ClinicalTrials.gov record
Clinical Trial of Neoadjuvant Chemotherapy With Atezolizumab or Placebo in Patients With Triple-Negative Breast Cancer Followed After Surgery by Atezolizumab or Placebo
ClinicalTrials.gov ID: NCT03281954
Public ClinicalTrials.gov record NCT03281954. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Phase III Clinical Trial of Neoadjuvant Chemotherapy With Atezolizumab or Placebo in Patients With Triple-Negative Breast Cancer Followed by Adjuvant Continuation of Atezolizumab or Placebo
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to learn if the usual chemotherapy given before surgery (neoadjuvant therapy) for breast cancer plus the experimental drug, atezolizumab, is better than the usual chemotherapy plus a placebo. (A placebo is a drug that looks like the study drug but contains no medication.) The usual chemotherapy in this study is paclitaxel (WP) and carboplatin followed by doxorubicin and cyclophosphamide (AC) or epirubicin and cyclophosphamide (EC). Usually, after neoadjuvant therapy and surgery for triple negative breast cancer, no additional treatment is given unless the cancer returns. This study will also look at continuing treatment after surgery with atezolizumab or the placebo. To be better, atezolizumab given with the neoadjuvant therapy should be better at: 1) decreasing the amount of tumor in the breast than the placebo given with the usual chemotherapy and 2) decreasing the chance of the cancer from returning after surgery. Another purpose of this study is to test the good and bad effects of atezolizumab when added to the usual chemotherapy. Atezolizumab may keep your cancer from growing but it can also cause side effects.
Study identification
- NCT ID
- NCT03281954
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,550 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 19, 2017 (Actual)
- Primary completion
- Dec 31, 2024 (Estimated)
- Completion
- Nov 30, 2027 (Estimated)
- Last update posted
- Apr 8, 2024
2017 – 2027
United States locations
- U.S. sites
- 212
- U.S. states
- 32
- U.S. cities
- 167
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of South Alabama Mitchell Cancer Institute | Mobile | Alabama | 36604 | — |
| Katmai Oncology Group | Anchorage | Alaska | 99508 | — |
| St. Bernard's Medical Center | Jonesboro | Arkansas | 72401 | — |
| St. Bernard's Medical Center | Paragould | Arkansas | 72450 | — |
| Kaiser Permanente-Anaheim | Anaheim | California | 92806 | — |
| Kaiser Permanente-Baldwin Park | Baldwin Park | California | 91706 | — |
| Kaiser Permanente-Bellflower | Bellflower | California | 90706 | — |
| Arrowhead Regional Medical Center | Colton | California | 92324 | — |
| City of Hope | Duarte | California | 91010 | — |
| Kaiser Permanente-Fontana | Fontana | California | 92335 | — |
| Kaiser Permanente-Harbor City | Harbor City | California | 90710 | — |
| Kaiser Permanente-Irvine | Irvine | California | 92618 | — |
| Cancer and Blood Specialty Clinic | Los Alamitos | California | 90720 | — |
| Kaiser Permanente-Sunset | Los Angeles | California | 90027 | — |
| Kaiser Permanente-West Los Angeles | Los Angeles | California | 90034 | — |
| Kaiser Permanente-Panorama City | Panorama City | California | 91402 | — |
| Kaiser Permanente-Riverside | Riverside | California | 92505 | — |
| Kaiser Permanente Medical Group | San Diego | California | 92108 | — |
| Kaiser Permanente-Zion | San Diego | California | 92120 | — |
| Kaiser Permanente - Otay | San Diego | California | 92153 | — |
| Kaiser Permanente- San Marcos | San Marcos | California | 92078 | — |
