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ClinicalTrials.gov record
Completed Phase 2 Interventional Results available

Testing the Addition of Radiation Therapy to Immunotherapy for Merkel Cell Carcinoma

ClinicalTrials.gov ID: NCT03304639

Public ClinicalTrials.gov record NCT03304639. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 29, 2026, 4:20 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Phase II Study of Anti-PD1 Antibody [MK-3475 (Pembrolizumab)] Alone Versus Anti-PD1 Antibody Plus Stereotactic Body Radiation Therapy in Advanced Merkel Cell Carcinoma

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This randomized phase II trial studies how well pembrolizumab with or without stereotactic body radiation therapy works in treating patients with Merkel cell cancer that has spread to other places in the body (advanced). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Stereotactic body radiation therapy uses special equipment to position a patient and deliver radiation to tumors with high precision. This method can kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Giving pembrolizumab with stereotactic body radiation therapy may work better in treating patients with Merkel cell cancer.

Study identification

NCT ID
NCT03304639
Recruitment status
Completed
Study type
Interventional
Phase
Phase 2
Enrollment
9 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 12, 2018 (Actual)
Primary completion
Jun 7, 2022 (Actual)
Completion
Feb 19, 2026 (Actual)
Last update posted
Aug 25, 2026

2018 – 2026

United States locations

U.S. sites
254
U.S. states
36
U.S. cities
175
Facility City State ZIP Site status
Anchorage Associates in Radiation Medicine Anchorage Alaska 98508 —
Alaska Breast Care and Surgery LLC Anchorage Alaska 99508 —
Alaska Oncology and Hematology LLC Anchorage Alaska 99508 —
Alaska Women's Cancer Care Anchorage Alaska 99508 —
Anchorage Oncology Centre Anchorage Alaska 99508 —
Katmai Oncology Group Anchorage Alaska 99508 —
Providence Alaska Medical Center Anchorage Alaska 99508 —
Banner University Medical Center - Tucson Tucson Arizona 85719 —
University of Arizona Cancer Center-North Campus Tucson Arizona 85719 —
Mercy Hospital Fort Smith Fort Smith Arkansas 72903 —
CHI Saint Vincent Cancer Center Hot Springs Hot Springs Arkansas 71913 —
PCR Oncology Arroyo Grande California 93420 —
Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California 91505 —
Penrose-Saint Francis Healthcare Colorado Springs Colorado 80907 —
Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado 80907 —
AdventHealth Porter Denver Colorado 80210 —
Saint Anthony Hospital Lakewood Colorado 80228 —
AdventHealth Littleton Littleton Colorado 80122 —
Longmont United Hospital Longmont Colorado 80501 —
AdventHealth Parker Parker Colorado 80138 —
Saint Mary Corwin Medical Center Pueblo Colorado 81004 —
Rocky Mountain Cancer Centers-Thornton Thornton Colorado 80260 —
Smilow Cancer Center/Yale-New Haven Hospital New Haven Connecticut 06510 —
Yale University New Haven Connecticut 06520 —
Mount Sinai Comprehensive Cancer Center at Aventura Aventura Florida 33180 —
Holy Cross Hospital Fort Lauderdale Florida 33308 —
Mount Sinai Medical Center Miami Beach Florida 33140 —
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah Georgia 31405 —
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706 —
Saint Luke's Cancer Institute - Boise Boise Idaho 83712 —
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605 —
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814 —
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619 —
Idaho Urologic Institute-Meridian Meridian Idaho 83642 —
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642 —
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687 —
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83687 —
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854 —
Kootenai Clinic Cancer Services - Sandpoint Sandpoint Idaho 83864 —
Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho 83301 —
Rush-Copley Medical Center Aurora Illinois 60504 —
Northwestern University Chicago Illinois 60611 —
Rush MD Anderson Cancer Center Chicago Illinois 60612 —
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637 —
Carle at The Riverfront Danville Illinois 61832 —
Carle Physician Group-Effingham Effingham Illinois 62401 —
Northwestern Medicine Lake Forest Hospital Lake Forest Illinois 60045 —
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938 —
SSM Health Good Samaritan Mount Vernon Illinois 62864 —
UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois 60451 —
University of Chicago Medicine-Orland Park Orland Park Illinois 60462 —
Carle Cancer Center Urbana Illinois 61801 —
The Carle Foundation Hospital Urbana Illinois 61801 —
Rush-Copley Healthcare Center Yorkville Illinois 60560 —
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis Indiana 46202 —
Sidney and Lois Eskenazi Hospital Indianapolis Indiana 46202 —
Mercy Cancer Center-West Lakes Clive Iowa 50325 —
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive Iowa 50325 —
Greater Regional Medical Center Creston Iowa 50801 —
Iowa Methodist Medical Center Des Moines Iowa 50309 —
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines Iowa 50309 —
Broadlawns Medical Center Des Moines Iowa 50314 —
Mercy Medical Center - Des Moines Des Moines Iowa 50314 —
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines Iowa 50314 —
Iowa Lutheran Hospital Des Moines Iowa 50316 —
Methodist West Hospital West Des Moines Iowa 50266-7700 —
Mercy Medical Center-West Lakes West Des Moines Iowa 50266 —
Central Care Cancer Center - Garden City Garden City Kansas 67846 —
Central Care Cancer Center - Great Bend Great Bend Kansas 67530 —
University of Kansas Cancer Center Kansas City Kansas 66160 —
Lawrence Memorial Hospital Lawrence Kansas 66044 —
Kansas Institute of Medicine Cancer and Blood Center Lenexa Kansas 66219 —
Minimally Invasive Surgery Hospital Lenexa Kansas 66219 —
Menorah Medical Center Overland Park Kansas 66209 —
University of Kansas Cancer Center-Overland Park Overland Park Kansas 66210 —
Saint Luke's South Hospital Overland Park Kansas 66213 —
University of Kansas Hospital-Westwood Cancer Center Westwood Kansas 66205 —
Cancer Center of Kansas-Wichita Medical Arts Tower Wichita Kansas 67208 —
Ascension Via Christi Hospitals Wichita Wichita Kansas 67214 —
Cancer Center of Kansas - Wichita Wichita Kansas 67214 —
Saint Joseph Radiation Oncology Resource Center Lexington Kentucky 40504 —
Saint Joseph Hospital East Lexington Kentucky 40509 —
Jewish Hospital Louisville Kentucky 40202 —
UofL Health Medical Center Northeast Louisville Kentucky 40245 —
Ochsner Health Center-Summa Baton Rouge Louisiana 70809 —
Medical Center of Baton Rouge Baton Rouge Louisiana 70816 —
Ochsner High Grove Baton Rouge Louisiana 70836 —
Ochsner Medical Center Jefferson New Orleans Louisiana 70121 —
Bronson Battle Creek Battle Creek Michigan 49017 —
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids Michigan 49503 —
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital Grand Rapids Michigan 49503 —
Trinity Health Grand Rapids Hospital Grand Rapids Michigan 49503 —
Bronson Methodist Hospital Kalamazoo Michigan 49007 —
West Michigan Cancer Center Kalamazoo Michigan 49007 —
Beacon Kalamazoo Kalamazoo Michigan 49048 —
Trinity Health Muskegon Hospital Muskegon Michigan 49444 —
Corewell Health Lakeland Hospitals - Niles Hospital Niles Michigan 49120 —
Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan 49444 —
Corewell Health Reed City Hospital Reed City Michigan 49677 —
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph Michigan 49085 —
Corewell Health Lakeland Hospitals - Saint Joseph Hospital Saint Joseph Michigan 49085 —
Munson Medical Center Traverse City Michigan 49684 —
University of Michigan Health - West Wyoming Michigan 49519 —
Sanford Joe Lueken Cancer Center Bemidji Minnesota 56601 —
Fairview Ridges Hospital Burnsville Minnesota 55337 —
Mercy Hospital Coon Rapids Minnesota 55433 —
Fairview Southdale Hospital Edina Minnesota 55435 —
Unity Hospital Fridley Minnesota 55432 —
Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota 55369 —
Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota 55109 —
Saint John's Hospital - Healtheast Maplewood Minnesota 55109 —
Abbott-Northwestern Hospital Minneapolis Minnesota 55407 —
Hennepin County Medical Center Minneapolis Minnesota 55415 —
Health Partners Inc Minneapolis Minnesota 55454 —
Monticello Cancer Center Monticello Minnesota 55362 —
North Memorial Medical Health Center Robbinsdale Minnesota 55422 —
Mayo Clinic in Rochester Rochester Minnesota 55905 —
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416 —
Regions Hospital Saint Paul Minnesota 55101 —
United Hospital Saint Paul Minnesota 55102 —
Saint Francis Regional Medical Center Shakopee Minnesota 55379 —
Lakeview Hospital Stillwater Minnesota 55082 —
Ridgeview Medical Center Waconia Minnesota 55387 —
Rice Memorial Hospital Willmar Minnesota 56201 —
Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota 55125 —
Mercy Oncology and Hematology - Clayton-Clarkson Ballwin Missouri 63011 —
Central Care Cancer Center - Bolivar Bolivar Missouri 65613 —
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376 —
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141 —
Centerpoint Medical Center LLC Independence Missouri 64057 —
Freeman Health System Joplin Missouri 64804 —
Saint Luke's Hospital of Kansas City Kansas City Missouri 64111 —
Research Medical Center Kansas City Missouri 64132 —
Saint Luke's East - Lee's Summit Lee's Summit Missouri 64086 —
Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri 65401 —
Phelps Health Delbert Day Cancer Institute Rolla Missouri 65401 —
Heartland Regional Medical Center Saint Joseph Missouri 64506 —
Mercy Hospital Springfield Springfield Missouri 65804 —
CoxHealth South Hospital Springfield Missouri 65807 —
Washington University School of Medicine St Louis Missouri 63110 —
Mercy Hospital South St Louis Missouri 63128 —
Siteman Cancer Center-South County St Louis Missouri 63129 —
Mercy Hospital Saint Louis St Louis Missouri 63141 —
Community Hospital of Anaconda Anaconda Montana 59711 —
Billings Clinic Cancer Center Billings Montana 59101 —
Bozeman Health Deaconess Hospital Bozeman Montana 59715 —
Benefis Sletten Cancer Institute Great Falls Montana 59405 —
Great Falls Clinic Great Falls Montana 59405 —
Saint Peter's Community Hospital Helena Montana 59601 —
Logan Health Medical Center Kalispell Montana 59901 —
Community Medical Center Missoula Montana 59804 —
Nebraska Cancer Specialists/Oncology Hematology West PC Grand Island Nebraska 68803 —
CHI Health Good Samaritan Kearney Nebraska 68847 —
Alegent Health Immanuel Medical Center Omaha Nebraska 68122 —
Alegent Health Bergan Mercy Medical Center Omaha Nebraska 68124 —
Alegent Health Lakeside Hospital Omaha Nebraska 68130 —
Creighton University Medical Center Omaha Nebraska 68131 —
Comprehensive Cancer Centers of Nevada - Henderson Henderson Nevada 89052 —
Oncology Las Vegas - Henderson Henderson Nevada 89074 —
OptumCare Cancer Care at Charleston Las Vegas Nevada 89102 —
Radiation Oncology Centers of Nevada Central Las Vegas Nevada 89106 —
Radiation Oncology Centers of Nevada Southeast Las Vegas Nevada 89119 —
Comprehensive Cancer Centers of Nevada - Northwest Las Vegas Nevada 89128 —
OptumCare Cancer Care at MountainView Las Vegas Nevada 89128 —
Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas Nevada 89135 —
Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas Nevada 89144 —
Comprehensive Cancer Centers of Nevada Las Vegas Nevada 89148 —
Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada 89169 —
OptumCare Cancer Care at Fort Apache Las Vegas Nevada 89183 —
Renown Regional Medical Center Reno Nevada 89502 —
Saint Mary's Regional Medical Center Reno Nevada 89503 —
Radiation Oncology Associates Reno Nevada 89509 —
Hackensack University Medical Center Hackensack New Jersey 07601 —
Duke University Medical Center Durham North Carolina 27710 —
Sanford Bismarck Medical Center Bismarck North Dakota 58501 —
Sanford Broadway Medical Center Fargo North Dakota 58122 —
Sanford Roger Maris Cancer Center Fargo North Dakota 58122 —
Strecker Cancer Center-Belpre Belpre Ohio 45714 —
Adena Regional Medical Center Chillicothe Ohio 45601 —
Good Samaritan Hospital - Cincinnati Cincinnati Ohio 45220 —
Bethesda North Hospital Cincinnati Ohio 45242 —
MetroHealth Medical Center Cleveland Ohio 44109 —
Mount Carmel East Hospital Columbus Ohio 43213 —
Columbus Oncology and Hematology Associates Inc Columbus Ohio 43214 —
Riverside Methodist Hospital Columbus Ohio 43214 —
Grant Medical Center Columbus Ohio 43215 —
The Mark H Zangmeister Center Columbus Ohio 43219 —
Mount Carmel Health Center West Columbus Ohio 43222 —
Doctors Hospital Columbus Ohio 43228 —
Delaware Health Center-Grady Cancer Center Delaware Ohio 43015 —
Delaware Radiation Oncology Delaware Ohio 43015 —
Grady Memorial Hospital Delaware Ohio 43015 —
Dublin Methodist Hospital Dublin Ohio 43016 —
Fairfield Medical Center Lancaster Ohio 43130 —
OhioHealth Mansfield Hospital Mansfield Ohio 44903 —
Marietta Memorial Hospital Marietta Ohio 45750 —
OhioHealth Marion General Hospital Marion Ohio 43302 —
Knox Community Hospital Mount Vernon Ohio 43050 —
Licking Memorial Hospital Newark Ohio 43055 —
Newark Radiation Oncology Newark Ohio 43055 —
Southern Ohio Medical Center Portsmouth Ohio 45662 —
Saint Ann's Hospital Westerville Ohio 43081 —
Genesis Healthcare System Cancer Care Center Zanesville Ohio 43701 —
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 —
Mercy Hospital Oklahoma City Oklahoma City Oklahoma 73120 —
Saint Charles Health System Bend Oregon 97701 —
Clackamas Radiation Oncology Center Clackamas Oregon 97015 —
Bay Area Hospital Coos Bay Oregon 97420 —
Providence Newberg Medical Center Newberg Oregon 97132 —
Providence Portland Medical Center Portland Oregon 97213 —
Providence Saint Vincent Medical Center Portland Oregon 97225 —
Geisinger Medical Center Danville Pennsylvania 17822 —
Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania 17837 —
Lewistown Hospital Lewistown Pennsylvania 17044 —
University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania 19104 —
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania 18711 —
Medical University of South Carolina Charleston South Carolina 29425 —
Gibbs Cancer Center-Gaffney Gaffney South Carolina 29341 —
Gibbs Cancer Center-Pelham Greer South Carolina 29651 —
Spartanburg Medical Center Spartanburg South Carolina 29303 —
SMC Center for Hematology Oncology Union Union South Carolina 29379 —
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104 —
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134 —
Memorial Hospital Chattanooga Tennessee 37404 —
Saint Joseph Regional Cancer Center Bryan Texas 77802 —
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 —
Providence Regional Cancer System-Aberdeen Aberdeen Washington 98520 —
Overlake Medical Center Bellevue Washington 98004 —
PeaceHealth Saint Joseph Medical Center Bellingham Washington 98225 —
Highline Medical Center-Main Campus Burien Washington 98166 —
Providence Regional Cancer System-Centralia Centralia Washington 98531 —
Providence Regional Cancer Partnership Everett Washington 98201 —
Swedish Cancer Institute-Issaquah Issaquah Washington 98029 —
Kadlec Clinic Hematology and Oncology Kennewick Washington 99336 —
Providence Regional Cancer System-Lacey Lacey Washington 98503 —
PeaceHealth Saint John Medical Center Longview Washington 98632 —
Valley Medical Center Renton Washington 98055 —
Swedish Medical Center-Ballard Campus Seattle Washington 98107 —
Kaiser Permanente Washington Seattle Washington 98112 —
Swedish Medical Center-First Hill Seattle Washington 98122 —
PeaceHealth United General Medical Center Sedro-Woolley Washington 98284 —
Saint Michael Cancer Center Silverdale Washington 98383 —
Northwest Medical Specialties PLLC Tacoma Washington 98405 —
PeaceHealth Southwest Medical Center Vancouver Washington 98664 —
Providence Saint Mary Regional Cancer Center Walla Walla Washington 99362 —
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701 —
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449 —
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548 —
Cancer Center of Western Wisconsin New Richmond Wisconsin 54017 —
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868 —
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482 —
Marshfield Clinic-Wausau Center Wausau Wisconsin 54401 —
Marshfield Medical Center - Weston Weston Wisconsin 54476 —
Billings Clinic-Cody Cody Wyoming 82414 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT03304639, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 25, 2026 · Synced Oct 29, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT03304639 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →