A Study of the Effect of IW-1701 (Olinciguat), a Stimulator of Soluble Guanylate Cyclase (sGC), on Patients With Sickle Cell Disease (SCD)
Public ClinicalTrials.gov record NCT03285178. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Placebo-controlled, Phase 2 Study to Evaluate the Safety and Pharmacodynamics of Once-daily Oral IW-1701 in Patients With Stable Sickle Cell Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of the 1701-202 STRONG SCD study is to evaluate the safety and tolerability of different dose levels of IW-1701 compared with placebo when administered daily for approximately 12 weeks to patients with stable SCD. Exploratory objectives include evaluation of pharmacokinetic (PK) as well as evaluation of the effect of IW-1701 on symptoms of SCD, health-related quality of life, and biomarkers of pharmacodynamic (PD) activity.
Study identification
- NCT ID
- NCT03285178
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 88 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 16 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 22, 2017 (Actual)
- Primary completion
- Jul 22, 2020 (Actual)
- Completion
- Jul 22, 2020 (Actual)
- Last update posted
- Jul 21, 2023
2017 – 2020
United States locations
- U.S. sites
- 30
- U.S. states
- 18
- U.S. cities
- 26
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Children's Hospital of Orange County | Orange | California | 92868 | — |
| MedStar Health Research Institute, MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Howard University Center for Sickle Cell Disease | Washington D.C. | District of Columbia | 20060 | — |
| Innovative Medical Research of South Florida, Inc. | Aventura | Florida | 33180 | — |
| Century Clinical Research, Inc. | Fort Lauderdale | Florida | 32117 | — |
| Foundation for Sickle Cell Disease Research | Hollywood | Florida | 33021 | — |
| Omega Research Maitland, LLC | Orlando | Florida | 32810 | — |
| Grady Memorial Hospital | Atlanta | Georgia | 30303 | — |
| Atlanta Center for Medical Research | Atlanta | Georgia | 30331 | — |
| University of Illinois at Chicago | Chicago | Illinois | 60612 | — |
| Healthcare Research Network II, LLC | Flossmoor | Illinois | 60422 | — |
| Clinical Trials of SWLA, LLC | Lake Charles | Louisiana | 70601 | — |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| Johns Hopkins School of Medicine Children's Center | Baltimore | Maryland | 21205 | — |
| Boston Children's Hospital | Boston | Massachusetts | 02115 | — |
| Children's Hospital of Michigan-Detroit | Detroit | Michigan | 33021 | — |
| Healthcare Research Network | Hazelwood | Missouri | 63042 | — |
| Hackensack University Medical Center, Pediatric Hematology and Oncology | Hackensack | New Jersey | 07601 | — |
| Jacobi Medical Center | The Bronx | New York | 10461 | — |
| New York Medical College | Valhalla | New York | 10595 | — |
| East Carolina University - Leo W. Jenkins Cancer Center | Greenville | North Carolina | 27834 | — |
| East Carolina University Brody School of Medicine, Department of Pediatrics, Division of Pediatric Hematology | Greenville | North Carolina | 27834 | — |
| Lynn Institute of Tulsa | Tulsa | Oklahoma | 74105 | — |
| The Clinical Trial Center LLC | Jenkintown | Pennsylvania | 19046 | — |
| University of Pittsburgh Medical Center Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| Accurate Clinical Research | Baytown | Texas | 77521 | — |
| "UT Health Clinical Research Unit Center for Clinical and Translational Sciences | Houston | Texas | 77030 | — |
| Mays Cancer Center UT Health San Antonio | San Antonio | Texas | 78229 | — |
| Virginia Commonwealth University - Clinical Research Unit | Richmond | Virginia | 23298 | — |
| Blood Center of Wisconsin (BCW) | Wauwatosa | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03285178, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 21, 2023 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03285178 live on ClinicalTrials.gov.