| City of Hope - South Pasadena | South Pasadena | California | 91030 | — |
| Torrance Memorial Physician Network | Torrance | California | 90505 | — |
| City of Hope - Upland | Upland | California | 91786 | — |
| PIH Health | Whittier | California | 90602 | — |
| Kaiser Permanente-Woodland Hills | Woodland Hills | California | 91367 | — |
| Mount Sinai Comprehensive Cancer Center Aventura | Aventura | Florida | 33180 | — |
| Memorial Healthcare System Office of Human Research | Hollywood | Florida | 33021 | — |
| Mount Sinai Comprehensive Cancer Center | Miami Beach | Florida | 33140 | — |
| UF Health Cancer Center at Orlando Health | Orlando | Florida | 32806 | — |
| Gwinnett Hospital System Center for Cancer Care | Duluth | Georgia | 30096 | — |
| Gwinnett Hospital System Center for Cancer Care | Lawrenceville | Georgia | 30046 | — |
| Gwinnett Hospital System Center for Cancer Care | Snellville | Georgia | 30078 | — |
| Illinois Cancer Care-Bloomington | Bloomington | Illinois | 61704 | — |
| John H. Stroger, Jr. Hospital of Cook County | Chicago | Illinois | 60612 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Affiliated Oncologists | Chicago Ridge | Illinois | 60415 | — |
| Cancer Care Specialists of Central Illinois | Decatur | Illinois | 62526 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Emhurst Memorial Nancy W. Knowles Cancer Center | Elmhurst | Illinois | 60126 | — |
| Illinois Cancer Care-Galesburg | Galesburg | Illinois | 61401 | — |
| Edward Cancer Center | Naperville | Illinois | 60540 | — |
| Illinois Cancer Care-Ottawa | Ottawa | Illinois | 61350 | — |
| Illinois Cancer Care PC | Peoria | Illinois | 61615 | — |
| Illinois Cancer Care-Peru | Peru | Illinois | 61354 | — |
| Edward Cancer Center Plainfield | Plainfield | Illinois | 60585 | — |
| Cancer Care Specialists of Central Illinois-Swansea | Swansea | Illinois | 62226 | — |
| Fort Wayne Medical Oncology and Hematology Inc (W. Jefferson Blvd) | Fort Wayne | Indiana | 46804 | — |
| Fort Wayne Medical Oncology and Hematology Inc (Parkview Plaza) | Fort Wayne | Indiana | 46845 | — |
| Mercy Medical Center Hall-Perrine Cancer Center | Cedar Rapids | Iowa | 52403 | — |
| Cancer Center of Kansas - Chanute | Chanute | Kansas | 66720 | — |
| Cancer Center of Kansas - Dodge City | Dodge City | Kansas | 67801 | — |
| Susan B. Allen Memorial Hosptial | El Dorado | Kansas | 67042 | — |
| Cancer Center at Mercy - W. Laurel | Independence | Kansas | 67301 | — |
| Kingman Community Hospital | Kingman | Kansas | 67068 | — |
| Southwest Medical Center | Liberal | Kansas | 67901 | — |
| McPherson Center for Health | McPherson | Kansas | 67460 | — |
| Newton Medical Center | Newton | Kansas | 67114 | — |
| Labette Health | Parsons | Kansas | 67357 | — |
| Pratt Regional Medical Center | Pratt | Kansas | 67124 | — |
| Cancer Center of Kansas - Salina | Salina | Kansas | 67401 | — |
| Cancer Center of Kansas - Wichita | Wichita | Kansas | 67214 | — |
| Cancer Center of Kansas | Wichita | Kansas | 67214 | — |
| Winfield Healthcare Center | Winfield | Kansas | 67156 | — |
| Norton Cancer Institute-Downtown | Louisville | Kentucky | 40202 | — |
| Norton Cancer Institute-Norton Healthcare Pavilion | Louisville | Kentucky | 40202 | — |
| University of Louisville-James Graham Brown Cancer Center | Louisville | Kentucky | 40202 | — |
| Baptist Health Louisville; Consultants in Blood Disorders and Cancer | Louisville | Kentucky | 40207 | — |
| Norton Cancer Institute-St Matthews | Louisville | Kentucky | 40207 | — |
| Norton Cancer Institute-Brownsboro | Louisville | Kentucky | 40241 | — |
