COPD-Related Physiology and the Brain
Public ClinicalTrials.gov record NCT03269721. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Determinants of Altered Brain Structure and Function in Smokers With COPD-Related Lung Pathophysiology
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
COPD is the third leading cause of combined morbidity, disability, and mortality in the United States and is often associated with cognitive impairment. The goal of the proposed project is to examine novel pulmonary and vascular physiological mechanisms that contribute to structural brain abnormalities and cognitive dysfunction early in the course of COPD. The project will generate information to ultimately inform the development of interventions to delay or prevent cognitive dysfunction.
Study identification
- NCT ID
- NCT03269721
- Recruitment status
- Completed
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 170 participants
Conditions and interventions
Interventions
- Neuropsychological Assessment Behavioral
- Spirometry Procedure
- Arterial Blood Gas Procedure
- Diffusion Capacity of the Lung for Carbon Monoxide Procedure
- 6 Minute Walk Test Diagnostic Test
- Systemic Vascular Measures Procedure
- Blood Biomarkers Biological
- Symptom Questionnaire Measures Behavioral
- Brain MRI Procedure
Behavioral · Procedure · Diagnostic Test + 1 more
Eligibility (public fields only)
- Age range
- 30 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 30, 2017
- Primary completion
- Apr 29, 2025
- Completion
- Apr 29, 2025
- Last update posted
- Dec 23, 2025
2017 – 2025
United States locations
- U.S. sites
- 1
- U.S. states
- 1
- U.S. cities
- 1
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Iowa | Iowa City | Iowa | 52242 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03269721, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 23, 2025 · Synced Sep 1, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03269721 live on ClinicalTrials.gov.