Pharmacokinetics and Pharmacodynamics Study of SEG101 (Crizanlizumab) in Sickle Cell Disease (SCD) Patients With Vaso- Occlusive Crisis (VOC)
Public ClinicalTrials.gov record NCT03264989. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Multicenter, Open-Label Study to Assess PK/PD of SEG101 (Crizanlizumab), With or Without Hydroxyurea/Hydroxycarbamide, in Sickle Cell Patients With Vaso-Occlusive Crisis
Study identification
- NCT ID
- NCT03264989
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Novartis Pharmaceuticals
- Industry
- Enrollment
- 57 participants
Conditions and interventions
Conditions
Interventions
- crizanlizumab Drug
Drug
Eligibility (public fields only)
- Age range
- 16 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 18, 2017
- Primary completion
- Jun 25, 2023
- Completion
- Jun 25, 2023
- Last update posted
- Oct 8, 2024
2017 – 2023
United States locations
- U.S. sites
- 12
- U.S. states
- 7
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Novartis Investigative Site | Orange | Florida | 32763 | — |
| Novartis Investigative Site | Tampa | Florida | 33606 | — |
| Childrens Healthcare of Atlanta . | Atlanta | Georgia | 30342 | — |
| Augusta University Georgia Patient Treatment | Augusta | Georgia | 30912 | — |
| University of Maryland Medical Ctr | Baltimore | Maryland | 21201 | — |
| Childrens Hospital at Montefiore | The Bronx | New York | 10467 | — |
| Duke University Medical Center Patient Treatment | Durham | North Carolina | 27710 | — |
| East Carolina University East Carolina University | Greenville | North Carolina | 27858 | — |
| Childrens Hospital Of Philadelphia Patient Treatment | Philadelphia | Pennsylvania | 19104-4399 | — |
| Medical Uni of South Carolina Medical Univ of SC | Charleston | South Carolina | 29425 | — |
| M Francisco Gonzalez MD PA . | Columbia | South Carolina | 29203 | — |
| Carolina Blood and Cancer Care of South Carolina | Rock Hill | South Carolina | 29732 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03264989, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2024 · Synced Jul 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03264989 live on ClinicalTrials.gov.