| Ochsner Medical Center-Kenner | Kenner | Louisiana | 70065 | — |
| West Jefferson Medical Center Cancer Center | Marrero | Louisiana | 70072 | — |
| University Medical Center New Orleans | New Orleans | Louisiana | 70112 | — |
| Ochsner Medical Center | New Orleans | Louisiana | 70121 | — |
| Greater Baltimore Medical Center | Baltimore | Maryland | 21204 | — |
| Medstar Union Memorial Hospital | Baltimore | Maryland | 21218 | — |
| Harry and Jeanette Weinberg Cancer Center at Franklin Square | Baltimore | Maryland | 21237 | — |
| Maryland Oncology Hematology | Bethesda | Maryland | 20817 | — |
| Maryland Oncology - Hematology Brandywine | Brandywine | Maryland | 20613 | — |
| Maryland Oncology - Hematology PA | Columbia | Maryland | 21044 | — |
| Maryland Oncology - Hematology Frederick | Frederick | Maryland | 21702 | — |
| Meritus Center for Clinical Research | Hagerstown | Maryland | 21742 | — |
| Maryland Oncology - Hematology PA | Lanham | Maryland | 20706 | — |
| Maryland Oncology Hematology | Rockville | Maryland | 20850 | — |
| Capital Hematology Oncology Associates | Silver Spring | Maryland | 20904 | — |
| Holy Cross Hospital | Silver Spring | Maryland | 20910 | — |
| University of Maryland, St. Joseph Medical Center | Towson | Maryland | 21204 | — |
| Maryland Oncology Hematology | Wheaton | Maryland | 20902 | — |
| Berkshire Hematology Oncology Services at Berkshire Medical Center Cancer and Infusion Center | Pittsfield | Massachusetts | 01201 | — |
| Henry Ford Cancer Institute Brownstown | Brownstown | Michigan | 48183 | — |
| Henry Ford Cancer Institute Macomb Hospital | Clinton Township | Michigan | 48038 | — |
| Henry Ford Medical Center Fairlane | Dearborn | Michigan | 48126 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Michigan State University | East Lansing | Michigan | 48823 | — |
| Henry Ford Allegiance Health | Jackson | Michigan | 49201 | — |
| Michigan State University-Breslin Cancer Center | Lansing | Michigan | 48910 | — |
| Henry Ford Medical Center Columbus | Novi | Michigan | 48377 | — |
| Henry Ford Hospital W Bloomfield | West Bloomfield | Michigan | 48322 | — |
| Henry Ford Cancer Institute Wyandotte Hospital | Wyandotte | Michigan | 48192 | — |
| University of Missouri-Ellis Fischel Cancer Center | Columbia | Missouri | 65212 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| MD Anderson Cancer Center at Cooper | Voorhees Township | New Jersey | 08043 | — |
| New York Oncology Hematology PC | Albany | New York | 12206 | — |
| Broome Oncolgy | Binghamton | New York | 13905 | — |
| Broome Oncology | Johnson City | New York | 13790 | — |
| Health Quest Medical Practice | Poughkeepsie | New York | 12601 | — |
| Vassar Brothers Medical Center | Poughkeepsie | New York | 12601 | — |
| RHOA of Cary | Cary | North Carolina | 27518 | — |
| Waverly Hematology Oncology | Cary | North Carolina | 27518 | — |
| Carolinas Medical Center-Levine Cancer Insitute | Charlotte | North Carolina | 28204 | — |
| Levine Cancer Center Institute Pineville | Charlotte | North Carolina | 28210 | — |
| RHOA of Garner | Garner | North Carolina | 27529 | — |
| UNC Regional Physicians Hematology and Oncolgoy | High Point | North Carolina | 27262 | — |
| FirstHealth of the Carolinas FirstHealth Outpatient Cancer Center | Pinehurst | North Carolina | 28374 | — |
| Rex Cancer Center | Raleigh | North Carolina | 27607 | — |
| RHOA of Blue Ridge | Raleigh | North Carolina | 27607 | — |
| RCC of Wakefield | Raleigh | North Carolina | 27614 | — |
