Haploidentical Bone Marrow Transplantation in Sickle Cell Patients (BMTCTN1507)
Public ClinicalTrials.gov record NCT03263559. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Reduced Intensity Conditioning for Haploidentical Bone Marrow Transplantation in Patients With Symptomatic Sickle Cell Disease. (BMTCTN1507)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase II, single arm, multi-center trial, designed to estimate the efficacy and toxicity of haploidentical bone marrow transplantation (BMT) in patients with sickle cell disease (SCD). Based on their age and entry criteria patients are stratified into two groups: (1) children with severe SCD; and (2) adults with severe SCD.
Study identification
- NCT ID
- NCT03263559
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 95 participants
Conditions and interventions
Conditions
Interventions
- Haploidentical Bone Marrow Transplantation Procedure
- Hydroxyurea Drug
- Rabbit-ATG Drug
- Thiotepa Drug
- Fludarabine Drug
- Cyclophosphamide Drug
- Total Body Irradiation Radiation
- Mesna Drug
Procedure · Drug · Radiation
Eligibility (public fields only)
- Age range
- 5 Years to 45 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 3, 2017 (Actual)
- Primary completion
- Jan 29, 2025 (Actual)
- Completion
- Jan 29, 2025 (Actual)
- Last update posted
- Jul 8, 2026
2017 – 2025
United States locations
- U.S. sites
- 32
- U.S. states
- 19
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| UCSF Benioff Children's Hospital Oakland | Oakland | California | 94609 | — |
| University of Colorado - Denver/Children's Hospital of Colorado | Aurora | Colorado | 80045 | — |
| Children's National Medical Center | Washington D.C. | District of Columbia | 20010 | — |
| University of Florida College of Medicine | Gainesville | Florida | 32610 | — |
| Nicklaus Children's Hospital/University of Miami Children's Hospital | Miami | Florida | 33155 | — |
| H. Lee Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Northside Hospital | Atlanta | Georgia | 30342 | — |
| Riley Children's Hospital at IU Health | Indianapolis | Indiana | 46020 | — |
| Indiana University Medical Center | Indianapolis | Indiana | 46202 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287 | — |
| Children's Hospital of Michigan | Detroit | Michigan | 48201 | — |
| Helen Devos Children's at Spectrum Health | Grand Rapids | Michigan | 49503 | — |
| Cardinal Glennon Children's Hospital | St Louis | Missouri | 63104 | — |
| Washington University, St. Louis | St Louis | Missouri | 63110 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Roswell Park Cancer Center | Buffalo | New York | 14203 | — |
| Northwell Health/Monter Cancer Center | Lake Success | New York | 11042 | — |
| Levine Children's Hospital | Charlotte | North Carolina | 28203 | — |
| Duke University Medical Center | Durham | North Carolina | 27705 | — |
| University Hospitals of Cleveland/Case Western | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Nationwide Children's Hospital | Columbus | Ohio | 43205-2696 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15260 | — |
| Methodist Healthcare/West Cancer Center | Memphis | Tennessee | 38104 | — |
| St. Jude Children's Research Hospital | Memphis | Tennessee | 38105 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Texas Children's Hospital (Baylor) | Houston | Texas | 77030 | — |
| University of Texas/MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Texas Transplant Institute | San Antonio | Texas | 78229 | — |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | — |
| The Medical College of Wisconsin | Wauwatosa | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03263559, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 8, 2026 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03263559 live on ClinicalTrials.gov.