TRANSFORM-HF: ToRsemide compArisoN With furoSemide FORManagement of Heart Failure
Public ClinicalTrials.gov record NCT03296813. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
TRANSFORM-HF is a large-scale, pragmatic, randomized, unblinded clinical effectiveness study comparing torsemide versus furosemide as treatment for heart failure. Approximately 6,000 patients with heart failure will be enrolled. The primary objective of the TRANSFORM-HF study is to compare the treatment strategy of torsemide versus furosemide on clinical outcomes over 12 months in patients with heart failure who are hospitalized.
Study identification
- NCT ID
- NCT03296813
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,973 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 11, 2018 (Actual)
- Primary completion
- Jul 29, 2022 (Actual)
- Completion
- Jul 29, 2022 (Actual)
- Last update posted
- Oct 16, 2025
2018 – 2022
United States locations
- U.S. sites
- 60
- U.S. states
- 27
- U.S. cities
- 54
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Russel Medical Center | Alexander City | Alabama | 35010 | — |
| The Heart Center, PC | Huntsville | Alabama | 35801 | — |
| University of Arizona | Tucson | Arizona | 85724 | — |
| V.A. Greater Los Angeles Healthcare System | Los Angeles | California | 90073 | — |
| Kaiser Permanente Medical Center | San Francisco | California | 94115 | — |
| Saint Francis Hospital and Medical Center | Hartford | Connecticut | 06105 | — |
| Yale | New Haven | Connecticut | 06511 | — |
| West Haven VA Medical Center | West Haven | Connecticut | 06516 | — |
| Holy Cross Hospital | Fort Lauderdale | Florida | 33308 | — |
| University of Florida - Gainesville | Gainesville | Florida | 32610 | — |
| Emory Health Care | Atlanta | Georgia | 30322 | — |
| Augusta University | Augusta | Georgia | 30912 | — |
| Queens Medical Center | Honolulu | Hawaii | 96813 | — |
| Fox Valley Clinical Research Center | Aurora | Illinois | 60506 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61606 | — |
| Indiana University Health Bloomington Hospital | Bloomington | Indiana | 47402 | — |
| Indiana University Medical Center | Indianapolis | Indiana | 46202 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| University Medical Center | New Orleans | Louisiana | 70112 | — |
| Oschner Clinic | New Orleans | Louisiana | 70121 | — |
| VA Medical Center/University of Maryland | Baltimore | Maryland | 21201 | — |
| Shady Grove Medical Center | Rockville | Maryland | 20850 | — |
| University of Michigan Medical Center | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Saint Joseph Mercy Health System / Michigan Heart | Ypsilanti | Michigan | 48197 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 29216 | — |
| Lester E. Cox Health Systems | Springfield | Missouri | 65807 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| AtlantiCare Regional Medical Center | Pomona | New Jersey | 08240 | — |
| Presbyterian/Brooklyn Methodist Hospital | Brooklyn | New York | 11215 | — |
| North Shore University Hospital | Manhasset | New York | 11030 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| Mount Sinai | New York | New York | 10029-6574 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Stony Brook University Hospital | Stony Brook | New York | 11794 | — |
| Montefore Medical Center - Albert Einstein University Hospital | The Bronx | New York | 10461 | — |
| University of North Carolina School of Medicine | Chapel Hill | North Carolina | 27514 | — |
| Duke (Duke Heart Center) | Durham | North Carolina | 27710 | — |
| Novant Health Matthews Medical Center | Matthews | North Carolina | 28240 | — |
| New Hanover Regional Medical Center | Wilmington | North Carolina | 28401 | — |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Abington Memorial Hospital | Abington | Pennsylvania | 19001 | — |
| Good Samaritan Hospital | Ephrata | Pennsylvania | 17522 | — |
| Drexel University College of Medicine | Philadelphia | Pennsylvania | 19102 | — |
| Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Main Line Health System | Wynnewood | Pennsylvania | 19096 | — |
| Greenville Hospital System University Medical Center | Greenville | South Carolina | 29605 | — |
| Black Hills Cardiovascular Research | Rapid City | South Dakota | 57701 | — |
| Baylor University Medical Center | Dallas | Texas | 75246 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| University of Utah Hospitals and Clinics | Salt Lake City | Utah | 84132 | — |
| Inova Health Care Services | Falls Church | Virginia | 22042 | — |
| Sentara Norfolk General Hospital | Norfolk | Virginia | 23507 | — |
| Virginia Commonwealth University Health | Richmond | Virginia | 23298 | — |
| Froedtert Hospital | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03296813, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 16, 2025 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03296813 live on ClinicalTrials.gov.