| Nash UNC Health Care - Danny Talbott Cancer Center | Rocky Mount | North Carolina | 28704 | — |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | — |
| Aultman Alliance Cancer Center | Alliance | Ohio | 44601 | — |
| Aultman Hospital | Canton | Ohio | 44710 | — |
| Aultman Medical Group Hematology and Oncology | Canton | Ohio | 44710 | — |
| The Ohio State University Wexner Medical Center-Investigational Drug Service Oncology | Columbus | Ohio | 43210 | — |
| The Stephanie Speilman Comprehensive Breast Center | Columbus | Ohio | 43212 | — |
| Willamette Valley Cancer Institute and Research Center | Eugene | Oregon | 97401 | — |
| Kaiser Permanente Northwest-Oncology/Hematology | Portland | Oregon | 97227 | — |
| Northwest Cancer Specialists | Tigard | Oregon | 97223 | — |
| UPMC Hillman Cancer Center-Beaver | Beaver | Pennsylvania | 15009 | — |
| UPMC Hillman Cancer Center - Passavant North | Cranberry Township | Pennsylvania | 16066 | — |
| Ephrata Cancer Center | Ephrata | Pennsylvania | 17522 | — |
| Allegheny Cancer Institute St. Vincent | Erie | Pennsylvania | 16505 | — |
| St. Vincent Hospital | Erie | Pennsylvania | 16544 | — |
| UPMC Cancer Center Horizon | Farrell | Pennsylvania | 16121 | — |
| Wellspan Medical Oncology | Gettysburg | Pennsylvania | 17325 | — |
| UPMC Hillman Cancer Center- Mountain View | Greensburg | Pennsylvania | 15601 | — |
| UPMC Cancer Center Greenville | Greenville | Pennsylvania | 16125 | — |
| AHN Cancer Institute at Jefferson | Jefferson Hills | Pennsylvania | 15025 | — |
| Seechler Family Cancer Center | Lebanon | Pennsylvania | 17042 | — |
| Forbes Regional Hospital | Monroeville | Pennsylvania | 15146 | — |
| UPMC Hillman Cancer Center UPMC East-Monroeville | Monroeville | Pennsylvania | 15146 | — |
| UPMC Hillman Cancer Center Norwin | N. Huntingdon | Pennsylvania | 15642 | — |
| UPMC Hillman Cancer Center New Castle | New Castle | Pennsylvania | 16105 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| WPAON at AGH | Pittsburgh | Pennsylvania | 15212 | — |
| WPAON at WPH | Pittsburgh | Pennsylvania | 15212 | — |
| Magee-Women's Hospital of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | — |
| Western Pennsylvania Hospital | Pittsburgh | Pennsylvania | 15224 | — |
| UPCI Investigational Drug Services | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC Hillman Cancer Center @ Passavant - HOA | Pittsburgh | Pennsylvania | 15237 | — |
| UPMC Hillman Cancer Center @ Passavant - OHA | Pittsburgh | Pennsylvania | 15237 | — |
| UPMC Hillman Cancer Center-Upper Saint Clair | Pittsburgh | Pennsylvania | 15243 | — |
| UPMC Cancer Center Northwest | Seneca | Pennsylvania | 16346 | — |
| UPMC Hillman Cancer Center - Uniontown | Uniontown | Pennsylvania | 15401 | — |
| UPMC Hillman Cancer Center-Washington | Washington | Pennsylvania | 15301 | — |
| Wexford Health & Wellness Pavilion | Wexford | Pennsylvania | 15090 | — |
| Cancer Care Associates of York | York | Pennsylvania | 17403 | — |
| Wellspan Health-York Cancer Center Oncology Research | York | Pennsylvania | 17403 | — |
| Women's and Infants Hospital | Providence | Rhode Island | 02905 | — |
| Gibbs Cancer Center and Research Institute - Pelham | Greer | South Carolina | 29651 | — |
| Spartanburg Medical Center | Spartanburg | South Carolina | 29303 | — |
| Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | 57104 | — |
| Avera Cancer Institute-Sioux Falls | Sioux Falls | South Dakota | 57105 | — |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | — |
| Wellmont Cancer Institute | Johnson City | Tennessee | 37601 | — |
| Wellmont Cancer Institute | Kingsport | Tennessee | 37660 | — |
| Dell Seton Medical Center at the University of Texas-Seton Infusion Center | Austin | Texas | 72701 | — |
| Texas Oncology Bedford | Bedford | Texas | 76022 | — |
| Texas Oncology Carrollton | Carrollton | Texas | 75010 | — |
| Texas Oncology - Methodist Dallas Cancer Center | Dallas | Texas | 75203 | — |
| Texas Oncology - Medical City Dallas | Dallas | Texas | 75230 | — |
| Texas Oncology Dallas Presbyterian Hospital | Dallas | Texas | 75231 | — |
| Texas Oncology Denton | Denton | Texas | 76201 | — |
| Texas Oncology Flower Mound | Flower Mound | Texas | 75028 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Houston Methodist Cancer Center | Houston | Texas | 77030 | — |
| Harris Health System-Smith Clinic | Houston | Texas | 77054 | — |
| Texas Oncology - McAllen South Second | McAllen | Texas | 78503 | — |
| Texas Oncology Midland Allison Cancer Center | Midland | Texas | 79701 | — |
| Texas Oncology Plano | Plano | Texas | 75075 | — |
| Texas Oncology - The Woodlands | The Woodlands | Texas | 77380 | — |
| Wellmont Medical Associates-Oncology and Hematology | Bristol | Virginia | 24201 | — |
| Virginia Cancer Care Specialist | Leesburg | Virginia | 20176 | — |
| Centra Lynchburg Hematology Oncology | Lynchburg | Virginia | 24501 | — |
| Bon Secours Richmond Community Hospital Medical Oncology Associates at Memorial Regional Medical Center | Mechanicsville | Virginia | 23116 | — |
| Bon Secours St Francis Medical Center | Midlothian | Virginia | 23114 | — |
| Southwest Virginia Regional Cancer Center | Norton | Virginia | 24273 | — |
| Bon Secours Richmond Community Hospital Oncology Associates at St. Mary's Hospital | Richmond | Virginia | 23226 | — |
| MRCC Auburn | Auburn | Washington | 98001 | — |
| MRCC Gig Harbor | Gig Harbor | Washington | 98335 | — |
| MRCC Puyallup | Puyallup | Washington | 98372 | — |
| MultiCare Health System | Tacoma | Washington | 98405 | — |
| MultiCare Institute for Research & Innovation | Tacoma | Washington | 98405 | — |
| CAMC Health Education and Research Institute | Charleston | West Virginia | 25304 | — |
| West Virginia University | Morgantown | West Virginia | 26506 | — |
| Aurora Cancer Care-Southern Lakes | Burlington | Wisconsin | 53105 | — |
| Aurora Health Center Fond du Lac | Fond du Lac | Wisconsin | 54937 | — |
| Aurora Cancer Care-Germantown Health Center | Germantown | Wisconsin | 53022 | — |
| Aurora Cancer Care-Grafton | Grafton | Wisconsin | 53024 | — |
| Aurora BayCare Medical Center | Green Bay | Wisconsin | 54311 | — |
| Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | 53142 | — |
| Aurora Cancer Care | Milwaukee | Wisconsin | 53209 | — |
| Aurora Cancer Care-Milwaukee South | Milwaukee | Wisconsin | 53215 | — |
| Aurora St. Lukes Medical Center-Pharmacy Only | Milwaukee | Wisconsin | 53215 | — |
| Aurora West Allis Medical Center | Milwaukee | Wisconsin | 53227 | — |
| Aurora Sinai Medical Center | Milwaukee | Wisconsin | 53233 | — |
| Vince Lombardi Cancer Clinic Oshkosh | Oshkosh | Wisconsin | 54904 | — |
| Aurora Cancer Care-Racine | Racine | Wisconsin | 53406 | — |
| Vince Lombardi Cancer Clinic Sheboygan | Sheboygan | Wisconsin | 53081 | — |
| Aurora Medical Center in Summit | Summit | Wisconsin | 53066 | — |
| Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | 54241 | — |
| Aurora Cancer Care | Wauwatosa | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03281954, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 8, 2024 · Synced Oct 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03281954 live on ClinicalTrials.gov.