pavilion Wexford Pennsylvania 15090 —
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania 18711 —
Asplundh Cancer Pavilion Willow Grove Pennsylvania 19090 —
Medical University of South Carolina Charleston South Carolina 29425 —
Gibbs Cancer Center-Pelham Greer South Carolina 29651 —
Rock Hill Radiation Therapy Center Rock Hill South Carolina 29730 —
Spartanburg Medical Center Spartanburg South Carolina 29303 —
Avera Cancer Institute Sioux Falls South Dakota 57105 —
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134 —
M D Anderson Cancer Center Houston Texas 77030 —
Dartmouth Cancer Center - North Saint Johnsbury Vermont 05819 —
University of Virginia Cancer Center Charlottesville Virginia 22908 —
Sentara Norfolk General Hospital Norfolk Virginia 23507 —
VCU Massey Cancer Center at Stony Point Richmond Virginia 23235 —
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 —
University of Washington Medical Center - Montlake Seattle Washington 98195 —
West Virginia University Healthcare Morgantown West Virginia 26506 —
Langlade Hospital and Cancer Center Antigo Wisconsin 54409 —
Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin 54301 —
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin 54303 —
Aurora BayCare Medical Center Green Bay Wisconsin 54311 —
University of Wisconsin Carbone Cancer Center - Johnson Creek Johnson Creek Wisconsin 53038 —
Aurora Cancer Care-Kenosha South Kenosha Wisconsin 53142 —
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601 —
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792 —
Aurora Bay Area Medical Group-Marinette Marinette Wisconsin 54143 —
Froedtert Menomonee Falls Hospital Menomonee Falls Wisconsin 53051 —
Aurora Saint Luke's Medical Center Milwaukee Wisconsin 53215 —
Medical College of Wisconsin Milwaukee Wisconsin 53226 —
Zablocki Veterans Administration Medical Center Milwaukee Wisconsin 53295 —
ProHealth D N Greenwald Center Mukwonago Wisconsin 53149 —
ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin 53066 —
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin 53081 —
Aurora Medical Center in Summit Summit Wisconsin 53066 —
UW Cancer Center at ProHealth Care Waukesha Wisconsin 53188 —
Aspirus Regional Cancer Center Wausau Wisconsin 54401 —
Aurora West Allis Medical Center West Allis Wisconsin 53227 —
Froedtert West Bend Hospital/Kraemer Cancer Center West Bend Wisconsin 53095 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT03258554, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 27, 2026 · Synced Oct 21, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT03258554 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →